A Limited Association of OGG1 Ser326Cys Polymorphism for Adenocarcinoma of the Lung

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概要

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• The 8-oxoguanine DNA glycosylase (OGG1) repairs DNA by removing 8-hydroxyguanine, a highly mutagenic oxidative DNA adduct.Recently, the gene for OGG1 was cloned and several polymorphisms have been reported.Because environmental carcinogens produce 8hydroxyguanine residues that potentially cause oncogenic mutations by mismatching to this modified base, the capacity to repair these lesions can be involved in cancer susceptibility.This study investigated the association between OGG1 Ser326Cys polymorphism and risk of the lung adenocarcinoma for Japanese by a prevalent case-control study in Japan.The subjects comprised 138 cases and 241 non-cancer outpatients as controls.OGG1 gene polymorphism was genotyped by a PCR-CTPP (polymerase chain reaction with confronting two-pair primers) method.The distribution of OGG1 Ser326Cys genotype among controls (Ser/Ser, 28.3%; Ser/Cys, 49.2%;and Cys/Cys, 22.5%) was not different from that among cases (Ser/Ser, 29.0%; Ser/Cys, 51.4%;and Cys/Cys, 24.0%).The sex-age adjusted odds ratio (OR) was 1.06 with 95% confidence interval (CI) 0.64-1.76 for Ser/Cys genotype and 0.81 with 0.44-1.52 for Cys/Cys genotype.The ORs according to the interval between diagnosis and study enrollment were also examined because the polymorphism was a potential prognostic factor of lung cancer.The ORs of Ser/Cys and Cys/Cys genotypes in the cases less than 3 years after diagnosis were higher than overall ORs;1.86 (95%Cl, 0.91-3.77), and 1.46 (0.64-3.35), respectively.The OR for smoking was not statistically different among genotype, though the sample size was too small to detect even a moderate interaction.This study supported the first study by Sugimura et al (Cancer Epidemiol Biomarkers Prev, 1999;8:669-674), that the association of OGG1 Ser326Cys polymorphism was limited for the risk of lung adenocarcinoma. J Epidemiol, 2002;12:258-265

著者

• Takebayashi T

  Department Of Preventive Medicine And Public Health School Of Medicine Keio University

• Ichimiya Hitoshi

  Division Of Surgery Hamanomachi General Hospital

• Ito Hidemi

  愛知県がんセンター研究所 疫学･予防部

• ITO Hidemi

  Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute

• MITSUDOMI Tetsuya

  Department of Thoracic Surgery, Aichi Cancer Center Central Hospital

• TAJIMA Kazuo

  Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute

• HAMAJIMA Nobuyuki

  Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute

• HATOOKA Shunzo

  Department of Thoracic Surgery, Aichi Cancer Center Hospital

• SUYAMA Motokazu

  Department of Thoracic Surgery, Aichi Cancer Center Hospital

• SATO Shigeki

  2^ Department of Internal Medicine, Nagoya City University School of Medicine

• UEDA Ryuzo

  2^ Department of Internal Medicine, Nagoya City University School of Medicine

• Mitsudomi Tetsuya

  愛知県がんセンター中央病院 胸部外科

• Mitsudomi Tetsuya

  Department Of Thoracic Surgery Aichi Cancer Center Research Institute

• Mitsudomi Tetsuya

  岡山大学 医歯薬学総合研究科腫瘍･胸部外科

• Matsuo Keitaro

  愛知県がんセンター研究所 疫学･予防部

• Matsuo Keitaro

  Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute

• Shinjo Samuel

  Japanese Brazilian Health Professional Volunteer Group

• Shinjo S

  Japanese Brazilian Health Professional Volunteer Group

• Shinjo Samuel

  名古屋大学 医学系研究科予防医学

• Hamajima N

  Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua

• Hamajima Nobuyuki

  愛知県がんセンター研究所 疫学･予防部

• Suyama Motokazu

  Aichi Hospital, Okazaki

• Kuroisi Tetsuo

  The Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute

• Takezaki T

  Department Of International Island And Community Medicine Graduate School Of Medical And Dental Scie

• Takezaki Toshiro

  愛知県がんセンター研究所 疫学予防部

• Takezaki Toshiro

  Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute

• Takahashi Ken

  Department Of Preventive Medicine And Public Health School Of Medicine Keio University

• Ueda Ryuzo

  Department Of Internal Medicine And Molecular Science Nagoya City University Graduate School Of Medi

• Sasaki Satoshi

  2^<nd> Department Of Internal Medicine Nagoya City University School Of Medicine

• Ito Hidemi

  Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute

• Matsuo Keitaro

  Division Of Epidemiology And Prevention Aichi Cancer Center

• Hamajima Nobuyuki

  Division Of Epidemiology Aichi Cancer Center Research Institute

• Iwata H

  Department Of Breast Oncology Aichi Cancer Center Hospital

• Kano Mayuko

  Medical Student Of Nagoya University School Of Medicine Department Of Preventive Medicine-biostatist

• Suyama Motokazu

  Aichi Hospital Okazaki

• Suyama Motokazu

  Department Of Chest Surgery Aichi Cancer Center Aichi Hospital

• Mitsudomi Tetsuya

  Department Of Thoracic Surgery Aichi Cancer Center

• Hatooka Shunzo

  Department Of Thoracic Surgery Aichi Cancer Center Hospital

• Ueda Ryuzo

  Department Of Internal Medicine And Molecular Science Nagoya City University Graduate School Of Medi

• Tajima Kazuo

  Division Of Epidemiology Aichi Cancer Center Research Institute

• Kato Motoichiro

  Department Of Neuropsychiatry Tokyo Medical And Dental University Ichikawa General Hospital

• Iwata Hiroji

  Department Of Breast Surgery Aichi Cancer Center Hospital

• Iwase Hirotaka

  Department Of Surgery Ii Breast And Endocrine Surgery Nagoya City University Medical School

• Takahashi Ken

  Japan Industrial Safety And Health Association

• Sato Shigeki

  Department Of Internal Medicine And Molecular Science Nagoya City University Graduate School Of Medi

• Matsuo Keitaro

  Department Of Epidemiology And Prevention Aichi Cancer Center Research Institute

• Iwata H

  Department Of Internal Medicine And Molecular Science Nagoya City University Graduate School Of Medi

• Hirabayashi Noriyuki

  Department Of Hematology Nagoya Daini Red Cross Hospital

• Ueda Ryuzo

  2nd Department of Internal Medicine,Nagoya City University School of Medicine

• Matsuo Keitaro

  Division of Cardiology, Nippon Medical School

• Hatooka Shunzo

  Department of Thoracic Surgery , Aichi Cancer Center Hospital

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