Effect of Green Tea Consumption on Endothelial Function and Circulating Endothelial Progenitor Cells in Chronic Smokers
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概要
- 論文の詳細を見る
Background The present study was designed to investigate the effect and relationship of endothelial function and endothelial progenitor cells (EPCs) by green tea consumption in chronic smokers. The numbers of circulating EPCs have an inverse correlation with chronic smoking and endothelial dysfunction. Green tea catechin improved endothelial dysfunction in chronic smokers. Method and Results In 20 young healthy smokers, endothelial functions, defined by flow-mediated endothelium dependent vasodilation (FMD) of the brachial artery via ultrasound as well as the number of EPCs isolated from peripheral blood, were determined at baseline and at 2 weeks after green tea consumption (8g/day). Circulating EPCs were quantified by flow cytometry as CD45lowCD34+KDR2+cells and by acyl-low-density lipoprotein and fluorescein isotiocyanate-lectin double positive cells after culture for 7 days. Clinical characteristics and laboratory findings were not significantly different between the baseline and at 2 weeks after green tea intake. EPC levels were inversely correlated with the number of cigarettes smoked. Circulating EPCs by flow cytometry (78.6±72.6 vs 156.1±135.8/ml, p<0.001) and cultured EPCs (118.2±35.7 vs 169.31±58.3/10 field, p<0.001) increased rapidly at 2 weeks after green tea consumption. FMD was significantly improved after 2 weeks (7.2±2.8 vs 9.3±2.4, p<0.001). The FMD correlated with EPC counts (r=0.67, p=0.003) before treatment and after 2 weeks (r=0.60, p=0.013). Conclusions A short-term administration of green tea consumption induces a rapid improvement of EPC levels and FMD. Green tea consumption may be effective to prevent future cardiovascular events in chronic smokers.
- 社団法人日本循環器学会の論文
- 2006-07-20
著者
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Ahn Young
The Heart Center Of Chonnam National University Hospital
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LEE Min
Department of Internal Medicine, Chonnam National University Hospital
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MUROHARA Toyoaki
Department of Cardiology, Nagoya University Graduate School of Medicine
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Kondo Takaaki
Department Of Cardiology Nagoya University Graduate School Of Medicine
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JEONG Myung
The Heart Center of Chonnam National University Hospital
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KIM Weon
The Heart Center of Kyunghee University Hospital
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CHO Jeong
The Heart Center of Chonnam National University Hospital
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KANG Jung
The Heart Center of Chonnam National University Hospital
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Cheng Xianwu
Department of Cardiology, Nagoya University Graduate School of Medicine
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Takemiya Kiyoko
Department of Internal Medicine Division of Cardio-Vascular Medicine
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Kondo Takahisa
Department of Cardiology, Nagoya University School of Medicine
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Kondo Takaaki
Department Of Internal Medicine Division Of Cardio-vascular Medicine
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Cheng Xianwu
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Kondo Takahisa
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Jeong Myung
Yonsei University Wonju Hospital
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Murohara Toyoaki
Department Of Cardiology Nagoya University Graduate School Of Medicaine
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Cho Sook
Heart Center of Chonnam National University Hospital
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Yun Ji
The Heart Center Department Of Chonnam National University Hospital
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Kim Yong
Cardiovascular Research Institute Chonnam National University
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Cho Suk
The Heart Research Center Of Chonnam National University Hospital
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Jeong Myung
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Chae Hong
Department of Occupational Environment Medicine, Chonnam National University Hospital
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Chae Hong
Department Of Occupational Environment Medicine Chonnam National University Hospital
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Takagi Kenzo
Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un
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CHO Sook
The Heart Research Center of Chonnam National University Hospital
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Kim Weon
Heart Center Chonnam National University Hospital
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Kawaguchi Takeshi
Kyoto University Center For Student Health
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Lee Min
Department Of Pathology Chonnam National University Hospital
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Cho Suk
The Heart Center Department Of Chonnam National University Hospital
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Choi Ji-yong
Division Of Cardiology Department Of Internal Medicine College Of Medicine Daegu Catholic University
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Ahn Young
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Kang Jung
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Lee Min
Department Of Aeronautics And Astronautics Kyushu University
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Cho Jungsun
Heart Center Chonnam National University Hospital
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Kondo Takaaki
Department Of Medical Technology Nagoya University School Of Health Science
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Murohara Toyoaki
Department Of Cardiology Nagoya Graduate School Of Medicine
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Matsuda Tadashi
The Department Of Urology Kansai Medical University
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Kosaka Takayuki
Department Of Thoracic Surgery Aichi Cancer Center Research Institute
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Murohara Toyoaki
Department Of Internal Medicine School Of Dentistry Aichi-gakuin University
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Jeong Myung
Department Of Cardiovascular Medicine Chonnam National University Medical School
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Kondo Takahisa
Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of Medicine
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