Quantitative Analysis of Ephedrine Analogues from Ephedra Species Using ^1H-NMR

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概要

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• Four ephedrine analogues such as ephedrine, pseudoephedrine, methylephedrine, and methylpseudo-ephedrine were determined by ^1H-NMR from Ephedra species. In the region of δ 5.0-4.0, the signals of H-1 attached to the same carbon with a hydroxyl, were well separated from each other in CDCl_3. The amount of each alkaloid was calculated by the relative ratio of the intensity of H-1 signal to the known amount of internal standard, 200 μg of anthracene. This method allows rapid determination of the quantity of four ephedrine alkaloids from Ephedra species. The amount of these alkaloids was in the range of 1.0-2.0% of dry weight depending on the plant materials.

• 公益社団法人日本薬学会の論文
• 2003-12-01

著者

• Choi Young

  Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Yonsei University College

• Choi Y

  Leiden Univ. Leiden Nld

• Kim Hye

  Division Of Pharmacognosy Institute Of Biology Leiden University

• Choi Young

  Division Of Functional Genomics Jichi Medical University

• VERPOORTE Robert

  Division of Pharmacognosy, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories

• Verpoorte R

  Leiden Univ. Leiden Nld

• Verpoorte Robert

  Division Of Pharmacognosy Center For Bio-pharmaceutical Sciences Leiden University

• Chang Wen-te

  School Of Chinese Medicine Resources China Medical University

• CHANG Wen-Te

  Division of Pharmacognosy, Institute of Biology, Leiden University

• Kim Hye

  Division Of Nephrology Department Of Internal Medicine Korea University Anam Hospital Korea Universi

• KIM Hye

  Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine

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