Lung Cancer Mortality and Serum Levels of Carotenoids, Retinol, Tocopherols, and Folic Acid in Men and Women : a Case-Control Study Nested in the JACC Study

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概要

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• BACKGROUND: Lung cancer mortality is inversely associated with high serum carotenoid levels and high intake of vegetables and fruits rich in carotenoids. The Japan Collaborative Cohort (JACC) Study was conducted to investigate whether serum levels of carotenoids, retinol, tocopherols, and folic acid were associated with risk for lung cancer death with follow-up through 1997. To examine the association by sex, we extended the follow-up and analyzed additional serum samples.METHODS: In the JACC Study, 39,242 subjects provided serum samples at baseline between 1988 and 1990. We identified 211 cases (163 men and 48 women) of death from lung cancer during about 10-year follow-up ending in 1999. Of the subjects who survived to the end of that follow-up, 487 controls (375 men and 112 women) were selected, and were matched to each case of lung cancer death for sex, age and participating institution. We measured serum levels of antioxidants in cases of lung cancer death and controls. Odds ratio (OR) for lung cancer death was estimated using conditional logistic models by sex.RESULTS: For men, the risk of lung cancer death was significantly lower for the highest quartile of serum α- and β-carotenes, lycopene, and β-cryptoxanthin than for the lowest quartile: the OR adjusted for smoking and other covariates were 0.41, 0.28, 0.46, and 0.39, respectively. For women, serum levels of α-carotene and zeaxanthin/lutein were inversely associated with risk of lung cancer, but the association was not significant. No association between lung cancer and serum levels of β-carotene, β-cryptoxanthin, and retinol was appeared among women. There was a suggestion that association between lung cancer and high serum levels of these components might differ between men and women.CONCLUSIONS: Higher serum levels of carotenoids appear to play a role in preventing death from lung cancer among Japanese men. Relationships between lung cancer and serum levels of some carotenoids appear to differ between sexes. However, further study with a large number of women cases needs to clarify the discrepancy between sexes.J Epidemiol 2005; 15: S140-S149.

• 日本疫学会の論文
• 2005-06-01

著者

• OZASA Kotaro

  Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medici

• WATANABE Yoshiyuki

  Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medici

• ITO Yoshinori

  Department of Public Health, Fujita Health University School of Health Sciences

• SUZUKI Koji

  Department of Public Health, Fujita Health University School of Health Sciences

• TAMAKOSHI Akiko

  Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Gradu

• Ito Yoshinori

  Department Of Public Health Fujita Health University School Of Health Sciences

• Ito Yoshinori

  札幌医科大学 医学部公衆衛生学

• KONDO Takaaki

  Department of Medical Technology, Nagoya University School of Health Sciences

• Nakamura Y

  Department Of Public Health Jichi Medical University

• Kondo Takaaki

  Department Of Cardiology Nagoya University Graduate School Of Medicine

• Wakai K

  Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua

• Wakai Kenji

  愛知県がんセンター研究所 疫学予防部

• NISHINO Yoshikazu

  Division of Epidemiology, Miyagi Cancer Center Research Institute

• Ito Yoshinori

  Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua

• WAKAI Kenji

  Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute

• Nakamura Yosikazu

  千代田区千代田保健所

• Nishino Yoshikazu

  Division Of Epidemiology Miyagi Cancer Center Research Institute

• INABA Yutaka

  Juntendo University School of Medicine

• Inaba Yutaka

  愛知医科大学 公衆衛生学

• ANDO Masahiko

  Kyoto University Center for Student Health

• SEKI Nao

  Department of Infectious Disease Control and International Medicine, Niigata University Graduate Sch

• OHNO Yoshiyuki

  Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Gradu

• Tamakoshi Akiko

  京都府立医科大学 地域保健医療疫学

• Tamakoshi Akiko

  Department Of Epidemiology National Institute For Longevity Sciences

• Suzuki K

  Department Of Public Health School Of Health Sciences Fujita Health University

• Seki N

  Division Of Public Health Department Of Infectious Disease Control And International Medicine Niigat

• Seki Nao

  School Of Health Sciences Fac. Of Medicine Niigata Univ.

• Seki Nao

  新潟大学 医歯学総合研究科

• Ozasa K

  Department Of Epidemiology For Community Health And Medicine Kyoto Prefectural University Of Medicin

• Ozasa Kotaro

  京都府立医科大学 保健･予防医学教室

• Ozasa Kotaro

  Department Of Social Medicine And Cultural Sciences Research Institute For Neurological Diseases And

• Ohno Y

  Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua

• Ohno Yoshiyuki

  名古屋大学 医学系研究科予防医学

• Ando Masahiko

  宮城県立がんセンター研究所 疫学部

• Ando Masahiko

  Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua

• Watanabe Y

  Kyoto Prefectural Univ. Medicine Kyoto Jpn

• Seki Nao

  Division Of Public Health Department Of Infectious Disease Control And International Medicine Niigat

• Obata Yuki

  愛知医科大学 公衆衛生学

• Obata Yuki

  Department Of Public Health Aichi Medical University School Of Medicine

• Ozasa K

  京都府立医科大学 保健･予防医学教室

• Ozasa Kotaro

  Department Of Epidemiology For Community Health And Medicine Kyoto Prefectural University Of Medicin

• Ando M

  Kyoto University Health Service

• Inaba Y

  Department Of Physics University Of Tokyo

• Wakai Kenji

  Division Of Epidemiology And Prevention Aichi Cancer Center Research Institution

• Nakamura Yosikazu

  Department Of Health Science Division Of Epidemiology And Community Health Jichi Medical School

• Tamakoshi Akiko

  Department Of Clinical Trials National Center For Geriatrics And Gerontology

• Wada Yasuhiro

  Department Of Hygiene Akita University School Of Medicine

• Suzuki Koji

  Department Of Public Health Fujita Health University Of Health Sciences

• Okada Koichi

  Department Of Urology Kyoto Prefectural University Of Medicine

• Ito Yoshinori

  Department Of Medical Oncology Cancer Institute Hospital Japanese Foundation For Cancer Research

• Inaba Y

  Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine

• Nakamura Yosikazu

  Division Of Epidemiology Miyagi Cancer Center Research Institute

• Ogawa Keiko

  Department Of Public Health Tohoku University Graduate School Of Medicine

• Ohno Yoshiyuki

  Department Of Pharmacy The University Of Tokyo Hospital Faculty Of Medicine The University Of Tokyo

• Okamura Kikuo

  National Center For Geriatrics And Gerontology Division Of Urology Department Of Surgery And Intensi

• Watanabe Yoshiyuki

  Department Of Biotechnology And Chemistry School Of Engineering Kinki University

• Niwa Yoshimitsu

  自治医科大学 公衆衛生学

• Wakai Kenji

  Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua

• Ito Yoshinori

  Department Of Biomedical Food Research National Institute Of Infectious Diseasea(former National Ins

• Ohno Yoshiyuki

  Department Of Pharmacy Kinjogakuin University

• Watanabe Yoshiyuki

  Department Of Epidemiology For Community Health And Medicine Kyoto Prefectural University Of Medicin

• Suzuki Koji

  Department Of Applied Chemistry Faculty Of Science And Technology Keio University

• Ito Yoshinori

  Department Of Biochemistry Nagoya City University Medical School

• Suzuki Koji

  Department Of Orthopaedic Surgery Toride Kyodo General Hospital

• Nishino Yoshikazu

  Division Of Epidemiology Department Of Public Health And Forensic Medicine Tohoku University Graduate School Of Medicine

• SUZUKI Koji

  Department of Agricultural Chemistry, University of the Ryukyus

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