Acute and Recurrent Hepatitis Induced by 2, 2-Dichloro-1, 1, 1-trifluoroethane (HCFC-123)
スポンサーリンク
概要
- 論文の詳細を見る
A 49-yr-old female cleaning worker first visited a hospital because of acute hepatitis. On admission, laboratory examination revealed severe hepatic damage (AST 2125 IU/L, ALT 2391 IU/L, LDH 1279 IU/L, t-Bil 8.5 mg/dl), but failed to disclose any evidence of viral infection or morphological lesions. She recovered day by day without any specific treatment for hepatitis and was discharged one month later. On the 11th day after restarting her job, she was readmitted due to similar symptoms and signs. Serum biochemistry data again showed severe liver damage (AST 1354, ALT 1604, LDH 1119 t-Bil 2.6). Histopathological diagnosis based on hepatic needle biopsy was chronic active hepatitis with diffuse infiltration of lymphocyte-dominant inflammatory cells, bridging necrosis, intercellular fibrosis in a limited region, and with ballooning, degeneration, and/or necrosis of the hepatic cells. A job-related cause was suspected and 2, 2-dichloro-1, 1, 1-trifluoroethane (HCFC-123), which has been proven to cause acute hepatitis in humans, was detected in a dry-cleaning solvent by gas chromatography-mass spectrometry analysis. A job simulation experiment suggested that the concentration of the patient's exposure to HCFC-123 exceeded 1, 000 ppm during the busiest work period, which was sufficiently high to induce severe liver damage.
- 社団法人日本産業衛生学会の論文
著者
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Takebayashi T
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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TAKEBAYASHI Toru
Department of Preventive Medicine and Public Health, Keio University School of Medicine
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OMAE Kazuyuki
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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TANAKA Shigeru
Faculty of Hygienic Technology, School of Allied Health Sciences, Kitasato University
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KABE Isamu
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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MIYAUCHI Hiroyuki
The Association of Industrial Health
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SASAKI Keiko
Internal Medicine, Kitami Red Cross Hospital
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TANEICHI Koji
Internal Medicine, Kitami Red Cross Hospital
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SHIBAKI Hidetoshi
Internal Medicine, Kitami Red Cross Hospital
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Omae Kazuyuki
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Omae Kazuyuki
慶応義塾大学 医学部衛生学公衆衛生学
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Omae Kazuyuki
慶應義塾大学医学部衛生学公衆衛生学教室
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Omae Kazuyuki
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Omae Kazuyuki
東京医科歯科大学難治疾患研究所 分子疫学
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Takebayashi Toru
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Oda Kenichi
Department Of Preventive Medicine & Public Health School Of Medicine Keio University
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Hirata Miyuki
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Taneichi Koji
Internal Medicine Kitami Red Cross Hospital
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Takahashi Ken
Japan Industrial Safety And Health Association
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Endo Y
Japan Soc. For Occupational Health
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Yamauchi Tuneyuki
Occupational Health Research And Development Center Japan Industrial Safety And Health Association:j
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Kabe Isamu
Department Of Preventive Medicine And Public Health School Of Medicine Keio University:department Of
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Shibaki Hidetoshi
Internal Medicine Kitami Red Cross Hospital
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Tanaka Shigeru
Department Of Public Health School Of Human Life Sciences Jumonji University
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Sasaki Keiko
Internal Medicine Kitami Red Cross Hospital
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Takebayashi Toru
Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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