The Fission Yeast php2 Mutant Displays a Lengthened Chronological Lifespan

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概要

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• The Schizosaccharomyces pombe php2+ gene encodes a subunit of the CCAAT-binding factor complex. We found that disruption of the php2+ gene extended the chronological lifespan of the fission yeast. Moreover, the lifespan of the Δphp2 mutant was barely extended under calorie restricted (CR) conditions. Many other phenotypes of the Δphp2 mutant resembled those of wild-type cells grown under CR conditions, suggesting that the Δphp2 mutant might undergo CR. The mutant also showed low respiratory activity concomitant with decreased expression of the cyc1+ and rip1+ genes, both of which are involved in mitochondrial electron transport. On the basis of a chromatin immunoprecipitation assay, we determined that Php2 binds to a DNA region upstream of cyc1+ and rip1+ in S. pombe. Here we discuss the possible mechanisms by which the chronological lifespan of Δphp2 mutant is extended.

• 公益社団法人 日本農芸化学会の論文

著者

• Aiba Hirofumi

  Laboratory Of Microbiology Faculty Of Agriculture Nagoya University

• Azuma Kenko

  Laboratory Of Molecular Microbiology Graduate School Of Bioagricultural Sciences Nagoya University

• Ohtsuka Hokuto

  Laboratory Of Molecular Microbiology Graduate School Of Bioagricultural Sciences Nagoya University

• Murakami Hiroshi

  Department Of Biochemistry And Cell Biology Graduate School Of Medicine Nagoya City University

• AIBA Hirofumi

  Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University

• TAKUMA Kazuaki

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• Murakami Hiroshi

  Department of Applied Chemistry, Nagoya Institute of Technology

• MURAKAMI Hiroshi

  Department of Biological Science, Faculty of Science and Engineering, Chuo University

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