Randomized Comparison of Cilostazol vs Clopidogrel After Drug-Eluting Stenting in Diabetic Patients : CIilostazol for Diabetic Patients in Drug-Eluting Stent (CIDES) Trial

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概要

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• Background Previous studies have shown that cilostazol may not only prevent stent thrombosis, but may also have positive effect in the prevention of restenosis. However, the effect of cilostazol on restenosis after successful deployment of drug-eluting stent (DES) in patients with diabetes mellitus has not been evaluated. Methods and Results A total of 280 patients at 8 clinical sites were randomized. The patients (61.7±9.9 years old, 163 males) who underwent successful stenting were randomized to aspirin and cilostazol (group I, n=141, 61.2±9.6 years old) vs aspirin and clopidogrel (group II, n=139, 62.0±10.0 years old) after 1 month of aspirin, cilostazol, and clopidogrel combination treatment. There were no significant differences in baseline characteristics of the groups. The type of DES implanted did not differ between the groups. There were no differences in angiographic and procedural characteristics of the groups. Major adverse cardiac events, including acute and subacute stent thrombosis within 1 month, did not occur in either group. Cases of angiographic late stent thrombosis were 1 (0.9%) in group I and 1 (0.8%) in group II. Follow-up coronary angiography was performed in 237 patients (84.6%). Mean follow-up duration was 7.1 months. The rate of angiographic restenosis (stent plus 5-mm borders) was 9 (8.0%) in group I and 20 (16.1 %) in group II, p=0.041). The minimal luminal diameter at follow-up period in group I was 2.55±0.63mm compared with 2.41±0.83mm in group II (p=NS). Conclusions Combination therapy with aspirin and cilostazol for the prevention of stent restenosis is comparable or superior to that of aspirin and clopidogrel in diabetic patients who undergo DES implantation.

• 社団法人日本循環器学会の論文
• 2007-12-20

著者

• KIM Jong

  Department of Chemical Engineering, Dong A University

• Ahn Young

  The Heart Center Of Chonnam National University Hospital

• Chae In-Ho

  Cardiovascular Center, Seoul National University Bundang Hospital

• Chae In

  Heart Center Of Chonnam National University Hospital

• Kim Ju

  The Heart Center Of Chonnam National University Hospital

• Kim Ki

  Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Oral Science Res

• JEONG Myung

  Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute

• KIM Kye

  Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute

• AHN Youngkeun

  Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute

• JEONG Myung

  The Heart Center of Chonnam National University Hospital

• Kim Kun

  The Heart Center Of Chonnam National University Hospital

• Hur Seung

  Keimyung University

• Jeong Myung

  Yonsei University Wonju Hospital

• Oh Seouk

  Gachon University Gil Medical Center

• Hur Seung

  Heart Center of Chonnam National University Hospital

• Oh Seok

  Heart Center of Chonnam National University Hospital

• Ahn Tae

  Gill Heart Center Gachon Medical School

• Kim Yong

  Cardiovascular Research Institute Chonnam National University

• Jeong Jin-won

  Wonkwang University Hospital

• Kang Woong

  Gill Heart Center Gachon Medical School

• Bae Jang-ho

  Department Of Cardiology Konyang University Hospital

• Kim Jong

  Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University

• Oh Seok

  Wonkwang University Hospital

• NAM Chang

  Department of Physics, Korea Advanced Institute of Science and Technology

• Jeong Myung

  Heart Center Chonnam National University Hospital

• Chae In-ho

  Cardiovascular Center Seoul National University Hospital

• Jeong Jong

  Heart Center, Chonnam National University Hospital

• Park Chang-Gyu

  Department of Cardiology, Korea University Medical College

• Hur Seung-Ho

  Department of Cardiology, Keimyung University Dongsan Medical Center

• Oh Seok

  Department of Cardiology, Wonkwang University Hospital

• Jeong Jin-won

  Departments Of Cardiovascular Medicine Wonkwang University Hospital

• Ahn Youngkeun

  Heart Center Chonnam National University Hospital

• Hur Seung-ho

  Department Of Cardiology Keimyung University Dongsan Medical Center

• Nam Chang

  Department Of Cardiology Keimyung University Dongsan Medical Center

• Kim Ki

  Deparment Of Obstetrics & Gynecology College Of Medicine Pusan National University

• Park Chang-gyu

  Department Of Cardiology Korea University Medical College

• Kim Kyehun

  Heart Center Chonnam National University Hospital

• Kim Ki

  Department Of Cardiology Konyang University Hospital

• Kim Jong

  Department Of Agricultural Bio-resources National Academy Of Agricultural Science Rural Development

• Jeong Myung

  Department Of Cardiovascular Medicine Chonnam National University Medical School

• Kim Kye

  Heart Center of Chonnam National University Hospital, Cardiovascular Research Institute of Chonnam National University

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