Myocardial Protective Effects of Nicorandil During Percutaneous Coronary Intervention in Patients With Unstable Angina
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概要
- 論文の詳細を見る
Background The purpose of the study was to prospectively evaluate the protective effect of nicorandil during percutaneous coronary intervention (PCI) in patients with unstable angina (UAP). Methods and Results Two hundred patients (61±10 year-old, male 143) diagnosed with UAP at an emergency medical center were randomly assigned to 2 groups : intravenous isosorbide dinitrate, Group I (n=100), or intravenous nicorandil, Group II (n=100). PCI was performed 12-48h after infusion of each agent. Serum concentrations of creatine kinase-MB (CK-MB), cardiac troponin T (cTnT), and I (cTnI) were measured before and 6, 12, 24h after PCI. Patients with non-coronary chest pain, requiring emergency coronary angiogram, temporary pacemaker or glycoprotein IIb/IIIa receptor blocker were excluded. PCI was successfully performed in 96 patients (Group I=54, 61.7±8.2 years, 32 males ; Group II=42, 60.4±11.7 years, 27males). No significant differences in clinical or coronary angiographic characteristics were observed between the 2 groups. The concentration of CK-MB was elevated in 9 patients (17%) of Group I and 6 (14%) of Group II, cTnT in 16 (30%), 6 (14%) and cTnI in 25 (46%), 9 (21%) after PCI. Elevation of any troponin was less frequent in Group II [28/54 (52%) vs 10/42 (24%) patients, p=0.01]. Major adverse coronary events during the 6-month clinical follow-up occurred in 9 (17%) of Group I and 5 patients of Group II (12%, p=NS). Follow-up echocardiography revealed lower left ventricular ejection fraction in Group I than in Group II (65.4±7.2% vs 71.0±6.7%, p=0.03). Conclusion Nicorandil has a myocardial protective effect during PCI in patients with UAP.
- 社団法人日本循環器学会の論文
- 2005-02-20
著者
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Ahn Young
The Heart Center Of Chonnam National University Hospital
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Kim Ju
The Heart Center Of Chonnam National University Hospital
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HONG Young
The Heart Center of Chonnam National University Hospital
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JEONG Myung
The Heart Center of Chonnam National University Hospital
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KIM Weon
The Heart Center of Kyunghee University Hospital
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KIM Kye
The Heart Center of Chonnam National University Hospital
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PARK Hyung
The Heart Center of Chonnam National University Hospital
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CHO Jeong
The Heart Center of Chonnam National University Hospital
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PARK Jong
The Heart Center of Chonnam National University Hospital
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KANG Jung
The Heart Center of Chonnam National University Hospital
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Lim Sang
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Lee Sang
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Hong Seo
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Kang Dong
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Yun Kyung
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Kim Kun
The Heart Center Of Chonnam National University Hospital
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Lee Yeon
The Heart Center Of Chonnam National University Hospital Chonnam National University Research Instit
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Hong Seo
The Heart Center Ofchonnam National University Hospital Chonnam National University Research Institu
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Lee Sang
The Heart Center Of Chonnam National University Hospital Chonnam National University Research Instit
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Lim Sang
The Cardiovascular Center Of Korea University Anam Hospital
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Kim Yong
Cardiovascular Research Institute Chonnam National University
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Jeong Yun
Lab Of Stem Cell And Tumor Biology College Of Veterinary Medicine Seoul National University
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Kang Dong
The Heart Center Ofchonnam National University Hospital Chonnam National University Research Institu
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Kang Dong
The Heart Center Of Chonnam National University Hospital Chonnam National University Research Instit
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Lee Sang
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Lee Yun
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Insti
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Jeong Myung
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Kim Weon
Heart Center Chonnam National University Hospital
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Choi Ji-yong
Division Of Cardiology Department Of Internal Medicine College Of Medicine Daegu Catholic University
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Ahn Young
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Park Jong
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Kang Jung
The Heart Center Chonnam National University Hospital The Research Institute Of Medical Sciences Cho
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Kim Kyehun
Heart Center Chonnam National University Hospital
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