Pharmacologically Active Metabolites of Currently Marketed Drugs: Potential Resources for New Drug Discovery and Development
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概要
- 論文の詳細を見る
Biotransformation is the major clearance mechanism of therapeutic agents from the body. Biotransformation is known not only to facilitate the elimination of drugs by changing the molecular structure to more hydrophilic, but also lead to pharmacological inactivation of therapeutic compounds. However, in some cases, the biotransformation of drugs can lead to the generation of pharmacologically active metabolites, responsible for the pharmacological actions. This review provides an update of the kinds of pharmacologically active metabolites and some of their individual pharmacological and pharmacokinetic aspects, and describes their importance as resources for drug discovery and development.
- 公益社団法人 日本薬学会の論文
著者
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Kang Myung
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
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Lee Hyun
Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan Univ
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Lee Hyun
Division Of Endocrinology And Department Of Internal Medicine College Of Medicine Yonsei University
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Oh Seung
Division of Forest Science,Chonbuk National University
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Oh Seung
Division Of Forest Science Chonbuk National University
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Lee Jaehwi
Division Of Pharmaceutical Sciences College Of Pharmacy Chung-ang University
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SONG Woo
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
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SHIM Byung
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
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CHUNG Eun
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
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SOHN Yesung
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
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Lee Hyun
Division Of Cardiology Department Of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan Univers
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LEE Hyun
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
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OH Seung
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
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Lee Jaehwi
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University
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Shim Byung
Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea
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