Association of Lipoprotein-associated Phospholipase A2 with Coronary Calcification among American and Japanese Men

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概要

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• BACKGROUND: We have previously reported that the prevalence of coronary artery calcification (CAC) was substantially lower among Japanese than American men despite a less favorable profile of many traditional risk factors in Japanese men. To determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are related to the difference in the prevalence of CAC between the two populations.METHODS: A total of 200 men aged 40-49 years were examined: 100 residents in Allegheny County, Pennsylvania, United States, and 100 residents in Kusatsu City, Shiga, Japan. Coronary calcium score (CCS) was evaluated by electron-beam tomography, Lp-PLA2 levels, nuclear magnetic resonance (NMR) lipoprotein subclasses, and other factors were assessed in 2001-2002.RESULTS: Lp-PLA2 levels were higher among American than Japanese men (Mean ± standard deviation 301.7 ± 82.6 versus 275.9 ± 104.7 ng/mL, respectively, p=0.06). Among all Japanese men and those with low density lipoprotein (LDL) cholesterol ≥130 mg/dL, there was an inverse association of the prevalence of CCS>0 with the tertile groups of Lp-PLA2 levels (p=0.08 and p=0.03, respectively). American men did not have any association between CCS>0 with the tertile groups of Lp-PLA2 (p=0.62). Although Lp-PLA2 among both populations correlated positively with LDL and total cholesterol, American and Japanese men had different correlations with NMR lipoprotein subclasses. Reported high odds ratio for CCS>0 among American compared to Japanese men was not reduced after adjusting for Lp-PLA2 levels.CONCLUSION: Lp-PLA2 may have different mechanisms of action among American and Japanese men. Lp-PLA2 levels can not explain the observed CAC differences between the two populations.J Epidemiol 2007; 17: 179-185.

• 日本疫学会の論文
• 2007-11-01

著者

• Ueshima Hirotsugu

  Department of Health Science, Shiga University of Medical Science

• Okamura Tomonori

  Department of Preventive Cardiology, National Cardiovascular center

• Kadowaki Takashi

  Department of Health Science, Shiga University of Medical Science

• Sekikawa Akira

  Department of Epidemiology, Graduate School of Public Health, University of Pittsburg

• Kawano Yuhei

  国立循環器病センター 高血圧腎臓内科

• Ueshima Hirotsugu

  滋賀大学 医学部健康科学科

• Takebayashi T

  Department Of Preventive Medicine And Public Health School Of Medicine Keio University

• KITA Yoshikuni

  Department of Health Science, Shiga University of Medical Science

• Kondo Takaaki

  Department Of Internal Medicine Division Of Cardio-vascular Medicine

• Kadowaki Takashi

  滋賀大学 医学部健康科学科

• Katanosaka Yuki

  国立循環器病センター

• Takamiya Tomoko

  Department of Preventive Medicine and Public Health, Tokyo Medical University

• Kadowaki Takashi

  Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo

• Obara Taku

  東北大学 臨床薬学

• Kosakai Yoshio

  Department Of Cardiovascldar Surgery National Cardiovascudar Center

• Tamakoshi A

  Department Of Health Science Shiga University Of Medical Science

• Takezaki T

  Department Of International Island And Community Medicine Graduate School Of Medical And Dental Scie

• Takahashi Ken

  Department Of Preventive Medicine And Public Health School Of Medicine Keio University

• Kuller Lewis

  Department Of Epidemiology Graduate School Of Public Health. University Of Pittsburgh

• Tamakoshi Koji

  Dep. Of Public Health - Health Information Dynamics Nagoya Univ. Graduate School Of Medicine

• Kita Yoshikuni

  Department Of Health Science Shiga University Of Medical Science

• Okubo Takayoshi

  Department Of Planning For Drug Development And Clinical Evaluation Tohoku University

• Takagi Kenzo

  Third Division Of The Research Laboratory For Development Of Medicine School Of Pharmacy Hokuriku Un

• Takagi Kenzo

  School Of Health Sciences Nagoya University

• Kawase Takakazu

  Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute

• Ueshima Hirotsugu

  Department Of Health Sceicne Shiga University Of Medical Science

• Yoshita Katsushi

  Project For The National Health And Nutrition Survey National Institute Of Health And Nutrition

• Takamiya Tomoko

  Department Of Epidemiology Graduate School Of Public Health. University Of Pittsburgh

• Takemiya Kiyoko

  Department Of Internal Medicine Division Of Cardio-vascular Medicine Kurume University School Of Med

• EL-SAED Aiman

  Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh

• ZAKY Riad

  Department of Epidemiology, Graduate School of Public Health. University of Pittsburgh

• EDMUNDOWICZ Daniel

  Preventive Cardiology, Cardiovascular Institute, University of Pittsburgh Medical Center Health Plan

• Ueshima Hirotsugu

  The Research Committee For Primary Hyperlipidemia Research On Measures For Intractable Diseases By T

• Edmundowicz Daniel

  Preventive Cardiology Cardiovascular Institute University Of Pittsburgh Medical Center Health Plan

• Kondo Takaaki

  名古屋大学 医学部保健学科

• Okamura Tomonori

  Department Of Cardiology National Cardiovascular Center

• Zaky Riad

  Department Of Epidemiology Graduate School Of Public Health. University Of Pittsburgh

• El-saed Aiman

  Department Of Epidemiology Graduate School Of Public Health. University Of Pittsburgh

• Sekikawa Akira

  Department Of Epidemiology Graduate School Of Public Health University Of Pittsburg

• Takahashi Ken

  Japan Industrial Safety And Health Association

• Tanaka Taichiro

  Department Of Health Sciences School Of Medicine University Of Yamanashi

• Kuller Lewis

  Department Of Epidemiology Graduate School Of Public Health University Of Pittsburgh

• Kadowaki Takashi

  Department Of Cardiology Kawasaki Medical School

• TAKAMIYA Tomoko

  Department of Biological Science & Technology, Faculty of Industrial Science & Technology, Tokyo University of Science

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