Immunohistochemical Localization of Relaxin in Rat Periodontal Ligaments, Dental Pulp Tissue, and Midpalatal Suture
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概要
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Relaxin (RLX) is a hormone in the insulin/RLX family of structurally related hormones. It has been shown to bind to receptors LGR7 and LGR8 in the leucine-rich repeat-containing G-protein-coupled receptor family. Furthermore, RLX influences many other physiologic processes such as collagen turnover, angiogenesis, and antifibrosis. Immunohistochemical studies have reported that RLX was localized in ovarian and other tissues. The present study focused on the localization of RLX in rat periodontal ligaments, midpalatal suture, and dental pulp tissue. To determine the localization of RLX proteins, an immunohistochemical study was performed. Positive immunoreactivity for RLX was identified in osteoblasts, osteoclasts, fibroblasts, collagen fibers, odontoblasts, and predentin in the periodontal ligaments, dental pulp, and midpalatal suture. Therefore, RLX may be involved in the process of collagen metabolism in the oral tissues.
著者
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Yamaguchi Masaru
Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido
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YAMAMOTO Hirotsugu
Department of Oral Pathology, Nihon University School of Dentistry
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Utsunomiya Tadahiko
Departments of Oral Pathology, Nihon University School of Dentistry at Matsudo
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Kubo Rie
Departments of Orthodontics, Nihon University School of Dentistry at Matsudo
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Kasai Kazutaka
Departments of Orthodontics, Nihon University School of Dentistry at Matsudo
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