Facilitated Skin Permeation of Oregonin by Elastic Liposomal Formulations and Suppression of Atopic Dermatitis in NC/Nga Mice
スポンサーリンク
概要
- 論文の詳細を見る
To develop an external preparation of oregonin (ORG) for the treatment of atopic dermatitis (AD), conventional creams (CC) and elastic liposomes (EL) containing ORG have been formulated and examined for their in vitro skin permeation properties and in vivo therapeutic efficacy assessments. EL, consisting of soybean phosphatidylcholine and Tween 80 (85 : 15 w/w %), were of flexible nanocarriers: they were about 130 nm in size and had a 4-fold greater deformability index than conventional liposomes. In a skin permeation study using a Franz diffusion cell mounted with depilated mouse skin, liposomal systems were superior to cream, revealing greater flux values. Both CC and EL were diversified with the addition of Trans-activating transcriptional activator (Tat) peptide, a sort of cell penetrating peptide, and subjected to in vivo efficacy evaluations in NC/Nga mice with AD-like lesions. On clinical observation for skin severity, rapid and profound improvement was observed in the treatment group with Tat-added liposomes (EL/T), showing a significant difference (p<0.05) versus Tat-added cream. The results indicated that EL/T treatment is effective for normalizing the immune-related responses and alleviating AD, evaluated as changes in the levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-4, immunoglobulin E (IgE), and eosinophils in skin or blood.
著者
-
LEE Min
Department of Internal Medicine, Chonnam National University Hospital
-
Choi Young
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Yonsei University College
-
PARK Sang
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine
-
Kang Myung
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
-
Eum Jae
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
-
Jeong Mi
Department of Dermatology, College of Medicine, Chung-Ang University
-
Choi Sun
Department of Pharmacognosy, College of Pharmacy, Chung-Ang University
-
Cho Hye
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
-
Cho Chin
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
-
Seo Seong
Department of Dermatology, College of Medicine, Chung-Ang University
-
Seo Seong
Department Of Dermatology College Of Medicine Chung-ang University
-
Choi Sun
Department Of Biomedical Laboratory Science College Of Biomedical Science And Engineering Inje Unive
-
Choi Young
Division Of Functional Genomics Jichi Medical University
-
Lee Min
Department Of Aeronautics And Astronautics Kyushu University
-
CHOI Young
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
関連論文
- Long-Term Clinical Course of Patients With Isolated Myocardial Bridge
- Facilitated Skin Permeation of Oregonin by Elastic Liposomal Formulations and Suppression of Atopic Dermatitis in NC/Nga Mice
- Protective Effects of Isoliquiritigenin Against Methamphetamine-Induced Neurotoxicity in Mice
- IS-57 Changes of Lipid Peroxidation and Protein Oxidation incubated by Antibiotics in the Maternal Venous Plasma of Preterm Labor with Intact Amniotic Membranes and Preterm Premature Rupture of Membranes(Group8 Perinatology1,International Session)
- IS-27 Single-port transumbilical laparoscopic approach for adenxal surgery in gynecology(Group4 Oncology4,International Session)
- Effect of Vessel Size on Lipid Content of Coronary Plaques Assessed by Integrated Backscatter Intravascular Ultrasound
- Investigation of Abnormal Drain Current Increase of Tunneling Field-Effect Transistors(Session 3A : Emerging Device Technology 2)
- Investigation of Abnormal Drain Current Increase of Tunneling Field-Effect Transistors(Session 3A : Emerging Device Technology 2)
- A TP53-truncating germline mutation (E287X) in a family with characteristics of both hereditary diffuse gastric cancer and Li-Fraumeni syndrome
- Early Statin Therapy Within 48 Hours Decreased One-Year Major Adverse Cardiac Events in Patients With Acute Myocardial Infarction
- Spinal cholinergic mechanism of the relieving effects of electroacupuncture on cold and warm allodynia in a rat model of neuropathic pain
- Electroacupuncture Potentiates the Antiallodynic Effect of Intrathecal Neostigmine in a Rat Model of Neuropathic Pain
- Substantial role of locus coeruleus-noradrenergic activation and capsaicin-insensitive primary afferent fibers in bee venom's anti-inflammatory effect
- Possible Role of Ca^ and cAMP on the Activity of Microsomal Ttriglyceride Transfer Protein in Rat Liver
- Screening of genes specifically activated in the pancreatic juice ductal cells from the patients with pancreatic ductal carcinoma
- Effects of androgen deprivation on chronic bacterial prostatitis in a rat model
- Effect of amniotic membrane on induced expression of iNOS by exposure to stimulants in HaCaT cells
- Expressions of β-defensins in human keratinocyte cell lines
- Case of regional lymphomatoid papulosis confined to the periorbital areas
- Changes of urinary nerve growth factor and prostaglandins in male patients with overactive bladder symptom
- Primary large cell neuroendocrine carcinoma of the urinary bladder
- Saeng-Maek-San, a Medicinal Herb Complex, Protects Liver Cell Damage Induced by Alcohol
- Effect of Green Tea Consumption on Endothelial Function and Circulating Endothelial Progenitor Cells in Chronic Smokers
- Sphingosine kinase inhibitor suppresses a T_h1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells
- A Study of LPE HgCdTe Wafer Characteristics Flattened with Single-Point Diamond Turning Method (先端デバイスの基礎と応用に関するアジアワークショップ(AWAD2005))
- A Study of LPE HgCdTe Wafer Characteristics Flattened with Single-Point Diamond Turning Method (先端デバイスの基礎と応用に関するアジアワークショップ(AWAD2005))
- Endophytic Colonization of Balloon Flower by Antifungal Strain Bacillus sp. CY22(Microbiology & Fermentation Technology)
- Three New Stereoisomers of Condensed Tannins from the Roots of Rosa multiflora
- Chromosome copy number analysis in screening for prognosis-related genomic regions in colorectal carcinoma
- Quantitative Analysis of Cannabinoids from Cannabis sativa Using ^1H-NMR
- Size effect of substitutional alkaline-earth elements on the electrical and structural properties of LaMnO3 films
- Microwave Assisted Facile One-Pot Synthesis of ^Re-Complex Using a Tetrahydroborate Exchange Resin. A Bifunctional Chelating Agent for Radiopharmaceuticals
- A Facile and Novel Route to ^Tc-labeled Antimony Sulfide Nanocolloid
- A Novel and Efficient Method for the Technetium-99m Labelling of Disulfide Compounds Using a Tetrahydroborate Exchange Resin
- Biocompatibility of Surface-Treated Pure Titanium and Ti-6A1-4V Alloy
- P-173 Pharmaceutical Interaction of Nimesulide and Antacid Complex
- NMR Metabolomic Analysis of Fecal Water from Subjects on a Vegetarian Diet(Pharmacognosy)
- P-243 NATURAL COX-2 INHIBITORS AND EFFECTS ON COLON CANCER CELLS
- First-line therapy with doxycycline in ocular adnexal mucosa-associated lymphoid tissue lymphoma : A retrospective analysis of clinical predictors
- Two Factor Authenticated Key Exchange (TAKE) Protocol in Public Wireless LANs(Fundamental Theories)
- BER Performance of Rectangular QAM with MRC over Nakagami-n Fading Channels(Wireless Communication Technologies)
- Sarcoptes scabiei in Infundibulum of Nodular Scabies
- Gaze Detection by Estimating the Depths and 3D Motion of Facial Features in Monocular Images
- S10-6 The status of clinical trial in Korea from hospital pharmacists' perspective(CJK (China-Japan-Korea) alliance for pharmaceutical health care and sciences 2010 Session 2 Pharmaceutical health care and sciences research)
- Pharmacologically Active Metabolites of Currently Marketed Drugs: Potential Resources for New Drug Discovery and Development
- Identification of the transforming activity of Indian hedgehog by retroviral expression screening
- Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screening
- Traditional Processing Strongly Affects Metabolite Composition by Hydrolysis in Rehmannia glutinosa Roots
- O-1-194 Cost Effectiveness of Laparoscopic Appendectomy in Korean Academic Hospital
- Fas, Fas-Associated Death Domain-Like Interleukin 1β-Converting Enzyme-Like Inhibitory Protein, and Apoptotic Features of Elderly Acute Myeloid Leukemia Based on Response to Induction Chemotherapy
- The Possible Role of Ca^ on the Activation of Microsomal Triglyceride Transfer Protein in Rat Hepatocytes(Pharmacology)
- Hodge structures on parabolic cohomology
- Metabolic Fingerprinting of Ephedra Species Using ^1H-NMR Spectroscopy and Principal Component Analysis
- Quantitative Analysis of Ephedrine Analogues from Ephedra Species Using ^1H-NMR
- Approximate Frequency Beam Command of the RPFSR System in the Ground Based Coordinate System
- Comparative study on the major element chemical compositions of Antarctic chondrites to those of non-Antarctic falls with reference to terrestrial weathering
- Dislocation Velocities in GaAs
- Quantitative Analysis of Bilobalide and Ginkgolides from Ginkgo biloba Leaves and Ginkgo Products Using ^1H-NMR
- Design of unique two-bit/cell SONOS flash memory device utilizing an advanced saddle structure(Session4A: Nonvolatile Memory)
- Design of unique two-bit/cell SONOS flash memory device utilizing an advanced saddle structure(Session4A: Nonvolatile Memory)
- Carcinosarcoma of the rectosigmoid colon in a 13-year-old girl
- Batch Production of High-Content Fructo-Oligosaccharides from Sucrose by the Mixed-Enzyme System of β-Fructofuranosidase and Glucose Oxidase
- Performance Analysis of MRC Diversity for Arbitrary Rectangular QAM Signals over Nakagami Fading Channels(Wireless Communication Technology)
- Carrier Suppression of Phase Modulated Beam Using Optical Cavity for Coherent Population Trapping Clock
- A Case of Necrotizing Sclerokeratitis and Endophthalmitis Caused by Beauveria bassiana
- Incidentally Proven Pulmonary "ALKoma"
- Design and Evaluation of Prostaglandin E_1 (PGE_1) Intraurethral Liquid Formulation Employing Self-Microemulsifying Drug Delivery System (SMEDDS) for Erectile Dysfunction Treatment(Biopharmacy)
- Skin Permeation Enhancement of Ascorbyl Palmitate by Liposomal Hydrogel (Lipogel) Formulation and Electrical Assistance(Biopharmacy)
- Impurity Effects on the Dislocation Velocity in Gallium Arsenide
- Fritillaria ussuriensis Extract Inhibits the Production of Inflammatory Cytokine and MAPKs in Mast Cells
- JKCF2-5 A synonymous variation in Protease-Activated Receptor-2 is associated with atopy in Korean children(Atopic eczema and related diseases,Free Paper Session 2,Japan-Korea-China Joint Symposium)
- アジアの生物学的精神医学の現状 : (1)韓国
- Association of a synonymous GAT3 polymorphism with antiepileptic drug pharmacoresistance
- 台湾より記載される新属新種 Ohirathous nantouensis(鞘翅目コメツキムシ科)
- Neural Stem Cells Modified by a Hypoxia-Inducible VEGF Gene Expression System Improve Cell Viability under Hypoxic Conditions and Spinal Cord Injury
- Femtosecond Pulses near 2μm from a Tm:KLuW Laser Mode-Locked by a Single-Walled Carbon Nanotube Saturable Absorber
- KLOTHO Gene Polymorphism Is Associated With Coronary Artery Stenosis but Not With Coronary Calcification in a Korean Population
- Effects of Hydrazine Surface Treatment on HgCdTe Long-Wavelength Infrared Photodiodes
- Hirsutenone Directly Blocks Human ether-a-go-go Related Gene K+ Channels
- ISP-9-4 Clinical outcomes using the total Prolift^ procedure in elderly women with advanced pelvic organ prolapse who desire uterine preservation(Group 9 Women's Health-2,IS Poster,International Session)
- Ultrafast Mode-Locked Fiber Laser Using a Waveguide-Type Saturable Absorber Based on Single-Walled Carbon Nanotubes
- Applicability of Graphene Flakes as Saturable Absorber for Bulk Laser Mode-Locking
- Three New Orcinol-Conjugated Hydrolysable Tannins from the Leaves of Cleyera japonica
- E1-2 Genetic variation in chitotriosidase is associated with atopy in Korean children(English Session 1)
- Ultrafast Mode-Locked Fiber Laser Using a Waveguide-Type Saturable Absorber Based on Single-Walled Carbon Nanotubes
- Propylthiouracil-induced Bronchiolitis Obliterans Organizing Pneumonia
- Applicability of Graphene Flakes as Saturable Absorber for Bulk Laser Mode-Locking
- Testicular tuberculosis in multidrug-resistant pulmonary tuberculosis