Testicular Toxicity Evaluation of Two Antimony Compounds, Antimony Trioxide and Antimony Potassium Tartrate, in Rats and Mice
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概要
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Objectives : Testicular toxicities of antimony compounds were evaluated in rats and mice. The slightly water-soluble antimony compound antimony trioxide (ATO) and the highly water-soluble antimony compound antimony potassium tartrate (APT) were examined. Methods : Daily doses of the compounds were 27.4, 12.0 and 1, 200 mg/kg body weight in the APT group, low-ATO group and high-ATO group, respectively. The corresponding daily doses of antimony were 10, 10 and 1, 000 mg/kg body weight, in the APT group, low-ATO group and high-ATO group, respectively. Both compounds were administered by gavage : rats, 3 days per week for 4 weeks ; mice, 5 days per week for 4 weeks. Results : Neither compound reduced the weights of reproductive organs or accessory sex organs nor affected sperm parameters. Few marked histopathologic changes were found in the testes of the treated animals. Even at 1, 200 mg/kg body weight, which is greater than the LD_<50> of APT, ATO produced no effects. Conclusions : In this study, it was found that ATO and APT are not toxic to testes in rodents.
著者
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Nakano Makiko
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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OMURA Minoru
Department of Hygiene
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Omura M
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Hirata Mari
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Hirata Miyuki
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Hirata Miyuki
Department Of Clinical Labolatory Yamagata University School Of Medicine
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Endo Y
Japan Soc. For Occupational Health
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Inoue Naohide
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Inoue Naohide
Department Of Hygiene Faculty Of Medicine Kyushu University
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Tanaka Akiyo
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
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Omura Minoru
九州大学 医研究院衛生学
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INOUE Naohide
Department of Environmental Toxicology, School of Medicine, University of Occupational and Environmental Health
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