Influences of Long-term Tolbutamide Administration on Diabetic Syndrome in Alloxan Rabbits

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The present experiments were designed to study the effects of prolonged tolbu-tamide (Tolb) administration on diabetic symptoms, using alloxan rabbits as model. Eighty seven diabetic rabbits obtained by the intravenous injection of 100-130mg/kg of alloxan monohydrate were divided into three groups-untreated control, Tolb 100 mg/kg treated group and Tolb 200mg/kg treated group. Tolb was given consecutively for 3 and 6 months, and during these periods, body weight, morning blood glucose and the daily amount of urinary sugar were measured. And also ECG recording, PSP excretion test and ophtalmologic test were performed. During the 6 months period, body weight tended to increase and blood glucose and urinary sugar tended to diminish gradually, but there was no difference in death rate among the three groups.<BR>As for ECG, bradycardia and abnormal ST-T were observed in several alloxanized rabbits, and in the Tolb treated groups their incidences were significantly increased. As for PSP test, no abnormal values were obtained from the alloxanized animals, and also no effect of Tolb was found.<BR>The longer the expeimental course, the number of incidence of cataract was found to become higher. But neither retinal vessel alteration nor other pathological changes were observed in the alloxan animals, with no difference observed between the control and the treated group.
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