Some Accounts of Variation (Heterogeneity and / or Instability) in Secondary Metabolites Production by Plant Cell Cultures

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In plant cell cultures, the high production trait is generally accepted to be often unstable during a long term culture. This phenomenon obviously raises a major problem for the commercial production of secondary metabolites by plant cell cultures. The hypothesis (genetic variation and cell selection theory) was proposed to explain the variation (heterogeneity and/or instability) for the production of secondary metabolites during the culture period, and the possible mechanisms for the variation were discussed from the view point of genetic variation and cell selection. First hypothesis (genetic variation) is that genetic variation produces new variants having not or low producing types of cells during culture period. This mechanism would explain why a culture derived from a single cell will become a genetically heterogeneous cell population (cell heterogeneity) and the productivity is changeble considerably during culture period. In second hypothesis (cell selection) the variation (instability) results from the selection of not or low producing types of cells in the population that pre-existed in a culture. This mechanism would explain that the productivity is gradually decreased and or lost, or stabilized to a given level over a long successive culture. Actually in plant cell cultures, both of these mechanisms are assumed to operate during the culture period. Furthermore, some suggestins were made to obtain stable and high producing cell lines or cultures.
金城学院大学の論文
1993-03-20

Some Accounts of Variation (Heterogeneity and / or Instability) in Secondary Metabolites Production by Plant Cell Cultures

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