MECHANISM OF ANTI-DIABETIC ACTIVITY OF CALCIUM MESOXALATE
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概要
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In a previous paper [Kobayashi, Ohashi and Takeuchi (1)] we reported that when calcium or sodium salt of mesoxalic acid was administered to dogs and rabbits made diabetic with alloxan, the sugar content of their urine either was reduced or dropped to zero and their blood sugar level fell. Further, if the animals were more severely afflicted, ketone bodies in the blood and the NPN of the urine also decreased. It was reported that none of these effects of mesoxalate was visible in depancreatized dogs. It seems obvious, therefore, that the activity of mesoxalates on alloxan diabetic animals is closely related to the function of the pancreas. Herein is reported a series of experiments conducted to clarify the mechanism of action of the compounds.
- 公益社団法人 日本薬理学会の論文
著者
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Takeuchi Setsuya
Department Of Pharmacology Nippon Medical School
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Ohashi Shigeru
Department of Chemistry Faculty of Science Kanazawa University
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KOBAYASHI YOSHITO
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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- The reaction of cyclo-tetraphosphate with L-valine.
- Thermal Decomposition of Uranyl Dihydrogen Orthophosphate Trihydrate
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- EFFECT OF THE SALTS OF MESO-OXALIC ACID ON ALLOXAN DIABETES MELLITUS
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