Association between Interleukin-1B C-31T Polymorphism and Obesity in Japanese

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概要

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• Background: Recent studies have revealed a close relationship between obesity and polymorphism in the inflammation gene. However, the association between interleukin-1beta (IL-1β) and obesity remains controversial. We therefore investigated the association between IL-1B C-31T polymorphism and obesity in Japanese.Methods: The participants were 802 inhabitants (281 men and 521 women) of Japan, aged 39 to 88 years, who attended a health examination in 2003. Body height, weight, waist and hip circumferences, and body fat percentage were measured. The IL-1B C-31T polymorphism was genotyped by polymerase chain reaction with confronting 2-pair primers. The association between IL-1B C-31T genotypes and various indices of obesity was then investigated. The confounding factor-adjusted odds ratios (OR) and 95% confidence intervals (CI) for obesity were calculated for each IL-1B C-31T genotype by using unconditional logistic regression analysis.Results: Among male carriers of the CT and TT genotypes, the ORs for high body fat percentage were 2.58 (95% CI, 1.17–6.34) and 2.81 (1.17–7.33), respectively, as compared to carriers of the CC genotype (P for trend = 0.037). Among women, carriers of the TT genotype had significantly higher ORs for high BMI (OR, 2.13; 95% CI, 1.25–3.67) and large waist circumference (2.49; 1.37–4.66), as compared to women with the CC genotype (P for trend = 0.005 and 0.004, respectively).Conclusions: The IL-1B C-31T polymorphism is associated with obesity in Japanese. Men and women with the TT genotype of IL-1B C-31T had a higher risk for obesity than those with the CC genotype.

• 日本疫学会の論文
• 2009-05-01

著者

• INOUE Takashi

  Department of Neurosurgery, School of Medicine, Iwate Medical University

• ITO Yoshinori

  Department of Public Health, Fujita Health University School of Health Sciences

• SUZUKI Koji

  Department of Public Health, Fujita Health University School of Health Sciences

• Ito Yoshinori

  Department Of Public Health Fujita Health University School Of Health Sciences

• Ito Yoshinori

  札幌医科大学 医学部公衆衛生学

• Ito Yoshinori

  Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua

• HAMAJIMA Nobuyuki

  Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Gradu

• INABA Yutaka

  Juntendo University School of Medicine

• Nakagawa Hideaki

  金沢医科大学 健康増進予防医学

• Hatsumi Naoko

  Japan Adult Leukemia Study Group Hamamatsu Jpn

• Inaba Yutaka

  愛知医科大学 公衆衛生学

• YANAGISAWA Atsumi

  Department of Public Health, School of Health Sciences, Fujita Health University

• KIMURA Asami

  Department of Public Health, School of Health Sciences, Fujita Health University

• Suzuki K

  Department Of Public Health School Of Health Sciences Fujita Health University

• Kimura Asami

  Department Of Public Health School Of Health Sciences Fujita Health University

• Hamajima N

  Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua

• Hamajima Nobuyuki

  愛知県がんセンター研究所 疫学･予防部

• Hamajima Nobuyuki

  Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua

• Inaba Y

  Juntendo Univ. School Of Medicine

• Ishida Yoshiko

  Department Of Preventive Medicine-biostatistics And Medical Decision Making Nagoya University Gradua

• Hamajima Nobuyuki

  Department Of Preventive Medicine Aichi Cancer Center Research Institute

• Hamajima Nobuyuki

  Cancer Information Service And Surveillance Division Cancer For Cancer Control And Information Servi

• Hamajima Nobuyuki

  Department Of Preventive Medicine

• Inaba Y

  Department Of Physics University Of Tokyo

• Nakagawa H

  Department Of Public Health Kanazawa Medical University

• Suzuki Koji

  Department Of Public Health Fujita Health University Of Health Sciences

• Ito Yoshinori

  Department Of Medical Oncology Cancer Institute Hospital Japanese Foundation For Cancer Research

• Inaba Y

  Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine

• Hoki Noriyuki

  Department Of Gastroenterology Aichi Cancer Center Hospital

• Hamajima N

  Department Of Preventive Medicine Biostatistics And Medical Decision Making Nagoya University Gradua

• Yanagisawa Atsumi

  Department Of Public Health School Of Health Sciences Fujita Health University

• Inaba Yutaka

  Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University

• Ito Yoshinori

  Department Of Biomedical Food Research National Institute Of Infectious Diseasea(former National Ins

• Ito Yoshinori

  Department Of Preventive Medicine - Biostatistics And Medical Decision Making Nagoya University Grad

• Hatsumi Naoko

  Leukemia Research Center Saiseikai Maebashi Hospital

• Suzuki Koji

  Department Of Applied Chemistry Faculty Of Science And Technology Keio University

• Ito Yoshinori

  Department Of Biochemistry Nagoya City University Medical School

• Ito Yoshinori

  Department Of Preventive Medicine/biostatistics And Medical Decision Making Nagoya University Gradua

• Inoue Yusuke

  Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University

• Inoue Takashi

  Department Of Neurosurgery Iwate Medical University

• Suzuki Koji

  Department Of Orthopaedic Surgery Toride Kyodo General Hospital

• Inoue Takashi

  Department Of Public Health School Of Health Sciences Fujita Health University

• Kimura Asami

  Department Of Health And Environmental Sciences Graduate School Of Medicine Kyoto University

• Inoue Takashi

  Department Of Agricultural Engineering Faculty Of Agriculture Hokkaido University

• Hamajima Nobuyuki

  Department of Epidemiology and Public Health, Kanazawa Medical University

• INOUE Takashi

  Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo

• INABA Yutaka

  Department of Physics, University of Tokyo

• SUZUKI Koji

  Department of Agricultural Chemistry, University of the Ryukyus

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