An Occupational Health Study of Emergency Physicians in Japan : Health Assessment by Immune Variables (CD4, CD8, CD56, and NK Cell Activity) at the Beginning of Work

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概要

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• This study was conducted to evaluate the occupational health of Japanese physicians in emergency medicine. Subjects participating in this study were eighty-nine physicians working at 12 medical facilities (10 critical care emergency centers) in Japan. Participants were asked to complete a questionnaire of work conditions and to provide blood samples for immune variable measurements (CD4, CD8, CD56 and natural killer cell (NK cell) activity) before commencing their work. The data collected from seventy-four of 89 participating physicians were analyzed. The traditional work group comprised of 39 emergency physicians, who were significantly overworked compared to other two groups: the shift work group and the day work group. Among these three groups, no immune variable was significantly different except lymphocyte, number of CD4, and NK cell activity; and the NK cell activity of the shift work group was significantly lower than those of the traditional work group (p<0.01) and the day work group (p<0.01) in terms of Bonferroni's multiple comparison, probably due to circadian rhythm. It was indicated that NK cell activity was significantly lower in samples collected at night versus in the morning (OR=8.34, 95%Cl: 1.95-35.6, p<0.01) through multiple logistic regression analyses. NK cell activity was significantly lower in individuals taking 0-3 days off per month, as compared to those taking 4 or more days off (OR=4.65, 95%Cl: 1.27-17.0, p=0.02), according to multiple logistic regression analyses. Therefore, the low NK cell activity appears to have reflected the extent of fatigue arising from physicians' overwork. Overwork would have been a potential risk for the physicians' health, resulting in a lower quality of Japanese emergency medical services than that which could have been achieved otherwise. This study suggests that it would be better for the Japanese emergency physicians to take 4 or more days off per month for their health and the quality of their services.

• 社団法人日本産業衛生学会の論文

著者

• Takeda Nobuo

  Department of Pharmacotherapeutics, Faculty of Pharmaceutical Sciences, Setsunan University, Japan

• Tanaka Nobukazu

  Kyorin Univ. School Of Medicine Tokyo Jpn

• UEMURA Takamoto

  Department of Preventive Medicine and Public Health, School of Medicine, Keio University

• TERUYA Koji

  Department of Anesthesiology, Faculty of Medicine, University of the Ryukyus

• Teruya Koji

  Department Of Preventive Medicine And Public Health School Of Medicine Kyorin University:department

• Teruya Koji

  Department Of Anesthesiology Faculty Of Medicine University Of The Ryukyus

• Takagi Y

  Division Of Cardiovascular Surgery Kamo Hospital

• Matsui Tomoko

  Department Of Preventive Medicine And Public Health School Of Medicine Kyorin University

• ICHIKAWA Kaoru

  Department of Preventive Medicine and Public Health, School of Medicine, Kyorin University

• TSUNODA Tooru

  Department of Preventive Medicine and Public Health, School of Medicine, Kyorin University

• OKAMOTO Hiroteru

  Department of Preventive Medicine and Public Health, School of Medicine, Kyorin University

• FUKAZAWA Shinji

  Department of Preventive Medicine and Public Health, School of Medicine, Kyorin University

• TSUCHIDA Kosuke

  Department of Preventive Medicine and Public Health, School of Medicine, Kyorin University

• TAKEMAE Rieko

  Department of Preventive Medicine and Public Health, School of Medicine, Kyorin University

• TAKASHIMA Yutaka

  Department of Preventive Medicine and Public Health, School of Medicine, Kyorin University

• Takeda Nobuo

  Department Of Preventive Medicine And Public Health School Of Medicine Kyorin University

• Takemae Rieko

  Department Of Preventive Medicine And Public Health School Of Medicine Kyorin University

• Tsunoda Tooru

  Department Of Preventive Medicine And Public Health School Of Medicine Kyorin University

• Ichikawa Kaoru

  Department Of Preventive Medicine And Public Health School Of Medicine Kyorin University

• Tsuchida Kosuke

  Department Of Preventive Medicine And Public Health School Of Medicine Kyorin University

• Uemura Takamoto

  Department Of Preventive Medicine And Public Health School Of Medicine Kyorin University

• Uemura Takamoto

  Department Of Preventive Medicine And Public Health School Of Medicine Keio University

• Fukazawa Shinji

  Department Of Preventive Medicine And Public Health School Of Medicine Kyorin University

• Takashima Yutaka

  Department Of Public Health Kyorin University School Of Medicine

• Matsui Tomoko

  Department Of Acoustic And Speech Research Advance Telecommunications Research Institute Internation

• Ichikawa Kaoru

  Department Of Applied Chemistry Graduate School Of Engineering Tokyo University Of Agriculture And T

• Takeda Nobuo

  Department Of Pharmacotherapeutics Faculty Of Pharmaceutical Sciences Setsunan University

• Okamoto Hiroteru

  Department Of Preventive Medicine And Public Health School Of Medicine Kyorin University

• Takeda Nobuo

  Department Of Advanced Energy Graduate School Of Frontier Sciences And Department Of Aeronautics And

• TAKASHIMA YUTAKA

  Department of Microbiology Public Health, School of Medicine, Keio University.

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