Antigenicity of Metabolic Products of Air-borne Fungi
スポンサーリンク
概要
- 論文の詳細を見る
Antigenicities of oosponol(4-hydroxymethyl ketone-8-hydroxyisocoumarine) and KI(4-1', 2'-dihydro-xethyhyl-8-hydroxyisocoumarine), which were metabolic products of an air-borne fungi, oospora astringenes, collected in the room of bronchial asthmatic patients, was investigated by means of Schulz-Dale's and Konzett-Lossler's methods in guinea pigs. Physiological saline solutions, these solutions added with Freund's complete adjuvant and guinea pig's serum dilutions of 7 mg/ml of KI or oosponol containing the adequate volume of the adjuvant were used for the sensitizing antigens. Sensitization by injections of all of the solutions of KI were found unsuccessfull and the guinea pigs could not be sensitized by injection of physiological saline solution of oosponol even with the adjuvant. The animals sensitized with blend of oosponol, guinea pig's serum and the adjuvant were well responsive for challenge by guinea pig's serum dilution with oosponol. The response was found very remarkable, when the blended serum was used for sensitization after incubation at 38℃ during 48 hrs. The desensitization was evidenced in constrictive reaction in the isolated smooth muscle preparations, but the challenge by oosponol alone was impossible. Results of Schulz-Dale's reaction in small intestines from the guinea pigs sensitized with oosponol-serum protein fractions and electrophotometrical analysis on the blended serum showed that antigen-like principle presented in oosponol-albumin fraction. These facts above mentioned suggested that oosponol interacted with serum albumin and that some new substances possessing antigenic activity were formed. The air-borne fungi and their metabolic products being in house dust could be suspected to play an important role in ethiology of asthmatic attack.
- 日本アレルギー学会の論文
- 1967-02-28
著者
-
Yamaguchi Masaru
Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido
-
Ohashi Shigeru
Department Of Pharmacology Nippon Medical School
-
Okamura Tadao
Department of Pharmacology, Nippon Medical School
-
Takeuchi Setsuya
Department of Pharmacology, Nippon Medical School
-
Okamura Tadao
Department Of Pharmacology Nippon Medical School
-
Takeuchi Setsuya
Department Of Pharmacology Nippon Medical School
-
Yamaguchi Masaru
Department Of Chemistry Faculty Of Science Kyushu University
-
Yamaguchi Masaru
Department Of Pharmacology Nippon Medical School
-
Ohashi Shigeru
Department of Chemistry Faculty of Science Kanazawa University
-
山口 優
Department of Pharmacology, Nippon Medical School
関連論文
- An Immunohistochemical Study of the Localization of Inducible Nitric Oxide Synthase (iNOS) and Heat Shock Protein (HSP) in Pleomorphic Adenoma
- Histopathological Study of Inhibitory Effects for Relapse by Relaxin after Expansion in Rat Midpalatal Suture
- Immunohistochemical Localization of Relaxin in Rat Periodontal Ligaments, Dental Pulp Tissue, and Midpalatal Suture
- Almost Periodic and Asymptotically Almost Periodic Solutions of Some Wave Equations with Quasiperiodic Coefficients
- Localization of RANKL and cathepsin K, B and L in rat periodontal tissues during experimental tooth movement
- Cathepsins B and L Increased during Response of Periodontal Ligament Cells to Mechanical Stress In Vitro
- The level of cathepsin L in gingival crevicular fluid during orthodontic tooth movement and effect of tension-force on cathepsin L activity from periodontal ligament cells
- Relaxin Modulates Collagen Type I and Matrix Metalloproteinase-1 Expression by Human Periodontal Ligament Cells
- Expression of Heat Shock Protein 70 in the Periodontal Ligament During Orthodontic Tooth Movement
- Antigenicity of Metabolic Products of Air-borne Fungi
- HYPOGLYCEMIC EFFECT OF 3-AZA BICYCLO 3, 3, 1 NONANES IN RATS AND RABBITS
- Existence and Stability of Bounded and Almost Periodic Solutions of Perturbed Quasilinear Partial Differential Equations of Standard Types
- Almost Periodic Solutions of Undamped Linear Wave Equations
- Note on Quasiperiodic Solutions of Undamped Linear Wave Equations
- Improvement on Automatic Bubble Flowmeter
- STUDIES ON INTRAVENOUS GLUCOSE TOLERANCE CURVE : 6. EFFECT OF ADRENERGIC BLOCKING AGENTS
- On the Existence of Quasiperiodic Solutions of Nonlinear Partial Differential Equations
- Nonexistence of Bounded Solutions of Some Linear Evolution Equation with Periodic Forcing Term
- SLB10 NEW METHODOLOGIES FOR THE SYNTHESIS OF NATURAL PRODUCTS
- Note on Periodic Solutions of Undamped Nonlinear Oscillation Systems
- CORRELATION BETWEEN GLUCOSE BASAL UPTAKE AND INSULIN EFFECT IN RAT-DIAPHRAGM METHOD
- IL-6 and IL-17 in the Gingival Crevicular Fluid During Orthodontic Root Resorption
- Effects of Relaxin on Relapse After Experimental Tooth Movement in Rats
- Relaxing action of adrenergic β_2-agonists on guinea-pig skinned tracheal muscle
- ANAPHYLACTIC CONTRACTION AND POTASSIUM CONCENTRATION IN INCUBATION MEDIUM IN GUINEA-PIG'S TAENIA COLI
- INHIBITORY ACTION OF SOME ANTIHISTAMINICS ON THE ANAPHYLACTIC CONTRACTION IN GUINEA PIG'S TAENIA COLI
- Total Syntheses of Renieratene and Renierapurpurin
- Some Copper Complexes of Diazoaminobenzene Derivatives and their Properties
- The Reactions of Lower Oxo Acids of Phosphorus with the Molybdenum(V)-Molybdenum(VI) Reagent
- Determination of Ortho-, Pyro- and Tripolyphosphate by the Use of α Small Column of Ion-exchange Resin
- Effects of Indentation Load on the Mechanical Behavior of Orthodontic Wire Alloys by Dynamic Micro-Indentation Method
- Levels of IL-17, RANKL and OPG in Gingival Crevicular Fluid Obtained from Patients with Severe Orthodontic Root Resorption
- Immunohistochemical Localization of T-helper 17 Cells, IL-17, and RANKL during Root Resorption Induced by Excessive Orthodontic Force in the Mouse Model of T Cell-mediated Autoimmune Disease
- Localization of TNF-α and Macrophages in the Periodontal Ligament during Orthodontic Tooth Movement
- Phosphonylation of biomolecules with inorganic diphosphonate. II. Phosphonylation of phosphate groups on nucleoside 5'-monophosphates, deoxynucleoside 5'-monophosphates, and sugar phosphates.
- The reaction of cyclo-triphosphate with ethanolamines.
- The reaction of cyclo-triphosphate with ethylenediamine.
- The reaction of cyclo-triphosphate with L-.ALPHA.- or .BETA.-alanine.
- The synthesis of tedanin and its isomer, 3-hydroxy-2,3-didehydro-.BETA.,.PHI.-caroten-4-one.
- The reaction of cyclo-triphosphate with L-valine.
- A rapid esterification by means of mixed anhydride and its application to large-ring lactonization.
- Use of 1,8-diazabicyclo(5.4.0)undec-7-ene in preparation of trimethylsilyl enol ethers and trimethylsilylacetylenes.
- Synthesis of thiol esters by carboxylic trichlorobenzoic anhydrides.
- Synthesis of macrocyclic (n.n.n)(1,3,5)cyclophane polylactones.
- Esterification of carboxylic acids by alcohols with 2-chloro-1,3,5-trinitrobenzene as condensing agent.
- Immunohistochemical Localization of Relaxin and Its Receptors in Salivary Gland Tumors: A Preliminary Analysis
- Stereoselective construction of acyclic structures with four consecutive asymmetric centers.
- Asymmetric Diels-Alder reaction of acrylamides having trans-2,5-disubstituted pyrrolidines as chiral auxiliaries.
- Diastereoselective reduction of .ALPHA.-keto amides having trans-2,5-disubstituted pyrrolidine as a chiral auxiliary.
- The Structure of Ternstroemiaxanthin, a New Aldehydic C40-Carotenoid
- Preparation of hindered esters from acid chlorides and alcohols in the presence of silver cyanide.
- Synthesis of Bis(2,4,5-trimethylphenyl)-, Bis(2,4,6-trimethylphenyl)-, and Bis(3,4,5-trimethylphenyl)tetramethyloctadecanonaene
- Total Synthesis of Natural Acetylenic Analogues of Isorenieratene and Renieratene
- Two Natural Acetylenic Aromatic Carotenoids
- 4-Dimethylaminopyridine N-oxide as an efficient oxidizing agent for alkyl halides.
- The stereoselective synthesis of threo-3-hydroxy-4-amino acids.
- Phosphorylation of nucleosides with sodium cyclo-triphosphate.
- Influences of Long-term Tolbutamide Administration on Diabetic Syndrome in Alloxan Rabbits
- Histopathological Studies in Long-term Tolbutamide-administered Alloxan Diabetes Rabbits
- Studies on Electro-retinogram in Alloxan Rats and Mongolian Gerbils (Meriones Unguiculatus) and Influences of Long-term Tolbutamide Administration
- Hypoglycemic actions of disopyramide enantiomers as bitartrate salts.
- Studies on the mechanism of disopyramide-induced hypoglycemia.
- Application of gel chromatography to the determination of the stability constants of a magnesium complex with diphosphate.
- Spectrophotometric determination of silicic acid by flow injection analysis.
- The reaction of cyclo-tetraphosphate with L-valine.
- Thermal Decomposition of Uranyl Dihydrogen Orthophosphate Trihydrate
- TOXICITY OF MESOXALATES AND HISTOLOGICAL OBSERVATIONS AFTER CONTINUOUS ADMINISTRATION
- EFFECT OF THE SALTS OF MESO-OXALIC ACID ON ALLOXAN DIABETES MELLITUS
- MECHANISM OF ANTI-DIABETIC ACTIVITY OF CALCIUM MESOXALATE
- The pH Dependence of Anion Exchange Chromatographic Separation of Tri- and Tetraphosphate Anions