Uptake of Cadmium in Meals from the Digestive Tract of Young Non-smoking Japanese Female Volunteers

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Objectives-To estimate rates of cadmium (Cd) uptake from the digestive tract and changes in Cd in biological specimens after intake of Cd mainly in rice. Methods- Twenty-f ive young non-smoking Japanese female volunteers (20-23 in age) were recruited and a 20-d experimental study was conducted. With polished rice containing 0.004 ppm and 0.340 ppm of Cd, Meal L and Meal H were prepared. Approximately 12% of total Cd in Meal L and 92% of total Cd in Meal H originated in rice. The volunteers ate Meal L for 11 d to achieve a stable intake-output balance of Cd. Fifteen of the 25 volunteers ate Meal H on the 12^th day (Group D1), and the remaining 10 ate Meal H on the 12^th, 13^th and 14^th day (Group D3). All 25 subjects then resumed the consumption of Meal L to the end of the study (20^th day). All meals, feces and urine were collected during the study, and Cd intake from the daily meals (Cd-I), Cd in feces (Cd-F) and Cd in urine (Cd-U) were determined. For measurement of Cd in blood (Cd-B), venous blood was collected from all volunteers on the day before the study and again on the 12th and 20^th day; venous blood was also collected from 4-8 volunteers at additional time points. Results-Mean Cd-I was 4.51 μg/d (range: 1.85-6.93) or 48.48μg/d (range: 27.98-56.27) when they ate Meal L or Meal H. Cd-F and Cd-B exhibited faster responses to the change in Cd-I than did Cd-U. The Cd_uptake rate, defined as (1-Cd-F_excess /Cd-I_excess) (Fig. 1), was 47.2% (range: -9.4-83.3%) in Group D1 and 36.6% (range: -9.2- 73.5%) in Group D3, andμ the Cd_balance rate, defined as (1-Cd-F_output/Cd-I _intake), was 23.9% (range: -4.0-37.7%) in Group D1 and 23.7% (range: -8.2-56.9%) in Group D3. Conclusions - Cd-F and Cd-B are better biological monitoring parameters for assessing change in Cd-I than Cd-U. The Cd_uptake and Cd_balance rates appeared to be higher than those in previous papers when ingested Cd mainly originated in rice.
社団法人日本産業衛生学会の論文

Uptake of Cadmium in Meals from the Digestive Tract of Young Non-smoking Japanese Female Volunteers

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