Association between Smoking Habits and Tryptophan Hydroxylase Gene C218A Polymorphism among the Japanese Population
スポンサーリンク
概要
- 論文の詳細を見る
BACKGROUND: Genetic polymorphisms have proposed a new insight in smoking behavior. Genes in serotonin system are one of the candidates because of serotonins role in mood regulation. A polymorphism C218A in intron 7 of the tryptophan hydroxylase (TPH) gene has been hypothesized in relation to smoking predisposition.METHODS: We examined the association on two Japanese populations: one was from the first-visit outpatients of Aichi Cancer Center Hospital during 3-month period between April and June, 2001 (N=591), and the second was from the examinees who attended a health checkup program supported by the Nagoya municipal government in 2000 (N=446). Written documents on informed consent were obtained and lifestyle questionnaires were recorded. TPH C218A genotypes were determined by the polymerase chain reaction with confronting two-pair primers (PCR-CTPP) method.RESULTS: The frequencies of the C- and A-allele were 52% and 48%, respectively, which was in Hardy-Weinberg equilibrium. As for current smoking status, no associations were statistically observed. It was, however, indicated that smokers with A/A genotype started smoking earlier in their life. Among male health examinees, mean ages at starting smoking were 18.7 (A/A), 19.9 (C/A), and 22.4 years (C/C), (P<0.01). Also, on the Aichi Cancer Center Hospital subjects aged 60 and older, mean ages were 19.0 (A/A), 20.2 (C/A), and 20.3 years (C/C) for males and 22.3 (A/A), 31.0 (C/A), and 33.0 years (C/C) for females (P<0.05).CONCLUSIONS: The present study demonstrated that the TPH C218A polymorphism in intron 7 had no association with current smoking status in Japanese population. The hypothesis of early smoking initiation of A/A genotype was partially in agreement.
- 日本疫学会の論文
著者
-
TAMAKOSHI Akiko
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Gradu
-
Ichimiya Hitoshi
Division Of Surgery Hamanomachi General Hospital
-
Ito Hidemi
愛知県がんセンター研究所 疫学･予防部
-
Ito H
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
-
TAJIMA Kazuo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
-
HIROSE Kaoru
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
-
HAMAJIMA Nobuyuki
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Gradu
-
Hirose Kaoru
名古屋大学 医学部産婦人科
-
Tamakoshi Akiko
Department Of Health Science Shiga University Of Medical Science
-
Kato T
Department Of Gastroenterological Surgery Aichi Cancer Center Hospital
-
Hamajima N
Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua
-
Hamajima Nobuyuki
愛知県がんセンター研究所 疫学･予防部
-
Hamajima Nobuyuki
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
-
Tajima K
Aichi Cancer Center Research Institute
-
Hirose Kaoru
愛知県がんセンター研究所 疫学･予防部
-
Hirose K
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
-
Kuroisi Tetsuo
The Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
-
MIZUNO Shoichi
Group of Epidemiology and Health Promotion, Tokyo Metropolitan Institute of Gerontology
-
ITO Hidemi
Department of Internal Medicine and Molecular Science, Nagoya City University, Graduate School of Me
-
Hirose Kaoru
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
-
Hirose K
Department Of Planning And Information Aichi Prefectural Institute Of Public Health
-
Hamajima Nobuyuki
Department Of Preventive Medicine Aichi Cancer Center Research Institute
-
Hamajima Nobuyuki
Department Of Preventive Medicine
-
Mizuno Shoichi
Group Of Epidemiology And Health Promotion Tokyo Metropolitan Institute Of Gerontology
-
Ito Hidemi
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
-
Iwata H
Department Of Breast Oncology Aichi Cancer Center Hospital
-
Nakagawa H
Department Of Public Health Kanazawa Medical University
-
Kawase Takakazu
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
-
Tamakoshi Akiko
Department Of Clinical Trials National Center For Geriatrics And Gerontology
-
Tajima Kazuo
Division Of Epidemiology Aichi Cancer Center Research Institute
-
Iwata Hiroji
Department Of Breast Surgery Aichi Cancer Center Hospital
-
Iwase Hirotaka
Department Of Surgery Ii Breast And Endocrine Surgery Nagoya City University Medical School
-
Iwata H
Department Of Internal Medicine And Molecular Science Nagoya City University Graduate School Of Medi
-
Hirabayashi Noriyuki
Department Of Hematology Nagoya Daini Red Cross Hospital
-
Hirose Kaoru
Division Of Epidemiology
-
Hatsumi Naoko
Leukemia Research Center Saiseikai Maebashi Hospital
-
Hamajima Nobuyuki
Department of Epidemiology and Public Health, Kanazawa Medical University
関連論文
- Association of Serum Phytoestrogen Concentration and Dietary Habits in a Sample Set of the JACC Study
- Dietary Habits and Stomach Cancer Risk in the JACC Study
- Frequency of Food Intake and Estimated Nutrient Intake among Men and Women : The JACC Study
- Impact of Smoking and Other Lifestyle Factors on Life Expectancy among Japanese: Findings from the Japan Collaborative Cohort (JACC) Study
- Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese
- Meat, milk, saturated fatty acids, the Pro12Ala and C161T polymorphisms of the PPARγ gene and colorectal cancer risk in Japanese
- A polymorphism of C-to-T substitution at -31 IL1B is associated with the risk of advanced gastric adenocarcinoma in a Japanese population
- Dietary Risk Factors for Colon and Rectal Cancers : A Comparative Case-Control Study
- Effect of dietary antioxidants and risk of oral, pharyngeal and laryngeal squamous cell carcinoma according to smoking and drinking habits
- Significant association of interleukin 8-251T/A polymorphism with smoking behavior in a Japanese population
- Association between genetic polymorphisms of the base excision repair gene MUTYH and increased colorectal cancer risk in a Japanese population
- Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer : The Fukuoka Colorectal Cancer Study
- Physical activity and colorectal cancer : The Fukuoka Colorectal Cancer Study
- Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorectal cancer : The Fukuoka Colorectal Cancer Study
- Serum Pepsinogen Values and Helicobacter pylori Status among Control Subjects of a Nested Case-Control Study in the JACC study
- Serum Levels of Insulin-like Growth Factor I, II, and Binding Protein 3, Transforming Growth Factor β-1, Soluble Fas Ligand and Superoxide Dismutase Activity in Stomach Cancer Cases and Their Controls in the JACC Study
- Cigarette Smoking and Mortality due to Stomach Cancer : Findings from the JACC Study
- Green Tea and Stomach Cancer : A Short Review of Prospective Studies
- Mortality and Incidence Rates of Stomach Cancer in the JACC Study
- Epidemiology of X-linked adrenoleukodystrophy in Japan
- Diabetes mellitus and kidney cancer risk : The results of Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study)
- Alcohol Consumption and Lung Cancer Mortality in Japanese Men : Results from Japan Collaborative Cohort (JACC) Study
- Association of Serum Carotenoid Concentration and Dietary Habits among the JACC Study Subjects
- Risk Factors for Kidney Cancer in a Japanese Population : Findings from the JACC Study
- Dietary Habits and Risk of Urothelial Cancer Incidence in the JACC Study
- Colorectal Cancer and Serum C-reactive Protein Levels : a Case-control Study Nested in the JACC Study
- Glucose Intolerance and Colorectal Cancer Risk in a Nested Case-Control Study among Japanese People
- Alcohol Consumption and Colorectal Cancer Risk : Findings from the JACC Study
- Medical History of Circulatory Diseases and Colorectal Cancer Death in the JACC Study
- Lung Cancer Mortality and Serum Levels of Carotenoids, Retinol, Tocopherols, and Folic Acid in Men and Women : a Case-Control Study Nested in the JACC Study
- Updated Information on Risk Factors for Lung Cancer : Findings from the JACC Study
- Preface
- Stability of Frozen Serum Levels of Insulin-like Growth Factor-I, Insulin-like Growth Factor-II, Insulin-like Growth Factor Binding Protein-3, Transforming Growth Factorβ, Soluble Fas, and Superoxide Dismutase Activity for the JACC Study
- A Prospective Cohort Study of Perceived Noise Exposure at Work and Cerebrovascular Diseases among Male Workers in Japan
- Levels of Physical Activity among Participants in the JACC Study
- Epidemiologic and Clinical Characteristics of Cardiomyopathies in Japan : Results From Nationwide Surveys
- Dietary Habits and Risk of Lung Cancer Death in a Large-scale Cohort Study (JACC Study) in Japan by Sex and Smoking Habit
- Decrease in Risk of Lung Cancer Death in Males after Smoking Cessation by Age at Quitting : Findings from the JACC Study
- Tea Consumption and Lung Cancer Risk : A Case-Control Study in Okinawa, Japan
- Serum carotenoids and mortality from lung cancer : a case-control study nested in the Japan Collaborative Cohort (JACC) Study
- Associations of Lifestyle Factors with Bone Mineral Density among Male University Students in Japan
- The Relationship between Smoking Habits and Serum Levels of 8-OHdG, Oxidized LDL Antibodies, Mn-SOD and Carotenoids in Rural Japanese Residents
- Depressive Mood and Suicide Among Middle-Aged Workers : Findings from a Prospective Cohort Study in Nagoya, Japan
- Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese
- Clinical Usefulness of Oral Combination Chemotherapy of 5'-Deoxy-5-Fluorouridine (5'-DFUR) and Cyclophosphamide for Metastatic Breast Cancer
- Immunohistochemical Evaluation of Hormone Receptor Status for Predicting Response to Endocrine Therapy in Metastatic Breast Cancer
- Comparison of Five Different Antibodies in the Immunohistochmical Assay of Estrogen Receptor α in Human Breast Cancer
- Expression of Estrogen Receptor α Exon 5 and 7 Deletion Variant in Human Breast Cancers
- Baseline data of Shizuoka area in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study)
- CONTROLS FOR MONITORING THE DETERIORATION OF STORED BLOOD SAMPLES IN THE JAPAN MULTI-INSTITUTIONAL COLLABORATIVE COHORT STUDY (J-MICC STUDY)
- Association between Smoking Habits and Tryptophan Hydroxylase Gene C218A Polymorphism among the Japanese Population
- Active Smoking, Passive Smoking, and Breast Cancer Risk : Findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk
- Dietary intakes of fat and fatty acids and risk of breast cancer : A prospective study in Japan
- Cigarette smoking and the risk of ovarian cancer in the Japanese population : Findings from the Japanese Collaborate Cohort study
- Smoking and Drinking Habits Five Years after Baseline in the JACC Study
- Change in Food Intake Frequency at Five Years after Baseline in the JACC Study
- Impact of menstrual and reproductive factors on breast cancer risk in Japan : Results of the JACC study
- A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women : Findings from the JACC study
- A prospective study on the possible association between having children and colon cancer risk : Findings from the JACC Study
- Smoking and Colorectal Cancer in a Non-Western Population : a Prospective Cohort Study in Japan
- Estimated Number of Patients with Chronic Renal Failure but not with End-Stage Renal Disease in Japan : Comparisons Between Two Estimation Methods
- Association of menstrual and reproductive factors with pancreatic cancer risk in women : findings of the Japan Collaborative Cohort Study for Evaluation of Cancer Risk
- Relationships of Age at Menarche and Menopause, and Reproductive Year with Mortality from Cardiovascular Disease in Japanese Postmenopausal Women : The JACC Study
- Overview of the Epidemiology of Pancreatic Cancer Focusing on the JACC Study
- Overview of Epidemiology of Bile Duct and Gallbladder Cancer Focusing on the JACC Study
- Profile of the JACC Study
- Preface
- Validity and Reliability of Single-item Questions about Physical Activity
- Estimated Prevalence and Incidence of Adult Still's Disease : Findings by a Nationwide Epidemiological Survey in Japan
- Case-Control Study of Oral Cancer in Shenyang, Northeastern China
- Survey for Incidence of Cancer as a Measure of Outcome in the JACC Study
- Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men
- Nutritional factors and risk of pancreatic cancer : a population-based case-control study based on direct interview in Japan
- Cigarette Smoking as a Risk Factor for Chronic Pancreatitis : A Case-Control Study in Japan
- Nationwide epidemiological survey of chronic pancreatitis in Japan
- Comparison of Accelerometry and Oxymetry for Measuring Daily Physical Activity
- Sleep Patterns and Total Mortality : A 12-Year Follow-up Study in Japan
- Newly Developed Diabetic Retinopathy and Its Preceding Changes in Biological Markers
- Estimated Prevalence of Sjogren's Syndrome in Japan : Findings from a Nationwide Epidemiological Survey
- Young Epidemiologists' Attitude towards Personal Data Protection
- Mortality in the JACC Study till 1999
- Rationale, Design, and Profiles of the New Integrated Suburban Seniority Investigation (NISSIN) Project : A Study of an Age-Specific, Community-Based Cohort of Japanese Elderly
- Written Informed Consent for Participation in a Study and Reduction in Consent Rate
- Smoking, Alcohol Drinking and Esophageal Cancer : Findings from the JACC Study
- Serum Insulin-like Growth Factors, Insulin-like Growth Factor-biding Protein-3, and Risk of Lung Cancer Death : A Case-control Study Nested in the Japan Collaborative Cohort (JACC) Study
- Population Attributable Fraction of Mortality Associated with Tobacco Smoking in Japan : A Pooled Analysis of Three Large-scale Cohort Studies
- Smoking Habits, Local Brand Cigarettes and Lung Cancer Risk in Okinawa, Japan
- Maternal Active and Passive Smoking and Fetal Growth : A Prospective Study in Nagoya, Japan
- Prevalence of Idiopathic Hypoparathyroidism and Pseudohypoparathyroidism in Japan
- A Simple Food Frequency Questionnaire for Japanese Diet : Part II. Reproducibility and Validity for Nutrient Intakes
- A Simple Food Frequency Questionnaire for Japanese Diet : Part I. Development of the Questionnaire, and Reproducibility and Validity for Food Groups
- Descriptive Epidemiology of Pancreatic Cancer in Japan
- Factors Influencing an Ultrasound-Estimated Bone Mass in Postmenopausal Women
- RELATION OF FALLS EFFICACY SCALE (FES) TO QUALITY OF LIFE AMONG NURSING HOME FEMALE RESIDENTS WITH COMPARATIVELY INTACT COGNITIVE FUNCTION IN JAPAN
- Informed Consent in Epidemiologic Research before the Implementation of Ethical Guidelines
- Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study)
- Agreement Between Self- and Partner Reports Obtained by a Self-Administered Questionnaire : Medical and Lifestyle Information
- Impact of Smoking and Other Lifestyle Factors on Life Expectancy among Japanese : Findings from the Japan Collaborative Cohort (JACC) Study
- Associations of Lifestyle Factors with Bone Mineral Density among Male University Students in Japan
- Incidence and prevalence of inflammatory bowel disease in Japan: Nationwide epidemiological survey during the year 1991