Incidentally Proven Pulmonary "ALKoma"
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概要
- 論文の詳細を見る
Genetic alterations of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inversion were recently found in lung cancer. A 39-year-old woman with multiple brain metastases and bulky mediastinal lymph node metastases was admitted. Biopsy from her supraclavicular lymph nodes was performed to differentiate the diagnosis between lymphoma and lung cancer. Pathologically, the lymph nodes had a feature of adenocarcinoma. On the other hand, the commercially available chromosomal fluorescent in situ hybridization (FISH) analysis showed split signals of ALK, which was confirmed to be the EML4-ALK inversion. The commercial-based ALK FISH is useful for screening pulmonary ALKoma.
著者
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Mano Hiroyuki
Division of functional genomics, Jichi Medical University
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Choi Young
Division Of Functional Genomics Jichi Medical University
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Miyamoto Hitoshi
Department Of Architecture And Civil Engineering Kobe University
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Seto Takashi
Department Of Thoracic Oncology Kyushu Cancer Center
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Ondo Kaoru
Department Of Surgery And Science Graduate School Of Medical Sciences Kyushu University
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Soda Manabu
Division Of Functional Genomics Jichi Medical University
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Sugio Kenji
Department Of Surgery And Science Graduate School Of Medical Sciences Kyushu University
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Mano Hiroyuki
Division Of Cardiovascular Medicine Department Of Medicine Jichi Medical School
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Osoegawa Atsushi
Department Of Surgery And Science Graduate School Of Medical Sciences Kyushu University
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Kometani Takuro
Department Of Surgery And Science Graduate School Of Medical Sciences Kyushu University
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Hirai Fumihiko
Department Of Thoracic Oncology Kyushu Cancer Center
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CHOI Young
Division of Functional Genomics, Jichi Medical University
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ICHINOSE YUKITO
Department of Chest Surgery , National Kyushu Cancer Center
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Kometani Takuro
Department of Thoracic Oncology, National Kyushu Cancer Center
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Sugio Kenji
Department of Thoracic Oncology, National Kyushu Cancer Center
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Nosaki Kaname
Department of Thoracic Oncology, National Kyushu Cancer Center
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Seto Takashi
Department of Medical Oncology, Tokai University School of Medicine
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Miyamoto Hitoshi
Department of Thoracic Oncology, National Kyushu Cancer Center
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