Lack of Relationship between Occupational Exposure to Carbon Disulfide and Endocrine Dysfunction : A Six-year Cohort Study of the Japanese Rayon Workers
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概要
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Lack of Relationship between Occupational Exposure to Carbon Disulfide and Endocrine Dysfunction : A Six-year Cohort Study of the Japanese Rayon Workers : Toru TAKEBAYASHI, et al. Department of Preventive Medicine and Public Health, School of Medicine, Keio University-Objectives-A six-year prospective cohort study was conducted to clarify whether the current carbon disulfide (CS_2) exposure level is low enough to prevent subclinical health impairment and/or to ameliorate health effects due to previous high exposure. This paper describes the follow-up results, exposure assessment, and effects on the endocrine system. Methods-The study subjects were 432 male workers exposed to CS_2 at one of the 11 rayon factories in Japan and 402 referent workers from the same factories, all of whom were examined in 1992-93. 251 CS_2-exposed, 140 former-exposed and 359 referent workers participated in the follow-up survey (follow-up rate 89.9%) in 1998-99. Urinary 2-thiothiazolidine-4-carboxylic acid (TTCA) at the end of a shift as internal exposure index and the time-weighted average CS_2 concentration as external exposure index were measured twice a year from 1992-1993. By using various blood indices, we evaluated effects on thyroid, hypophysis, and gonad function, as well as effects on glucose metabolism. Information on potential confounding factors, such as age, smoking and alcohol drinking, were collected and adjusted for. Results-When the individual exposure level was represented by arithmetic mean for TTCA and CS_2 concentration, geometric means (SD) of CS_2 workers were 1.61 (1.91) mg/g. crea and 5.02 (1.84) ppm, respectively. There were no exposure-related differences in glucose metabolism or any of the endocrinological indices. Conclusions-No biologically significant effects of CS_2 were found on endocrine function in Japanese rayon manufacturing workers when the average internal and external exposure levels were maintained below the current occupational exposure limit. (J Occup Health 2003 ; 45 : 111-118)
- 社団法人日本産業衛生学会の論文
著者
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上村 隆元
杏林大学 医学部 衛生学公衆衛生学教室
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Takebayashi T
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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NISHIWAKI Yuji
Department of Preventive Medicine and Public Health, Keio University School of Medicine
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TAKEBAYASHI Toru
Department of Preventive Medicine and Public Health, Keio University School of Medicine
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UEMURA Takamoto
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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OMAE Kazuyuki
Department of Preventive Medicine and Public Health, School of Medicine, Keio University
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NOMIYAMA Tetsuo
Department of Preventive Medicine and Public Health,School of Medicine,Keio University
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YAMAUCHI Tsuneyuki
Occupational Health Research and Development Center,Japan Industrial Safety and Health Association
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TANAKA Shigeru
Human Environmental Science,Jumonji University
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SAKURAI Haruhiko
Department of Preventive Medicine and Public Health,School of Medicine,Keio University
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SAKURAI Haruhiko
Occupational Health Research and Development Center, Japan Industrial Safety and Health Association
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Omae Kazuyuki
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Omae Kazuyuki
慶応義塾大学 医学部衛生学公衆衛生学
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Omae Kazuyuki
慶應義塾大学医学部衛生学公衆衛生学教室
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Omae Kazuyuki
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Omae Kazuyuki
東京医科歯科大学難治疾患研究所 分子疫学
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Nakano Makiko
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Nomiyama T
Division Of Environmental Medicine Department Of Preventive Medicine School Of Medicine Shinshu Univ
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Nomiyama Tetsuo
Department Of Preventive Medicine Shinshu University School Of Medicine
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Takahashi Ken
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Takebayashi Toru
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Oda Kenichi
Department Of Preventive Medicine & Public Health School Of Medicine Keio University
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Hirata Miyuki
Department Of Hygiene Graduate School Of Medical Sciences Kyushu University
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Takahashi Ken
Japan Industrial Safety And Health Association
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Endo Y
Japan Soc. For Occupational Health
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Sakurai H
Showa Univ. Tokyo Jpn
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Sakurai Haruhiko
Occupational Health Research And Development Center Japan Industrial Health Association
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Sakurai Haruhiko
Department Of Cardiology Toki General Hospital
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Nishiwaki Yuji
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Nishiwaki Yuji
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
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Nishiwaki Yuji
Department Of Preventive Medicine And Public Health Keio University
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Uemura Takamoto
Department Of Preventive Medicine And Public Health School Of Medicine Keio University
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Tanaka Akiyo
Department Of Environmental Medicine Graduate School Of Medical Sciences Kyushu University
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Yamauchi Tuneyuki
Occupational Health Research And Development Center Japan Industrial Safety And Health Association:j
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Tanaka Shigeru
Department Of Public Health School Of Human Life Sciences Jumonji University
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Yamauchi Tsuneyuki
Occupational Health Research And Development Center Japan Industrial Safety And Health Association
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Omae K
慶應義塾大学医学部衛生学公衆衛生学教室
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NISHIWAKI Yuji
Department of Environmental and Occupational Health, Faculty of Medicine, Toho University
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Nishiwaki Yuji
Department of Environmental and Occupational Health, School of Medicine, Toho University
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Takebayashi Toru
Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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NOMIYAMA Tetsuo
Department of Preventive Medicine and Public Health, Shinshu University School of Medicine
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