Long Term Pulmonary Toxicity of Indium Arsenide and Indium Phosphide Instilled Intratracheally in Hamsters
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概要
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We examined the long-term toxicological effects of III-V semiconductor particles on laboratory animals. Eight-week-old male Syrian golden hamsters were given 4 mg/kg indium arsenide(InAs)or 3 mg/kg indium phosphide(InP)particles, both containing 2.4 mg/kg as indium, intratracheally twice a week for 8 weeks. Control hamsters were given only a vehicle, phosphate buffer solution. Over a 2-yr period, these animals were euthanized serially and the biological effects were determined. Weight gain was significantly suppressed in both InAs and InP groups, compared to the control group, with greater suppression in the InAs group. The serum indium concentration in the InAs group was about twice as high as that in the InP group, in each period. Histopathologically, severe pulmonary inflammation and localized lesions with bronchioloalveolar cell hyperplasia were present in both InAs and InP groups from just after the last administration. The localized lesions gradually transformed to proteinosislike lesions with periodic acid Schiff reagent positive exudation after 16 wk. By means of immunostaining of proliferating cell nuclear antigen and argyrophilic proteins associated with nucleolar organizer regions staining, proliferative activities were evidenced in the localized lesions at each time and were noticeable in their early stage. K-ras, a known oncogene, was not mutated in association with these lesions. In conclusion, InAs and InP particles caused severe systemic toxicity and pulmonary localized hyperplastic lesions with proliferative activity were derived via the respiratory route. Neoplastic change was nil even in a 2-yr observation period.
- 社団法人日本産業衛生学会の論文
著者
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Yamazaki Koji
Department of Cardiology, Saitama Cardiovascular and Respiratory Center
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HIRATA Miyuki
Department of Hygiene, Graduate School of Medical Sciences, Kyushu University
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TANAKA Akiyo
Department of Hygiene, Graduate School of Medical Sciences, Kyushu University
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INOUE Naohide
Department of Hygiene, Graduate School of Medical Sciences, Kyushu University
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Yamazaki Kazuhito
Department Of Pathology School Of Medicine Keio University
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SUGIO Kenji
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
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SUGIMACHI Keizo
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
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Yamazaki Koji
産業医科大学 2外
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OMURA Minoru
Department of Hygiene
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MAKITA Yuji
Department of Hygiene
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Omura M
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Sugimachi Keizo
The Department Of Surgery And Science Graduate School Of Medical Sciences Kyushu University
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Yasumoto K
Second Department Of Surgery School Of Medicine University Of Occupational And Environmental Health
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Yamazaki Koji
Department Of Cardiology Saitama Cardiovascular And Respiratory Center
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Yamazaki Kazuto
The Department Of Surgery And Science Graduate School Of Medical Sciences Kyushu University
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Makita Yuji
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Sugio Kenji
Department Of Surgery And Science Graduate School Of Medical Sciences Kyushu University
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Hirata Mari
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Hirata Miyuki
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Hirata Miyuki
Department Of Clinical Labolatory Yamagata University School Of Medicine
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Sugimachi Keizo
Department Of Chest Surgery National Kyushu Cancer Center Graduate School Of Medicine Kyushu Univers
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Sugimachi Keizo
Second Department Of Surgery Kyushu University School Of Medicine
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Endo Y
Japan Soc. For Occupational Health
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Inoue Naohide
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Inoue Naohide
Department Of Hygiene Faculty Of Medicine Kyushu University
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Tanaka Akiyo
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
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Yamauchi Tuneyuki
Occupational Health Research And Development Center Japan Industrial Safety And Health Association:j
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Yamazaki Koji
Department Of Cardiology Department Of Internal Medicine The Jikei University School Of Medicine Kas
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INOUE Naohide
Department of Environmental Toxicology, School of Medicine, University of Occupational and Environmental Health
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