Design and Evaluation of Prostaglandin E_1 (PGE_1) Intraurethral Liquid Formulation Employing Self-Microemulsifying Drug Delivery System (SMEDDS) for Erectile Dysfunction Treatment(Biopharmacy)
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概要
- 論文の詳細を見る
Liquid intraurethral prostaglandin E_1 (PGE_1) delivery system was developed using self-microemulsifying drug delivery system (SMEDDS). For this, pseudo-ternary phase diagrams were constructed and characterized. The viscosity of optimized formulation was increased gradually upon the addition of water and it was decreased from the water contents over 40%. With excessive mass of water, the present system transformed to a free flowing microemulsion. These results demonstrate that the present liquid PGE_1 SMEDDS formulation might stay in the urethra as a viscous sol or gel state with contacting the moisture of urethra and easily eliminated by urination. Draize test and long-term stability study revealed that the present system would be safe and PGE_1 would be stable for more than one year at 4℃, respectively. In the feline animal model, SMEDDS formulation was as effective as PGE_1 intracavernosal injections in terms of ICP (intracavernosal pressure), penile length increment, and erection sustaining time was more elongated than PGE_1 injections. Therefore, SMEDDS was considered as a promising PGE_1 intraurethral liquid formulation for erectile dysfunction treatment.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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Choi Young
Division Of Functional Genomics Jichi Medical University
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Lee Jaehwi
Division Of Pharmaceutical Sciences College Of Pharmacy Chung-ang University
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Choi Young
Division Of Pharmaceutical Sciences College Of Pharmacy Chung-ang University
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LEE Sangkil
Department of Pharmaceutical Engineering, College of Engineering, Inje University
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Lee Sangkil
Department Of Pharmaceutical Engineering College Of Engineering Inje University
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