Expression of VEGF, VEGF-R2, bFGF and FGF-R in Oral Capillary Hemangioma
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概要
- 論文の詳細を見る
Oral capillary hemangioma (OCH) is a benign hamartomatous lesion that exhibits a proliferation of capillary endothelial cells and abnormal capillary formation. Its occurrence is relatively common in the oral cavity, yet the pathogenesis is not well understood. To elucidate the mechanism of OCH development, we examined the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), as well as their receptors (VEGF-R2, FGF-R), in OCH of 45 patients using an immunohistochemical staining method. More than 50% of the endothelial cells and the stromal cells of OCH showed significantly elevated expression of VEGF or/and bFGF, accompanied with an increase in the expression of their receptors. The increased number of capillary vessels in OCH was positively correlated with the expression level of these angiogenic factors. Our data indicate that the pathogenesis of OCH is closely associated with overexpression of angiogenic factors, which may result in autocrine or paracrine stimulation of endothelial cells and their precursors.
- 特定非営利活動法人日本臨床口腔病理学会の論文
- 2003-09-25
著者
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Takagi Minoru
東京医科歯科大学 院 口腔機能再建学 講座 分子病態学
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Takagi Minoru
Department Of Oral Surgery Nihon University School Of Dentistry At Matsudo
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YAMAMOTO Hirotsugu
Department of Oral Pathology, Nihon University School of Dentistry
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Chuai Man-li
Molecular Pathology Graduate School Of Tokyo Medical And Dental University
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TAKAGI Minoru
Molecular Pathology, Department of Oral Resttitution, Division of Oral Health Sciences
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Sakamoto Kei
Molecular Pathology, Oral Restitution, Oral Health Sciences, Graduate School, Tokyo Mediacal and Den
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Sakamoto Kei
Molecular Pathology Department Of Oral Restitution Pulp Biology And Endodontics Department Of Restor
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Yamamoto Hirotsugu
Department Of Oral Pathology And Clinical Laboratory Nihon University School Of Dentistry At Matsudo
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OKADA Norihiko
Department of Diagnostic Oral Pathology, Dental Hospital, Tokyo Medical and Dental University
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Iseki Hachiro
Molecular Pathology, Graduate School of Tokyo Medical and Dental University
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Makino Takafumi
Department of Oral Surgery, Nihon University School of Dentistry at Matsudo
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Okada Norihiko
Laboratory Medicine, Graduate School of Tokyo Medical and Dental University
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Iseki Hachiro
Molecular Pathology Graduate School Of Tokyo Medical And Dental University
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Iseki Hachiro
Department Of Neurobiology Graduate School Tokyo Medical And Dental University
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Takagi Minoru
Molecular Pathology Department Of Oral Restitution Pulp Biology And Endodontics Department Of Restor
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Okada Norihiko
Diagnostic Oral Pathology Department Of Oral Restitution Pulp Biology And Endodontics Department Of
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Iseki Hachiro
Section Of Biostructural Science Graduate School Of Tokyo Medical And Dental University
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Okada Norihiko
Laboratory Medicine Graduate School Of Tokyo Medical And Dental University
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Takagi Minoru
Molecular Pathology Department Of Oral Restitution Division Of Oral Health Sciences Graduate School
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Yamamoto Hirotsugu
Department of Oral Pathology, Nihon University School of Dentistry at Matsudo
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Yamamoto Hirotsugu
Department of Optical Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1, Minamijosanjima-cho, Tokushima 770-8506, Japan
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