Association between Smoking Habits and Dopamine Receptor D2 Taql A A2 Allele in Japanese Males : a Confirmatory Study
スポンサーリンク
概要
- 論文の詳細を見る
Our previous study showed that A2 allele of dopamine D2(DRD2)Taql A polymorphism related to smoking habits, which was opposed to the results of studies for Caucasians.In order to confirm our finding, a similar study was conducted for the first-visit outpatients of Aichi Cancer Center Hospital, who participated in HERPACC-II(Hospital-based Epidemiologic Research Program at Aichi Cancer Center II).Among consecutive 1, 577 first-visit patients between November 2000 and February 2001, 800 patients provided a 7m1 of peripheral blood.Smoking habit data were available for 798 participants. Excluding five participants aged < 20 years or ≥080 years, the remaining 793 participants(346 males and 447 females)were analyzed.The DRD2 genotype was determined by a new method, polymerase chain reaction with confronting two-pair primers(PCR-CTPP).In males, current smokers were 35.3% of individuals with A1A1 genotype, 43.1% of individuals with A1A2 genotype, and 57.0% of individuals with A2A2 genotype, while in females, they were 19.6%, 14.6%, and 10.9%, respectively.Age-adjusted odds ratio(OR)of current smoking relative to A1A1 was 1.61(95% confidence interval, 0.71-3.46)for A1A2 and 2.32(1.02-5.29)for A2A2 in males, and 0.72(0.32-1.61)and 0.51(0.22-1.18)in females, respectively.The present study indicated that Japanese males with A2A2 genotype have a higher risk of being current smokers.No association for Japanese females suggested that female smoking behavior is differently affected in biological and/or psychological manner.J Epidemiol2002;12:297-304.
- 日本疫学会の論文
著者
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Takahashi Takashi
Division of Molecular Carcinogenesis, Department of Oncology, Center for Neurological Diseases and C
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Takebayashi T
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Ichimiya Hitoshi
Division Of Surgery Hamanomachi General Hospital
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Ito Hidemi
愛知県がんセンター研究所 疫学･予防部
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ITO Hidemi
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
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TAJIMA Kazuo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
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SAITO Toshiko
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
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HAMAJIMA Nobuyuki
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
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YOSHIDA Kimihide
Department of Pulmonary Medicine, Aichi Cancer Center Hospital
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Kato T
Department Of Gastroenterological Surgery Aichi Cancer Center Hospital
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Matsuo Keitaro
愛知県がんセンター研究所 疫学･予防部
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Matsuo Keitaro
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
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Ando Masahiko
Department Of Pediatric Cardiology The Heart Institute Of Japan Tokyo Women's Medical College
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Hamajima N
Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua
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Hamajima Nobuyuki
愛知県がんセンター研究所 疫学･予防部
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Kuroisi Tetsuo
The Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
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Takezaki T
Department Of International Island And Community Medicine Graduate School Of Medical And Dental Scie
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Takezaki Toshiro
愛知県がんセンター研究所 疫学予防部
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Takahashi Ken
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Ito Hidemi
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
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Matsuo Keitaro
Division Of Epidemiology And Prevention Aichi Cancer Center
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Saito Toshiko
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
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Ando Manabu
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
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Hamajima Nobuyuki
Division Of Epidemiology Aichi Cancer Center Research Institute
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Iwata H
Department Of Breast Oncology Aichi Cancer Center Hospital
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Kano Mayuko
Medical Student Of Nagoya University School Of Medicine Department Of Preventive Medicine-biostatist
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Yoshida Kimihide
Department Of Pulmonary Medicine Aichi Cancer Center Hospital
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Sakamoto Tatsuhiko
Fukuoka Prefectural Government Asakura Health Welfare Environment Office
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Tajima Kazuo
Division Of Epidemiology Aichi Cancer Center Research Institute
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Kato Motoichiro
Department Of Neuropsychiatry Tokyo Medical And Dental University Ichikawa General Hospital
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Iwata Hiroji
Department Of Breast Surgery Aichi Cancer Center Hospital
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Iwase Hirotaka
Department Of Surgery Ii Breast And Endocrine Surgery Nagoya City University Medical School
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Takahashi Ken
Japan Industrial Safety And Health Association
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Sakai Takahiro
Fukuoka Prefectural Government Asakura Health Welfare Environment Office
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Matsuo Keitaro
Department Of Epidemiology And Prevention Aichi Cancer Center Research Institute
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Iwata H
Department Of Internal Medicine And Molecular Science Nagoya City University Graduate School Of Medi
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Suchi Taizan
Department Of Medical Oncology And Immunology Nagoya City University Graduate School Of Medical Scie
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Suzuki Takeshi
Department Of Medical Oncology And Immunology Nagoya City University Graduate School Of Medical Scie
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Hirabayashi Noriyuki
Department Of Hematology Nagoya Daini Red Cross Hospital
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Ando Masahiko
Department Of Pediatric Cardiology Heart Institute Of Japan Tokyo Women's Medical College
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Ando Masahiko
Department Of Cardiothoracic Surgery The University Of Tokyo
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Ando Masahiko
Department Of Artificial Organ National Cardiovascular Center Research Institute
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Takahashi Takashi
Division Of Infectious Diseases Advanced Clinical Research Center Institute Of Medical Science Unive
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Matsuo Keitaro
Division of Cardiology, Nippon Medical School
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