Effect of Vessel Size on Lipid Content of Coronary Plaques Assessed by Integrated Backscatter Intravascular Ultrasound
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概要
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Background: Tissue characterization of coronary plaques is feasible using integrated backscatter intravascular ultrasound (IB-IVUS), and higher lipid content has been found in the target lesions of acute coronary syndrome (ACS). The present study was performed to identify clinical and IVUS parameters that correlate with plaque composition assessed by IB-IVUS. Methods and Results: A total of 109 patients (age 60.0±9.7 years) were evaluated with IVUS and IB-IVUS prior to percutaneous coronary intervention. Patients with ACS had a larger vessel size and higher plaque burden in the target lesion than those with stable angina. Relative lipid content of the target lesion by IB-IVUS was also higher in ACS (43.6%±12.0% vs 29.9%±14.2%; P<0.001). The remodeling index (r=0.403, P<0.001), plaque burden (%) (r=0.495, P<0.001), and vessel size (r=0.572, P<0.001) significantly correlated with lipid content. In the multiple regression analysis, vessel size was the most important independent predictor of lipid content followed by presence of ACS and the remodeling index. Conclusions: ACS, positive remodeling, and larger plaque burden were associated with higher lipid content of coronary plaque. However, the lipid content on IB-IVUS was also significantly affected by vessel size. Therefore, qualitative, morphologic assessment of coronary plaque rather than simple quantitative analysis of tissue components seems to be more appropriate for the identification of vulnerable plaque using IB-IVUS.
- 2010-03-25
著者
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Ahn Young
The Heart Center Of Chonnam National University Hospital
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HONG Myeong-Ki
Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine
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KIM Jung-Sun
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine
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KO Young-Guk
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine
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CHOI Donghoon
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine
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JANG Yangsoo
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine
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Kim Ju
The Heart Center Of Chonnam National University Hospital
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Choi Donghoong
Division Of Cardiology Severance Cardiovascular Hospital Yonsei University College Of Medicine
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Hong Myeong-ki
Division Of Cardiology Severance Cardiovascular Hospital Yonsei University College Of Medicine
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Jang Yangsoo
Division Of Cardiology Severance Cardiovascular Hospital Yonsei University College Of Medicine
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Kim Jung-sun
Division Of Cardiology Severance Cardiovascular Hospital Yonsei University College Of Medicine
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Kim Jung-sun
Division Of Cardiology Department Of Laboratory Medicine Yonsei University College Of Medicine
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Ko Young-guk
Division Of Cardiology Severance Cardiovascular Hospital Yonsei University College Of Medicine
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JEONG Myung
The Heart Center of Chonnam National University Hospital
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SON Jung-Woo
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine
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PARK Sang
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine
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Park Sungha
Cardiology Division Department Of Internal Medicine Yonsei University College Of Medicine
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Park Sungha
Division Of Cardiology Severance Cardiovascular Hospital Yonsei University College Of Medicine
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Jang Yang
Yonsei University
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Jeong Myung
Yonsei University Wonju Hospital
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Yoon Jung
Heart Center of Chonnam National University Hospital
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Kim Yong
Cardiovascular Research Institute Chonnam National University
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Son Jung-woo
Division Of Cardiology Severance Cardiovascular Hospital Yonsei University College Of Medicine
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Ahn Youngkeun
Department Of Cardiovascular Medicine Chonnam National University Medical School
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KIM Jong-Youn
The first two authors equally contributed to this study
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Ahn Youngkeun
Heart Center Chonnam National University Hospital
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Jeong Myungho
Heart Center Chonnam National University Hospital
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Kim Yun-hyeon
Department Of Radiology Chonnam National University Hospital The Research Institute Of Medical Scien
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Kim Young
Department Of Radiology Chonnam National University Hospital The Research Institute Of Medical Scien
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Kim Yong
Department Of Radiology Chonnam National University Hospital The Research Institute Of Medical Scien
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Jeong Myung
Department Of Cardiovascular Medicine Chonnam National University Medical School
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Jang Yang
Wonju Christian Hospital
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