Impairment State of Cognitive Performance and the Affecting Factors in Outpatients Following Gastrointestinal Endoscopy after Single-dose Diazepam
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概要
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Diazepam is commonly used as premedicant for endoscopic procedures. Wide interindividual differences have been observed in the residual cognitive effects of the drug after gastrointestinal endoscopy. Our aim was to clarify the major factors, including pharmacokinetic factors, contributing to this wide variation in residual cognitive effect after gastrointestinal endoscopy in the study. Sixty-one outpatients undergoing gastrointestinal endoscopy participated in the study. Cognitive effects were evaluated in the diazepam group (n=52) by the digit symbol substitution test (DSST) twice before and 30 min after an intravenous administration of 5 mg diazepam; in the intervening time gastrointestinal endoscopy was performed. Plasma concentrations of diazepam were determined by HPLC. The control group (n=9) was tested by DSST in the same manner. The cognitive effects according to the change in DSST score was significantly decline in the diazepam group compared with the control group (by 0.2 versus -4.6; P=0.014). This prospective study confirmed that cognition was significantly impaired after gastrointestinal endoscopy by premedication to subjects with 5 mg diazepam. There were very wide variations in change in DSST score. However we could not identify the independent variables that best predicted DSST score difference in a multiple regression analysis for age, plasma albumin level, and plasma diazepam concentration 30 min after intravenous administration. We should pay attention to patients' individual states in cognitive performance following gastrointestinal endoscopy after single-dose diazepam.
- 公益社団法人日本薬学会の論文
- 2005-03-01
著者
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WATANABE Yoshiyuki
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medici
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増原 慶壮
Department Of Pharmacy St. Marianna University School Of Medicine Hospital
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ITOH Fumio
Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna Universit
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浅見 妥江
Department Of Pharmacy St. Marianna University School Of Medicine Hospital
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Masuhara Keisou
Department of Pharmacy, St. Marianna University School of Medicine Hospital
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Masuhara Keisou
Department Of Pharmacy. St. Marianna University School Of Medicine Hospital
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Itoh Fumio
Department Of Gastroenterology And Hepatology St. Marianna Medical University School Of Medicine
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緒方 宏泰
Course Of Clinical Pharmacy Graduate School Of Pharmaceutical Sciences Meiji Pharmaceutical Universi
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Ogata Hiroyasu
Course Of Clinical Pharmacy. Graduate School Of Pharmaceutical Sciences:department Of Biopharmaceuti
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NAKAZONO Kenichi
Course of Clinical Pharmacy. Graduate School of Pharmaceutical Sciences
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NAKAYA Shinichi
Department of Gastroenterology and Hepatology. St. Marianna University School of Medicine
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ASAMI Yoshie
Department of Pharmacy. St. Marianna University School of Medicine Hospital
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Itoh Fumio
Department Of Gastroenterology And Hepatology. St. Marianna University School Of Medicine
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Watanabe Yoshiyuki
Department Of Biotechnology And Chemistry School Of Engineering Kinki University
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Watanabe Yoshiyuki
Department Of Gastroenterology And Hepatology. St. Marianna University School Of Medicine
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中薗 健一
Course of Clinical Pharmacy. Graduate School of Pharmaceutical Sciences
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渡邊 嘉行
Department of Gastroenterology and Hepatology. St. Marianna University School of Medicine
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中谷 信一
Department of Gastroenterology and Hepatology. St. Marianna University School of Medicine
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伊東 文生
Department of Gastroenterology and Hepatology. St. Marianna University School of Medicine
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