Increased Risk of Obesity Resulting from the Interaction between High Energy Intake and the Trp64Arg Polymorphism of the .BETA.3-adrenergic Receptor Gene in Healthy Japanese Men
スポンサーリンク
概要
- 論文の詳細を見る
BACKGROUND: Few studies have investigated the interaction between the Trp64Arg polymorphism of the β3-adrenergic receptor gene (ADRB3) and environmental factors. This study aimed to investigate whether energy intake affects the relationship between this polymorphism and obesity.METHODS: Healthy Japanese men (n=295; age 46.1±11.5 years (mean ±standard deviation); waist circumference 83.9±9.3 cm; body mass index (BMI) 23.3±3.3 kg/m2) recruited in a Japanese chemical industry firm were eligible for analysis. Daily energy intake, protein, fat, and carbohydrate (PFC) ratio and daily physical activity were assessed by self-reported questionnaires. Genotyping for the polymorphism was performed with written informed consent.RESULTS: When the subjects were classified into two groups according to presence of the polymorphism, the groups were not significantly different in waist circumference or BMI. Quartile classification of energy intake, however, demonstrated a significantly larger ratio of obese subjects to non-obese subjects in the group with the polymorphism in the highest 4th quartile alone. Multiple logistic regression analysis also revealed that the presence of the polymorphism increased the risk of obesity significantly in the 4th quartile alone (adjusted odds ratio=3.37, 95% confidence interval=1.12-10.2).CONCLUSION: Presence of the polymorphism alone does not significantly increase the risk of obesity. However, high energy intake interacts with the polymorphism and leads to a significant increase in risk of obesity. The Trp64Arg polymorphism of ADRB3 warrants consideration, along with other polymorphisms involved in the development of obesity, for tailor-made prevention of obesity.J Epidemiol 2005; 15: 203-210.
著者
-
Omae Kazuyuki
Department Of Preventive Medicine And Public Health Keio University School Of Medicine
-
Murata Mitsuru
Department Of Internal Medicine School Of Medicine Keio University
-
Kikuchi Haruhito
Department Of Laboratory Medicine School Of Medicine Keio University
-
Miyaki Koichi
Department Of Clinical Research And Informatics National Center For Global Health And Medicine
-
Takei Izumi
Department Of Internal Medicine Center For Diabetes And Endocrinology Ichikawa General Hospital Tokyo Dental College
-
WATANABE KIYOAKI
Department of Internal Medicine, School of Medicine Keio University
-
Watanabe Kiyoaki
Department of Laboratory Medicine, School of Medicine, Keio University.
-
Murata Mitsuru
Department of Laboratory Medicine, School of Medicine, Keio University.
-
Sutani Shinya
Department of Preventive Medicine and Public Health, School of Medicine, Keio University.
関連論文
- Effects of SO_2 on Respiratory System of Adult Miyakejima Resident 2 Years after Returning to the Island
- Biological Monitoring of Indium by Means of Graphite Furnace Atomic Absorption Spectrophotometry in Workers Exposed to Particles of Indium Compounds
- Lack of Relationship between Occupational Exposure to Carbon Disulfide and Endocrine Dysfunction : A Six-year Cohort Study of the Japanese Rayon Workers
- Uptake of Cadmium in Meals from the Digestive Tract of Young Non-smoking Japanese Female Volunteers
- Urinary Excretion of TTCA after Intake of brassica Vegetables
- Cross-Sectional Study of Health Effects of Methyl Methacrylate Monomer among Dental Laboratory Technicians
- Four-Week Inhalation Toxicity Study of 2, 2-Dichloro-1, 1, 1-trifluoroethane(HCFC-123) in Guinea Pigs
- Acute and Recurrent Hepatitis Induced by 2, 2-Dichloro-1, 1, 1-trifluoroethane (HCFC-123)
- Relationship Between the Blood Coagulation-Fibrinolysis System and the Subclinical Indicators of Arteriosclerosis in a Healthy Male Population
- Stabilometry in Epidemiologieal Use : Measurement Bias by Different Instructions
- Environmental and Biological Monitoring of 2, 2-Dichloro-1, 1, 1-trifluoroethane (HCFC-123)
- Exposure to 2, 2-Dichloro-1, 1, 1-trifluoroethane (HCFC-123) and Acute Liver Dysfunction: A Causal Inference
- Toxicity of Silicon Compounds in Semiconductor Industries
- Toxicity of Intratracheally-administered Indium Phosphide(InP)in Rats.
- Acute Liver Dysfunction among Workers Exposed to 2, 2-Dichloro-1, 1, 1-trifluoroethane (HCFC-123) : A Case Report
- Respiratory Diseases and Working in a Copper or an Aluminum Product Plant:A Case Control Study by Using Medical Records
- A Simple Method for Carbon Disulfide Monitoring Using a Diffusive Sampler, Thermal Desorption and a Stain Tube
- A second national questionnaire survey of TMA
- Genotoxicity Studies of Heavy Metals : Lead, Bismuth, Indium, Silver and Antimony
- Oral Toxicity of Indium in Rats : Single and 28-Day Repeated Administration Studies
- Oral Toxicity of Bismuth in Rat : Single and 28-Day Repeated Administration Studies
- A 13-Week Toxicity Study of Bismuth in Rats by Intratracheal Intermittent Administration
- Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca^ channels in the heart
- The Ratio of Serum Paraoxonase/Arylesterase Activity Using an Improved Assay for Arylesterase Activity to Discriminate PON1_ from PON1_
- National questionnaire survey of TMA
- Shear stress-induced platelet aggregation in various types of von Willebrand disease
- Effects of Intratracheally Administered Indium Phosphide on Male Fischer 344 Rats
- Effects of DHMEQ, a Novel Nuclear Factor-κB Inhibitor, on Beta Cell Dysfunction in INS-1 Cells
- Surgical site infection surveillance after open gastrectomy and risk factors for surgical site infection
- A Simple Method to Induce Differentiation of Murine Bone Marrow Mesenchymal Cells to Insulin-producing Cells Using Conophylline and Betacellulin-delta4
- Nitric Oxide Is lmportant for Mouse Beta-Cell Line Killing by Peritoneal Exudate Cells Obtained from Cyclophosphamide Treated Non-Obese Diabeitc Mice
- Reference Values for Urinary Steroids in Japanese Newborn Infants : Gas Chromatography/Mass Spectrometry in Selected Ion Monitoring
- Hyperglycemia Decreases Dehydroepiandrosterone in Japanese Male with Impaired Glucose Tolerance and Low Insulin Response
- Association of Thoracic Kyphosis with Subjective Poor Health, Functional Activity and Blood Pressure in the Community-Dwelling Elderly
- Administration of Conophylline and Betacellulin-δ4 Increases the β-cell Mass in Neonatal Streptozotocin-treated Rats
- High throughput multiple combination extraction from large scale polymorphism data by exact tree method
- Central line-associated bacteremia caused by drug-resistant Staphylococcus caprae after chemotherapy for acute myelogenous leukemia
- Low prevalence of activated protein C resistance and coagulation factor V Arg^ to Gln mutation among Japanese patients with various forms of thrombosis, and normal individuals
- Acute promyelocytic leukemia developed in a patient with congenital antithrombin III deficiency
- OE-015 Peripheral Blood Level of Matrix Metalloprotease-9 is Elevated in Patients with Acute Aortic Dissection(Emergency care-1 (H) OE3,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Hemophagocytic syndrome associated with fulminant hepatitis A : a case report
- Assessment of tailor-made prevention of atherosclerosis with folic acid supplementation : randomized, double-blind, placebo-controlled trials in each MTHFR C677T genotype
- Short-term Changes in Cadmium in Feces, Blood and Urine after Dietary Cadmium Intake in Young Japanese Females
- Cadmium Concentration in Current Japanese Foods and Beverages
- N,N-Dimethylformamide (DMF) Vapor Absorption through the Skin in Workers
- A Cross-Sectional Observation of the Effects of Hydrazine Hydrate on Workers' Health
- In Vitro Solubility and In Vivo Toxicity of Indium Phosphide
- Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan
- Secular Trends and Geographical Variations in the Dietary Intake of Polybrominated biphenyl Ethers (PBDEs) Using Archived Samples from the Early 1980s and Mid 1990s in Japan
- Assessment of Conventional and New Prediction Algorithm for Multifactorial Disease Diagnosis
- Novel Statistical Classification Model of Type 2 Diabetes Mellitus Patients for Tailormade Prevention Using Data Mining Algorithm
- Causal Relationship between Indium Compound Inhalation and Effects on the Lungs
- Urinary Excretion of an Oxidative Stress Marker, 8-hydroxyguanine (8-OH-Gua), among Nickel-cadmium Battery Workers
- Effects of Sarin on the Nervous System of Subway Workers Seven Years after the Tokyo Subway Sarin Attack
- Two New Criteria of the Metabolic Syndrome : Prevalence and the Association with Brachial-Ankle Pulse Wave Velocity in Japanese Male Workers
- Toxicity of Fire Decomposition Products of New Fire Extinguishing Agent, 1, 1, 1, 2, 3, 3, 3-Heptafluoropropane
- Acute and Subacute Inhalation Toxicity of Highly Purified Phosphine (PH_3) in Male ICR Mice
- An HIV Autopsy : Characterization of Zidovudine-resistant Subtype E HIV-1 from Autopsy Tissue Suggests the Route of Infection and an Alternative Protocol of Therapy
- Interaction of Angiotensin I-Converting Enzyme Insertion-Deletion Polymorphism and Daily Salt Intake Influences Hypertension in Japanese Men
- Parachute mitral valve incidentally diagnosed in an adult patient with hypertension
- Changes of Intestinal Flora of Young Japanese Females Resulting from Two-Week Common Diet and Living in the Same Dormitory
- Inherited Factors That May Influence the Individual Sensitivity to Antiplatelet Drugs(New Trend of Anti-thrombotic Drugs, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Genotype frequency of plasminogen activator inhibitor-1(PAI-1) 4G/5G polymorphism in healthy japanese males and its relation to PAI-1 Levels
- An Effective Quarantine Measure Reduced the Total Incidence of Influenza A H1N1 in the Workplace : Another Way to Control the H1N1 Flu Pandemic
- Epidemiology of primary immune thrombocytopenia in children and adults in Japan : a population-based study and literature review
- Novel Statistical Classification Model of Type 2 Diabetes Mellitus Patients for Tailormade Prevention Using Data Mining Algorithm
- Assessment of Workplace Air Concentrations of Indium Dust in an Indium-recycling Plant
- Exposure Assessment of ETBE in Gas Station Workers and Gasoline Tanker Truck Drivers
- Free cortisol/cortisone ratio in pooled urine was increased after rapid-ACTH stimulation test under dexamethasone suppression
- International clinical harmonization of glycated hemoglobin in Japan : From Japan Diabetes Society to National Glycohemoglobin Standardization Program values
- Increased Risk of Obesity Resulting from the Interaction between High Energy Intake and the Trp64Arg Polymorphism of the .BETA.3-adrenergic Receptor Gene in Healthy Japanese Men
- Association of GLUT4 gene variants with HbA1c level in Japanese men
- Influence of Loxoprofen Use on Recovery from Naturally Acquired Upper Respiratory Tract Infections: A Randomized Controlled Trial
- FIBRINOLYTIC ACTIVITY OF LEUKEMIC CELLS
- Antibodies against platelet major glycoproteins in patients with chronic idiopathic thrombocytopenic purpura.