Association between Interleukin-1B C-31T Polymorphism and Obesity in Japanese
スポンサーリンク
概要
- 論文の詳細を見る
Background: Recent studies have revealed a close relationship between obesity and polymorphism in the inflammation gene. However, the association between interleukin-1beta (IL-1β) and obesity remains controversial. We therefore investigated the association between IL-1B C-31T polymorphism and obesity in Japanese.Methods: The participants were 802 inhabitants (281 men and 521 women) of Japan, aged 39 to 88 years, who attended a health examination in 2003. Body height, weight, waist and hip circumferences, and body fat percentage were measured. The IL-1B C-31T polymorphism was genotyped by polymerase chain reaction with confronting 2-pair primers. The association between IL-1B C-31T genotypes and various indices of obesity was then investigated. The confounding factor-adjusted odds ratios (OR) and 95% confidence intervals (CI) for obesity were calculated for each IL-1B C-31T genotype by using unconditional logistic regression analysis.Results: Among male carriers of the CT and TT genotypes, the ORs for high body fat percentage were 2.58 (95% CI, 1.17–6.34) and 2.81 (1.17–7.33), respectively, as compared to carriers of the CC genotype (P for trend = 0.037). Among women, carriers of the TT genotype had significantly higher ORs for high BMI (OR, 2.13; 95% CI, 1.25–3.67) and large waist circumference (2.49; 1.37–4.66), as compared to women with the CC genotype (P for trend = 0.005 and 0.004, respectively).Conclusions: The IL-1B C-31T polymorphism is associated with obesity in Japanese. Men and women with the TT genotype of IL-1B C-31T had a higher risk for obesity than those with the CC genotype.
- 日本疫学会の論文
- 2009-05-01
著者
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INOUE Takashi
Department of Neurosurgery, School of Medicine, Iwate Medical University
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ITO Yoshinori
Department of Public Health, Fujita Health University School of Health Sciences
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SUZUKI Koji
Department of Public Health, Fujita Health University School of Health Sciences
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Ito Yoshinori
Department Of Public Health Fujita Health University School Of Health Sciences
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Ito Yoshinori
札幌医科大学 医学部公衆衛生学
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Ito Yoshinori
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
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HAMAJIMA Nobuyuki
Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Gradu
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INABA Yutaka
Juntendo University School of Medicine
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Nakagawa Hideaki
金沢医科大学 健康増進予防医学
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Hatsumi Naoko
Japan Adult Leukemia Study Group Hamamatsu Jpn
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Inaba Yutaka
愛知医科大学 公衆衛生学
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YANAGISAWA Atsumi
Department of Public Health, School of Health Sciences, Fujita Health University
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KIMURA Asami
Department of Public Health, School of Health Sciences, Fujita Health University
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Suzuki K
Department Of Public Health School Of Health Sciences Fujita Health University
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Kimura Asami
Department Of Public Health School Of Health Sciences Fujita Health University
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Hamajima N
Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua
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Hamajima Nobuyuki
愛知県がんセンター研究所 疫学・予防部
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Hamajima Nobuyuki
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
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Inaba Y
Juntendo Univ. School Of Medicine
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Ishida Yoshiko
Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua
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Hamajima Nobuyuki
Department Of Preventive Medicine Aichi Cancer Center Research Institute
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Hamajima Nobuyuki
Cancer Information Service And Surveillance Division Cancer For Cancer Control And Information Servi
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Hamajima Nobuyuki
Department Of Preventive Medicine
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Inaba Y
Department Of Physics University Of Tokyo
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Nakagawa H
Department Of Public Health Kanazawa Medical University
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Suzuki Koji
Department Of Public Health Fujita Health University Of Health Sciences
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Ito Yoshinori
Department Of Medical Oncology Cancer Institute Hospital Japanese Foundation For Cancer Research
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Inaba Y
Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine
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Hoki Noriyuki
Department Of Gastroenterology Aichi Cancer Center Hospital
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Hamajima N
Department Of Preventive Medicine Biostatistics And Medical Decision Making Nagoya University Gradua
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Yanagisawa Atsumi
Department Of Public Health School Of Health Sciences Fujita Health University
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Inaba Yutaka
Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University
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Ito Yoshinori
Department Of Biomedical Food Research National Institute Of Infectious Diseasea(former National Ins
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Ito Yoshinori
Department Of Preventive Medicine - Biostatistics And Medical Decision Making Nagoya University Grad
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Hatsumi Naoko
Leukemia Research Center Saiseikai Maebashi Hospital
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Suzuki Koji
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Ito Yoshinori
Department Of Biochemistry Nagoya City University Medical School
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Ito Yoshinori
Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua
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Inoue Yusuke
Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University
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Inoue Takashi
Department Of Neurosurgery Iwate Medical University
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Suzuki Koji
Department Of Orthopaedic Surgery Toride Kyodo General Hospital
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Inoue Takashi
Department Of Public Health School Of Health Sciences Fujita Health University
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Kimura Asami
Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University
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Inoue Takashi
Department Of Agricultural Engineering Faculty Of Agriculture Hokkaido University
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Hamajima Nobuyuki
Department of Epidemiology and Public Health, Kanazawa Medical University
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INOUE Takashi
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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INABA Yutaka
Department of Physics, University of Tokyo
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SUZUKI Koji
Department of Agricultural Chemistry, University of the Ryukyus
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