Effects of β-Radiation Using a Holmium-166 Coated Balloon on Neointimal Hyperplasia in a Porcine Coronary Stent Restenosis Model
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概要
- 論文の詳細を見る
Brachytherapy is a promising method of preventing and treating coronary stent restenosis. The present study was designed to observe the therapeutic effects of a radioactive balloon loaded with Holmium-166 (^<166>Ho) in a porcine coronary stent restenosis model. A radioisotope of ^<166>Ho was coated onto the balloon surface using polyurethane (20 Gy at 0.5mm depth). Stent overdilation injuries were induced in 2 coronary arteries in each pig (n=8). Four weeks after the injury, control balloon dilation was performed in one coronary artery (Group I) and radiation therapy using the ^<166>Ho coated balloon in the other coronary artery (Group II) in each pig. Follow-up coronary angiography and histopathologic assessment were performed at 4 weeks after the radiation therapy or the control balloon dilations. With regard to complete blood cell counts, liver function tests, lipid profiles and coagulation tests, there were no differences between the baseline and after radiation. On quantitative coronary angiographic analysis, reference and target artery diameter showed no differences between the 2 groups before, or 4 and 8 weeks after stenting. On histopathologic analysis of groups I and II, the injury score was 1.34±0.09 and 1.32±0.10, the area of internal elastic lamina was 4.99±0.17mm^2 and 4.82±0.20mm^2, and the luminal area was 3.20±0.10mm^2 and 3.45±0.14mm^2, respectively (p=NS). The neointimal area was 1.78±0.11 mm^2 in group I and 1.36±0.12mm^2 in group II (p=0.017), and the histopathologic area of stenosis was 35.1±1.6% in group I and 27.6±1.9% in group II (p=0.005). In conclusion, β-radiation of the stented porcine coronary artery using a radioactive ^<166>Ho coated balloon inhibited stent restenosis without any side effects. (Circ J 2003 ; 67 : 625-629)
- 社団法人日本循環器学会の論文
- 2003-06-20
著者
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Ahn Young
The Heart Center Of Chonnam National University Hospital
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Rhew Jae
Jeonju Presbyterian Medical Center
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Kim Ju
The Heart Center Of Chonnam National University Hospital
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Park Keun
The Heart Center Of Chonnam National University Hospital
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KIM Weon
The Heart Center of Kyunghee University Hospital
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CHO Jeong
The Heart Center of Chonnam National University Hospital
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Rhew Jay
The Heart Center,Chonnam National University Hospital and Chonnam National University Research Insti
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KIM Eun
Korean Hemophilia Foundation Clinic
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Choi Sun
Korea Atomic Energy Research Institute
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Kim Yong
Cardiovascular Research Institute Chonnam National University
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Song Chang
Department Of Obstetrics And Gynecology Chosun University College Of Medicine
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Kim Eun
Korea Cancer Center Hospital
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Bom Hee
Chonnam National University Hwasun Hospital
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Bom Hee-seung
Institute For Molecular Photonic Imaging Research Chonnam National University Hospital
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Kim Weon
Heart Center Chonnam National University Hospital
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Park Ok
The Heart Center Chonnam National University Hospital
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Ahn Young
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Rhew Jay
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Park Kyung
Korea Atomic Energy Research Institute
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Jeong Myung
The Research Institute of Medical Sciences, Chonnam National University
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Bom Hee
Department of Nuclear Medicine, Chonnam National University Hospital
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Park Jong
The Research Institute of Medical Sciences, Chonnam National University
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Cho Jeong
The Research Institute of Medical Sciences, Chonnam National University
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Kang Jung
The Research Institute of Medical Sciences, Chonnam National University
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Park Jong
Department Of Pathology Chonnam National University Medical School
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