Cardiovascular Disease Mortality and Serum Carotenoid Levels : a Japanese Population-based Follow-up Study
スポンサーリンク
概要
- 論文の詳細を見る
BACKGROUND: Some observational epidemiologic studies suggest that dietary and serum carotenoids are associated with reduced cardiovascular disease mortality.METHODS: Three thousand and sixty-one subjects (1,190 males and 1,871 females), aged 39 to 80 years, were recruited from residents of Hokkaido, Japan who had attended comprehensive health check-up programs from 1988 through 1995. Serum levels of α-carotene, β-carotene, and lycopene were separately determined by high-performance liquid chromatography. Serum levels of total carotene consisted of the sum of α-carotene, β-carotene, and lycopene levels. Each serum level of α-carotene, β-carotene, lycopene, total carotene, triglyceride, and alanine transaminase (ALT) activity was transformed logarithmically. The hazard ratios of serum α- and β-carotenes, lycopene, and total carotene values were estimated by the Cox proportional hazard model after adjusting for sex, age, and other potential confounding factors.RESULTS: During the 11.9-year follow-up period, 80 deaths (49 males and 31 females) from cardiovascular disease, 40 deaths from heart disease, and 37 deaths from stroke were identified among the cohort subjects. High serum values of carotenoids such as α- and β-carotenes, and lycopene were found to be significantly associated with low hazard ratios for cardiovascular disease mortality. However, a significant inverse association between high serum lycopene value and the risk for stroke mortality was not always observed.CONCLUSIONS: High serum levels of total carotene, comprising α- and β-carotenes and lycopene, may reduce the risk for cardiovascular disease mortality among the Japanese population.J Epidemiol 2006; 16: 154-160.
- 日本疫学会の論文
- 2006-07-01
著者
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ITO Yoshinori
Department of Public Health, Fujita Health University School of Health Sciences
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SUZUKI Koji
Department of Public Health, Fujita Health University School of Health Sciences
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Ito Yoshinori
Department Of Public Health Fujita Health University School Of Health Sciences
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Ito Yoshinori
札幌医科大学 医学部公衆衛生学
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Hishida Hitoshi
Department Of Internal Medicine Fujita Health University School Of Medicine
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Ito Yoshinori
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
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HAMAJIMA Nobuyuki
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Gradu
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INABA Yutaka
Juntendo University School of Medicine
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Hatsumi Naoko
Japan Adult Leukemia Study Group Hamamatsu Jpn
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Inaba Yutaka
愛知医科大学 公衆衛生学
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KURATA Mio
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Gradu
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AOKI Kunio
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Gradu
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Suzuki K
Department Of Public Health School Of Health Sciences Fujita Health University
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Hamajima N
Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua
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Hamajima Nobuyuki
愛知県がんセンター研究所 疫学・予防部
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Hamajima Nobuyuki
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
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Inaba Y
Juntendo Univ. School Of Medicine
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Ishida Yoshiko
Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua
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Aoki Kunio
Department Of Health And Environmental Sciences Kyoto University Graduate School Of Medicine
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Hamajima Nobuyuki
Department Of Preventive Medicine Aichi Cancer Center Research Institute
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Hamajima Nobuyuki
Cancer Information Service And Surveillance Division Cancer For Cancer Control And Information Servi
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Hamajima Nobuyuki
Department Of Preventive Medicine
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Inaba Y
Department Of Physics University Of Tokyo
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Nakagawa H
Department Of Public Health Kanazawa Medical University
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Suzuki Koji
Department Of Public Health Fujita Health University Of Health Sciences
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Ito Yoshinori
Department Of Medical Oncology Cancer Institute Hospital Japanese Foundation For Cancer Research
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Inaba Y
Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine
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Hoki Noriyuki
Department Of Gastroenterology Aichi Cancer Center Hospital
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Hamajima N
Department Of Preventive Medicine Biostatistics And Medical Decision Making Nagoya University Gradua
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Aoki Kunio
Program In Radiological And Medical Laboratory Sciences Nagoya University Graduate School Of Medicin
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Kurata Mio
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
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Aoki Kunio
Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University
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Kimura Asami
Dep. Of Public Health School Of Health Sciences Fujita Health Univ.
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Inaba Yutaka
Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University
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Ito Yoshinori
Department Of Biomedical Food Research National Institute Of Infectious Diseasea(former National Ins
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Ito Yoshinori
Department Of Preventive Medicine - Biostatistics And Medical Decision Making Nagoya University Grad
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Hatsumi Naoko
Leukemia Research Center Saiseikai Maebashi Hospital
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Suzuki Koji
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Ito Yoshinori
Department Of Biochemistry Nagoya City University Medical School
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Ito Yoshinori
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
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Inoue Yusuke
Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University
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Suzuki Koji
Department Of Orthopaedic Surgery Toride Kyodo General Hospital
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Hishida Hitoshi
Department Of Cardiology Fujita Health University School Of Medicine
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Hamajima Nobuyuki
Department of Epidemiology and Public Health, Kanazawa Medical University
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INABA Yutaka
Department of Physics, University of Tokyo
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SUZUKI Koji
Department of Agricultural Chemistry, University of the Ryukyus
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AOKI Kunio
Department of Engineering, National Science Museum
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