Impact of Preinterventional Arterial Remodeling on In-Stent Neointimal Hyperplasia and In-Stent Restenosis After Coronary Stent Implantation : An Intravascular Ultrasound Study
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概要
- 論文の詳細を見る
Background Patterns of arterial remodeling during the course of plaque development have been shown to play an important role in both the progression of de novo atherosclerosis and in the restenotic process following coronary intervention. The aim of the present prospective study was to evaluate the effect of pre-interventional arterial remodeling on in-stent neointimal hyperplasia (NIH) and in-stent restenosis (ISR) after stenting. Methods and Results Pre-interventional arterial remodeling was assessed in 85 native coronary lesions by using intravascular ultrasound (IVUS). The remodeling index (RI) was 1.09±0.20 in the positive remodeling (PR)/intermediate remodeling (IR) group and 0.84±0.12 in the negative remodeling (NR) group. The plaque plus media cross sectional area (P&M CSA) at pre-intervention and NIH CSA at follow-up in the minimal lumen CSA were significantly larger in the PR/IR group (9.2±2.9mm^2 vs 6.2±1.8mm^2, 3.3±1.2mm^2 vs 1.5±0.9mm^2 ; p=0.001, p=0.001, respectively). On 3-dimensional analysis of IVUS images at follow-up, the lumen volume was significantly smaller in the PR/IR group than that in the NR group (62±15mm^3 vs 75±20mm^3 ; p=0.001), and neointima hyperplasia volume was significantly larger in the PR/IR group than that in the NR group (46±15mm^3 vs 26±10mm^3 ; p=0.001). A significant positive correlation was found between pre-interventional RI and follow-up NIH CSA (r=0.25, p=0.022). The incidence of ISR and repeat intervention was significantly higher in the PR/IR group (30.8% vs 18.2%, 28.8% vs 15.2% ; p=0.032, 0.035, respectively). Conclusion Measuring pre-interventional arterial remodeling patterns by IVUS may be helpful to stratify lesions at high-risk of ISR.
- 社団法人日本循環器学会の論文
- 2005-03-20
著者
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Ahn Young
The Heart Center Of Chonnam National University Hospital
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Kim Ju
The Heart Center Of Chonnam National University Hospital
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HONG Young
The Heart Center of Chonnam National University Hospital
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JEONG Myung
The Heart Center of Chonnam National University Hospital
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KIM Weon
The Heart Center of Kyunghee University Hospital
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KIM Kye
The Heart Center of Chonnam National University Hospital
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PARK Hyung
The Heart Center of Chonnam National University Hospital
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CHO Jeong
The Heart Center of Chonnam National University Hospital
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PARK Jong
The Heart Center of Chonnam National University Hospital
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KANG Jung
The Heart Center of Chonnam National University Hospital
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Lim Sang
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Lee Sang
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Hong Seo
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Kang Dong
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Yun Kyung
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Kim Kun
The Heart Center Of Chonnam National University Hospital
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Lee Yeon
The Heart Center Of Chonnam National University Hospital Chonnam National University Research Instit
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Hong Seo
The Heart Center Ofchonnam National University Hospital Chonnam National University Research Institu
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Lee Sang
The Heart Center Of Chonnam National University Hospital Chonnam National University Research Instit
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Hur Seung
Keimyung University
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Jeong Myung
Yonsei University Wonju Hospital
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Hur Seung
Heart Center of Chonnam National University Hospital
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Lim Sang
The Cardiovascular Center Of Korea University Anam Hospital
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Kim Yong
Cardiovascular Research Institute Chonnam National University
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Jeong Yun
Lab Of Stem Cell And Tumor Biology College Of Veterinary Medicine Seoul National University
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Kang Dong
The Heart Center Of Chonnam National University Hospital Chonnam National University Research Instit
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Lee Sang
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Hyun Dae
Department of Internal Medicine, Keimyung University Dongsan Medical Center
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Hur Seung
Department of Internal Medicine, Keimyung University Dongsan Medical Center
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Kim Kwon
Department of Internal Medicine, Keimyung University Dongsan Medical Center
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Lee Yun
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Jeong Myung
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Kim Weon
Heart Center Chonnam National University Hospital
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Choi Ji-yong
Division Of Cardiology Department Of Internal Medicine College Of Medicine Daegu Catholic University
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Hur Seung-ho
Department Of Cardiology Keimyung University Dongsan Medical Center
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Ahn Young
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Park Jong
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Kang Jung
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Kim Kwon
Department Of Internal Medicine Keimyung University Dongsan Medical Center
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Kim Kyehun
Heart Center Chonnam National University Hospital
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Hyun Dae
Department Of Internal Medicine Keimyung University Dongsan Medical Center
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