Antibodies against platelet major glycoproteins in patients with chronic idiopathic thrombocytopenic purpura.

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概要

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• We have developed a simple and sensitive enzyme linked immunosorbent assay (ELISA) to detect antibodies against the platelet major glycoproteins, GPIb and GPIIb/IIIa complex. Briefly, the glycoproteins were immobilized in the microtiter wells by addition of Nonidet P 40 lysates of human platelets to the wells coated with mouse monoclonal antibodies against either GPIb or GPIIb/IIIa complex. Serum from patient was added to each well and antibody bound to the glycoproteins was detected by peroxidase conjugated goat anti-human IgG.Sera from 4 out of 43 patients with ITP were found to have antibodies against GPIb, while sera from 2 out of 43 had antibodies against GPIIb/IIIa complex. Analysis of clinical as well as laboratory characteristics of the patients failed to demonstrate any significant features that would distinguish the patients with the anti-glycoprotein antibodies from those without.

• The Keio Journal of Medicineの論文

著者

• ANDO Yasuhiko

  Department of Blood Transfusion Service Center Tokai University Hospital

• Toyama Keisuke

  Department Of Hematology And Oncology Nagoya University Graduate School Of Medicine

• WATANABE KIYOAKI

  Department of Internal Medicine, School of Medicine Keio University

• IKEDA YASUO

  Blood Center, School of Medicine, Keio University

• Murakami Hiroshi

  Department of Applied Chemistry, Nagoya Institute of Technology

• ANDO YASUHIKO

  Department of Laboratory Medicine School of Medicine, Keio University

• SATOH KUNIHIKO

  Department of Internal Medicine, School of Medicine, Keio University

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