Urinary Excretion of TTCA after Intake of brassica Vegetables

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Aim: Recent studies have made it clear that brass/ca vegetables contain 2-thiothiazolidine-4-carboxylic acid (TTCA), which is the most widely used biological monitoring index of exposure to carbon disulfide (05_2). This study aimed to assess the time-course of TTCA excretion in urine (TTCA-U) after eating brassica vegetables. Methods: After a 1-d break from eating brass/ca vegetables, ten volunteers (6 males and 4 females) ingested 100 grams of chopped raw cabbage containing 4.3 mg/kg of TTCA, and the TTCA concentration in urine samples was determined over 24 h. TTCA concentrations in brass/ca vegetables purchased from a local supermarket were also measured. Results: TTCA-U reached peak concentrations 3-9 h after cabbage intake, gradually decreased, and was below the detection limit (<0.1 mg/ I) in 8 of 10 volunteers in the last urine samples. The total amount of TTCA excreted in 24 h ranged from 0.19 to 0.42 mg, and half of the total TTCA was excreted within 6.5 h on average (range: 4.5-10.1). The excretion profiles of young and middle-aged volunteers seemed to differ, but not those of young males and young females. TTCA was detected in both raw and boiled cabbage, Japanese radish, turnip, and broccoli, but was not detected in Chinese cabbage or chingentsuai. Conclusion: TTCA-U may be overestimated as an index of CS_2 exposure when brassica vegetables are ingested within approximately 24 h before collection of the urine sample.
社団法人日本産業衛生学会の論文

Urinary Excretion of TTCA after Intake of brassica Vegetables

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