Systemic Effects of Orally Administered p, p'-DDE on Immature Male Wistar Rats during Pubertal Period

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概要

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• Systemic effects of p, p'-DDE (1, 1-dichloro-2, 2 bis (p-chlorophenyl) ethylene ; DDE) on immature male rats were investigated in pubertal Wistar rats after oral administration of DDE. Special rat chow containing 125 ppm DDE (approximately 10 mg/kg DDE) had been administered daily for 42 d since 6 wk of age and its effects had been observed until 12 wk of age. The administration of DDE did not produce any overt signs of toxicity. Neither physical development nor sexual maturation was affected, and serum biochemistry was not impaired at the dose used in this experiment. Moreover, the male reproductive organs and epididymal sperm count were not affected by the administration of DDE during the pubertal period. Our results showed that even immature male rats were resistant to DDE exposure at the daily dose of ca. 10 mg/kg, but metabolic and immunological changes still remained uncertain. Further investigation should be conducted to reveal all the effects of DDE on immature male rats.

• 社団法人日本産業衛生学会の論文

著者

• HIRATA Miyuki

  Department of Hygiene, Graduate School of Medical Sciences, Kyushu University

• TANAKA Akiyo

  Department of Hygiene, Graduate School of Medical Sciences, Kyushu University

• INOUE Naohide

  Department of Hygiene, Graduate School of Medical Sciences, Kyushu University

• Nakano Makiko

  Department Of Preventive Medicine And Public Health Keio University School Of Medicine

• OMURA Minoru

  Department of Hygiene

• MAKITA Yuji

  Department of Hygiene

• Omura M

  Department Of Hygiene Graduate School Of Medical Sciences Kyushu University

• Romero Yesid

  Department Of Hygiene Graduate School Of Medical Sciences Kyushu University

• Makita Yuji

  Department Of Hygiene Graduate School Of Medical Sciences Kyushu University

• Hirata Mari

  Department Of Hygiene Graduate School Of Medical Sciences Kyushu University

• Hirata Miyuki

  Department Of Hygiene Graduate School Of Medical Sciences Kyushu University

• Hirata Miyuki

  Department Of Clinical Labolatory Yamagata University School Of Medicine

• MATSUURA Toshiaki

  Department of Hygiene, Graduate School of Medical Sciences, Kyushu University

• OGATA Rika

  Department of Hygiene, Graduate School of Medical Sciences, Kyushu University

• Ogata Rika

  Department Of Hygiene Graduate School Of Medical Sciences Kyushu University

• Ogata Rika

  Department Of Gynecology And Obstetrics Faculty Of Medicine Kyushu University

• Endo Y

  Japan Soc. For Occupational Health

• Inoue Naohide

  Department Of Hygiene Graduate School Of Medical Sciences Kyushu University

• Inoue Naohide

  Department Of Hygiene Faculty Of Medicine Kyushu University

• Tanaka Akiyo

  Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University

• Matsuura Toshiaki

  Department Of Hygiene Graduate School Of Medical Sciences Kyushu University

• INOUE Naohide

  Department of Environmental Toxicology, School of Medicine, University of Occupational and Environmental Health

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