Studies on Electro-retinogram in Alloxan Rats and Mongolian Gerbils (<I>Meriones Unguiculatus</I>) and Influences of Long-term Tolbutamide Administration
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概要
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Electro-retinogram in alloxan rats showed attenuation in the amplitudes of waves and significant attenuation or abolishment of oscillatory wavelet in agree ment with the findings for diabetes mellitus. Prolonged administration of tolbu tamide increased the wave amplitude of ERG for alloxan rats but failed to abolish oscillatory wavelet, a characteristic syndrome of diabetes. And the treatment of normal rats increased both the a-and the a+b wave amplitudes without changing the wave configuration of ERG. It is, thus, considered that the increase in the wave amplitude of ERG may not be an indirect effect of long term administration of tolbutamide through the improvement of diabetic process itself but rather its direct action on retinal cells. In mongolian gerbils (<I>Meriones unguiculatus</I>), the ERG did not show any changes which might be due to diabetic process as men tioned in the experiment on alloxan diabetes rats.
- 一般社団法人 日本臨床薬理学会の論文
著者
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Fujie Kyo
Department Of Pharmacology Yokohama City University School Of Medicine
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NAKAMA KAZUMASA
Department of Pharmacology, Nippon Medical School
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Okamura Tadao
Department Of Pharmacology Nippon Medical School
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Takeuchi Setsuya
Department Of Pharmacology Nippon Medical School
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OKAMOTO Kou
Department of Pharmacology, School of Medicine, Yokohama City University
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FUJIE Yo
Department of Pharmacology, School of Medicine, Yokohama City University
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FUJIE Kyo
Department of Pharmacology, School of Medicine, Yokohama City University
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