Postnatal Lymphotoxin-.ALPHA.-Mediated Signals Reorganize Splenic Microarchitecture
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概要
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In this study, we assessed the roles of postnatal lymphotoxin (LT)-α mediated signaling in the maintenance of the microarchitecture of the fully developed spleen. To investigate the role of postnatal LT-α-mediated signals in the organization of splenic microarchitecture, wild-type (LTα+/+) mice were lethally irradiated and then reconstituted with LT-α deficient (LTα-/-) bone marrow. The transfer of LTα-/- bone marrow to those mice resulted in the disruption of splenic microarchitecture, including the segregation of T and B cell areas, and the formation of germinal centers and follicular dendritic cell clusters. In contrast, adoptive transfer of LTα+/+ bone marrow to LTα-/- mice restored the segregation of T and B cell areas and the formation of the germinal center and follicular dendritic cell cluster in the spleen. These results suggest that the maintenance of splenic microarchitecture is not programmed during development but is dependent on constant stimuli provided by LTα.
著者
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Fukatsu Akira
Department Of Comprehensive Clinical Dentistry Research Institute Of Oral Science Nihon University S
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Fukumoto Masahiko
Department Of Comprehensive Clinical Dentistry Research Institute Of Oral Science Nihon University S
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Tanaka Shunichi
Department Of Applied Physics Faculty Of Engineering University Of Tokyo
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Murakami Hiroshi
Department Of Biochemistry And Cell Biology Graduate School Of Medicine Nagoya City University
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Yamamoto Hirotsugu
Department of Optical Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1, Minamijosanjima-cho, Tokushima 770-8506, Japan
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YAMAMOTO Masafumi
Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Chiba University
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Morikawa-Saito Miyuki
Department of Oral Pathology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, 271-8587, Japan
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Morikawa-Saito Miyuki
Departments of Oral Pathology, Nihon University School of Dentistry at Matsudo
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Murakami Hiroshi
Departments of Oral and Maxillofacial Implantology, Nihon University School of Dentistry at Matsudo
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Murakami Hiroshi
Department of Applied Chemistry, Nagoya Institute of Technology
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Tanaka Shunichi
Departments of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo
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