Four-Week Inhalation Toxicity Study of 2, 2-Dichloro-1, 1, 1-trifluoroethane(HCFC-123) in Guinea Pigs
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概要
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Four-Week Inhalation Toxicity Study of 2, 2-Dichloro-1, 1, 1-trifluoroethane(HCFC-123) in Guinea Pigs:Isamu KABE, et al. Department of Preventive Medicine and Public Health, School of Medicine, Keio University-Groups of eight male Hartley guinea pigs were exposed to 30, 100 or 300 ppm 2, 2-dichloro-1, 1, 1-trifluoroethane(HCFC-123) by inhalation for 6 hours a day for 4 wk. All the animals were sacrificed 48 h postexposure. Guinea pigs exposed to 300 ppm HCFC-123 had significantly lower body weight and the weight gain than controls, but there was no significant difference and no tendency in absolute and relative organ weight. ICDH, ALT and AST, which were the most sensitive indicators of halothane-induced liver injury, did not differ significantly between exposed groups and controls. In the 100 ppm group, a few vacuolar fatty changes in the portal area(zone 1) were identified. In the 300 ppm group, severe fatty degeneration was observed in the portal and intermediate areas, partly centrilobule, and the incidence increased significantly compared to the controls. On the other hand, there was no histopathological change in the control or 30 ppm groups. No increase in any of the liver peroxisomal enzymes(AOX, PT, catalase) was seen in male guinea pigs exposed to HCFC-123. The activity of hepatic ALDH was significantly decreased in the 300 ppm exposed group, suggesting that HCFC-123 or its metabolite inhibited ALDH activity. In conclusion, inhalation exposure to 100 ppm or more of HCFC-123 for 4 wk produced nonfatal liver change in guinea pigs, namely hepatic fatty changes predominantly in the portal area(zone 1) without any increase in AST, ALT or ICDH. The no-observed-adverse-effect level(NOAEL) of HCFC-123 for four wk in guinea pigs may be 30 ppm. Peroxisome proliferation, which may result in hepatocellular tumor induction, was not observed in guinea pigs exposed to HCFC-123.
- 社団法人日本産業衛生学会の論文
著者
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NAKAJIMA TAMIE
Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine
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Nakajima Tamie
Department Of Occupational And Environmental Health Nagoya University Graduate School Of Medicine
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Takebayashi T
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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NISHIWAKI Yuji
Department of Preventive Medicine and Public Health, Keio University School of Medicine
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TAKEBAYASHI Toru
Department of Preventive Medicine and Public Health, Keio University School of Medicine
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OMAE Kazuyuki
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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SAITOH Takehito
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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TANAKA Shigeru
Faculty of Hygienic Technology, School of Allied Health Sciences, Kitasato University
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KABE Isamu
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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IKEDA Eiji
Department of Pathology, School of Medicine, Keio University
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SAITO Takehito
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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MIYAUCHI Hiroyuki
The Association of Industrial Health
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ENDO Yuichi
Department of Health Administration, Furukawa Electric Col.Ltd.
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Omae Kazuyuki
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Omae Kazuyuki
慶応義塾大学 医学部衛生学公衆衛生学
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Omae Kazuyuki
慶應義塾大学医学部衛生学公衆衛生学教室
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Omae Kazuyuki
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Omae Kazuyuki
東京医科歯科大学難治疾患研究所 分子疫学
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Nakano Makiko
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Takebayashi Toru
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Ikeda Eiji
Department Of Electrical Engineering Faculty Of Engineering Hokkaido University
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Oda Kenichi
Department Of Preventive Medicine & Public Health School Of Medicine Keio University
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Hirata Miyuki
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Takahashi Ken
Japan Industrial Safety And Health Association
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Endo Y
Japan Soc. For Occupational Health
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Endo Yuichi
Department Of Biochemistry 2nd Division Fukushima Medical College
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Nishiwaki Yuji
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Nishiwaki Yuji
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Nishiwaki Yuji
Department Of Preventive Medicine And Public Health Keio University
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Nakajima Tamie
Department Of Hygiene School Of Medicine Shinshu University
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Tanaka Akiyo
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
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Yamauchi Tuneyuki
Occupational Health Research And Development Center Japan Industrial Safety And Health Association:j
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Kabe Isamu
Department Of Preventive Medicine And Public Health School Of Medicine Keio University:department Of
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Saito Takehito
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Ikeda Eiji
Department Of Pathology School Of Medicine Keio University
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Ikeda Eiji
Department Of Earth And Planetary Sciences Faculty Of Science Kyushu University
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Tanaka Shigeru
Department Of Public Health School Of Human Life Sciences Jumonji University
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NISHIWAKI Yuji
Department of Environmental and Occupational Health, Faculty of Medicine, Toho University
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Nishiwaki Yuji
Department of Environmental and Occupational Health, School of Medicine, Toho University
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Takebayashi Toru
Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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