A case of autoimmune neutropenia and thrombocytopenia. Effect of high-dose intravenous immunoglobulin.:EFFECT OF HIGH-DOSE INTRAVENOUS IMMUNOGLOBULIN
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概要
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We have recently observed a case of autoimmune neutropenia and thrombocytopenia of a fifteen-year-old girl. Prednisone was first given, leading to complete remission of thrombocytopenia, but without effect on neutrophil count. Severe thrombocytopenia recurred, however, after repeated upper respiratory infection and the high-dose intravenous immunoglobulin (HDIVIgG) at a dosage of 0.4 g/kg/day was administered for 5 days. There was almost no increase in platelet count, but the neutrophil count became normalized. Prior to splenectomy, HDIVIgG therapy was again performed at a dosage of 0.6g/kg/day. Both platelets and neutrophils were dramatically increased. These observations may help us to understand the mechanism of action of HDIVIgG.
- The Keio Journal of Medicineの論文
著者
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Toyama Keisuke
Department Of Hematology And Oncology Nagoya University Graduate School Of Medicine
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Kikuchi Masao
Department Of Internal Medicine Shizuoka Red Cross Hospital
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Murakami Hiroshi
Department Of Biochemistry And Cell Biology Graduate School Of Medicine Nagoya City University
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KIKUCHI MASAO
Department of Internal Medicine, Tachikawa Kyosai Hospital
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IKEDA YASUO
Blood Center, School of Medicine, Keio University
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Murakami Hiroshi
Department of Applied Chemistry, Nagoya Institute of Technology
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MURAKAMI HIROSHI
Department of Internal Medicine, Tachikawa Kyosai Hospital
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TOYAMA KEISUKE
Department of Internal Medicine, School of Medicine, Keio University
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