Quantitative Assessment of Regional Myocardial Flow Reserve Using Tc-99m-Sestamibi Imaging : Comparison With Results of O-15 Water PET
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概要
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Background The aims of this study were to develop a method for quantitative estimation of the myocardial blood flow index (MBFI) and myocardial flow reserve (MFR) of the whole left ventricle using ^<99m>technetium (Tc-99m)-sestamibi imaging. Methods and Results Twenty-two patients with suspected coronary artery disease and 7 controls underwent both Tc-99m-sestamibi imaging and O-15 water positron emission tomography (PET). The global MBFI was calculated on the basis of the microsphere model from the ratio of the myocardial count to the area under the time-activity curve on the aortic arch. The regional MBFI was calculated from the relative distributions of Tc-99m-sestamibi uptake values. The regional MBFI and MFR (Tc-MFR) obtained using single-photon emission computed tomography were compared with the myocardial blood flow (MBF) and MFR (PET-MFR) obtained using PET as the gold standard. Regional MBFI significantly correlated with the MBF obtained using PET. Regional Tc-MFR also correlated with the regional PET-MFR, with some underestimation. Conclusion These results indicate that regional MBF and MFR may be estimated by dynamic Tc-99m-sestamibi imaging and can be used for the early detection and estimation of the functional severity of coronary lesions without the need for a PET camera.
- 社団法人日本循環器学会の論文
- 2005-01-20
著者
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ITO Yoshinori
Department of Public Health, Fujita Health University School of Health Sciences
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Okamoto Hiroshi
Department Of Cardiovascular Medicine Hokkaido University Hospital
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Tsukamoto Takahiro
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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TAMAKI NAGARA
Nuclear Medicine, Kyoto University Hospital
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Ishida Y
Department Radiology And Nuclear Medicine National Cardiovascular Center
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Onozuka Hisao
北海道大学 医学研究科循環病態内科学
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Morita Koichi
台湾
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Morita Koichi
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Morita K
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Ikeda Yoshihiko
Division Of Pathology National Cardiovascular Center
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Noriyasu Kazuyuki
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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Morita Koichi
Nuclear Medicine, Graduate School of Medicine, Hokkaido University
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Katoh Chietsugu
Nuclear Medicine, Graduate School of Medicine, Hokkaido University
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Nakata Tomoaki
Second Department Of Internal Medicine Sapporo Medicine University
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Itoh Yoshinori
Department of Cardiovascular Medicine, Hokkaido University, Graduate School of Medicine
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Iwadou Yasuyoshi
Departments Of Cardiovascular Medicine Graduate School Of Medicine Hokkaido University
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Tamaki Nagara
Nuclear Medicine Hokkaido University School Of Medicine
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Katoh C
Department Of Health Science Hokkaido University Graduate School Of Medicine
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Tsukamoto Takahiro
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Ito Yoshinori
Department Of Medical Oncology Cancer Institute Hospital Japanese Foundation For Cancer Research
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Morita Ken
Section Of Urology Kushiro City General Hospital
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Katoh Chietsugu
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Okada Hitoshi
Departments Of Cardiovascular Medicine Graduate School Of Medicine Hokkaido University
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Tamaki Nagara
Hokkaido University Nuclear Medicine
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Ito Yoshinori
Department Of Biomedical Food Research National Institute Of Infectious Diseasea(former National Ins
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Okamoto Hiroshi
Department Of Advanced Materials Science Graduate School Of Frontier Sciences University Of Tokyo:cr
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Okamoto Hiroshi
Department Of Advanced Biological Sciences For Regeneration (kotobiken Medical Laboratories) Tohoku
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Okamoto Hiroshi
Departments Of Cardiovascular Medicine Graduate School Of Medicine Hokkaido University
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Ito Yoshinori
Department Of Biochemistry Nagoya City University Medical School
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Noriyasu Kazuyuki
Departments Of Cardiovascular Medicine Graduate School Of Medicine Hokkaido University
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Iwado Yasuyoshi
Department Of Cardiorenal And Cerebrovascular Medicine Kagawa University
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Noriyasu Kazuyuki
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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