Genetic Approaches to the Molecular/Neuronal Mechanisms Underlying Learning and Memory in the Mouse
スポンサーリンク
概要
- 論文の詳細を見る
Learning and memory is an essential component of human intelligence. To understand its underlying molecular and neuronal mechanisms is currently an extensive focus in the field of cognitive neuroscience. We have employed advanced mouse genetic approaches to analyze the molecular and neuronal bases for learning and memory, and our results showed that brain region-specific genetic manipulations (including transgenic and knockout), inducible/reversible knockout, genetic/chemical kinase inactivation, and neuronal-based genetic approach are very powerful tools for studying the involvements of various molecules or neuronal substrates in the processes of learning and memory. Studies using these techniques may eventually lead to the understanding of how new information is acquired and how learned information is memorized in the brain.
- 社団法人 日本薬理学会の論文
- 2005-09-20
著者
-
Nakajima Akira
Department Of Psychiatry Committee On Neurobiology The University Of Chicago Knapp Medical Research
-
Tang Ya-ping
Department Of Psychiatry Committee On Neurobiology The University Of Chicago Knapp Medical Research
-
Nakajima Akira
Department Of Applied Electronics Tokyo Institute Of Technology
関連論文
- A Proposal of a Novel RFID Tag with Biomedical Signal Sensing Functions
- CLINICAL FEATURES OF JAPANESE LEBER'S HEREDITARY OPTIC NEUROPATHY WITH 11778 MUTATION OF MITOCHONDRIAL DNA
- Droplet Size Dependence of Line Tension for an Ionic Liquid on a Smooth Silane Coating
- INTERCALATION BEHAVIOR OF VARIOUS FATTY ACIDS INTO Mg-Al-LAYERED DOUBLE HYDROXIDE
- Preparation of Pt particles dispersing nanocomposites by thermal treatment of tetrachloroplatinate/layered double hydroxide (LDH)
- Effect of Liquid Viscosity on the Internal Fluidity of a Droplet Sliding on a Fluoroalkylsilane Coating
- Voltage swing interval effects on photocatalytic decomposition of 1, 4-dioxane in aqueous media using TiO_2-coated stainless mesh( Innovative Ceramic Materials and Technologies for Global Environmental Protection)
- Slipping and Rolling Ratio of Sliding Acceleration for a Water Droplet Sliding on Fluoroalkylsilane Coatings of Different Roughness
- Effect of Electrification Conditions on the Freezing of Supercooled Water Droplets on a Hydrophobic Coating
- Effects of Vacuum Ultraviolet Light Illumination on the Residual Stress in Sol-Gel-derived Titanium Dioxide Films
- Effect of Roughness on Lipophobicity of a Surface Prepared Using Boehmite Nanoparticles and Fluoroalkylsilane
- Sliding Mode Transition of Water Droplet on the Silicon Surface Coated with Octadecyltrichlorosilane
- Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice
- Phytotoxicity of Indole-3-acetic Acid Produced by the Fungus, Pythium aphanidermatum
- A Novel Diol-derivative of Chalcone Produced by Bioconversion, 3-(2,3-Dihydroxyphenyl)-1-phenylpropan-1-one, Activates Phosphorylation of ERK and CREB in Cultured Rat Cortical Neurons
- High-Level Fluoroquinolone Resistance in Pseudomonas aeruginosa Due to Interplay of the MexAB-OprM Efflux Pump and the DNA Gyrase Mutation
- Development of Three-dimensional FE Modeling System from the Limited Cone Beam CT Images for Orthodontic Tipping Tooth Movement
- Uptake of Uranium from Sea Water by Microalgae : Studies on the Accumulation of Heavy Metal Elements in Biological Systems (VI)
- S9-6 Effects of tumor necrosis factor-α and glial cell lined-neurotrophic factor on the toxicity-induced by methamphetamine in vivo and in vitro(SYMPOSIUM 9: MOLECULAR MECHANISMS OF DRUG DEPENDENCE)(Proceedings of the 31st Annual Meeting)
- High Density Two-Dimensional Hole Gas Induced by Negative Polarization at GaN/AlGaN Heterointerface
- Freezing Behavior of a Water Droplet on a Rough Hydrophobic Surface Coated with a Short-chained Fluoroalkylsilane
- Negative Line Tension for an Ionic Liquid on a Hydrophobic Fluoroalkylsilane Coating
- Honeybee Royal Jelly Stimulates CRE-mediated Transcription in a PKA- but Not MEK/ERK-dependent Manner in PC12D Cells
- 1/f Fluctuations in the Dielectric Response of Triglycine Sulfate : Thermal and Statistical Properties
- Genetic Approaches to the Molecular/Neuronal Mechanisms Underlying Learning and Memory in the Mouse
- Effect of Mechanical Deformation on Permeation of Hydrogen in Iron
- Effect of Sulbactam on Anti-Pseudomonal Activity of β-Lactam Antibiotics in Cells Producing Various Levels of the MexAB-OprM Efflux Pump and β-Lactamase
- Effect of Acetic Acid and Vinegar on Blood Glucose and Insulin Responses to Orally Administered Sucrose and Starch(Food & Nutrition)
- Biomechanical influences on the upper vertebrae during mastication, an examination using the finite element method
- Mechanism of Gold Adsorption by Persimmon Tannin Gel
- Adsorption of Uranium by Vegetable Crude Drugs(Biological Chemistry)
- Biological and Immunological Characterization of Human Luteinizing Hormone Discharged in a Pulsatile Fashion in the Normal Menstrual Cycle
- Biological and Immunological Characterization of Human Luteinizing Hormone Discharged by the Stimulation of Synthetic Luteinizing Hormone-Releasing Hormone (LH-RH) in Normal and Anovulatory Women
- A Trial for the Improvement of the in vitro Bioassay for Human Luteinizing Hormone
- Measurements of Human Luteinizing Hormone in Plasma by in vitro Bioassay and by Conventional and Improved Radioimmunoassays
- Preparative Studies of ZnO Varistors I. : Effect of Calcination on the V-I Characteristics of ZnO Varistors
- HDI-26 THE EVAPORATION AND READSORPTION OF LUBRICANT FILM MOLECULES IN HARD DISKS
- A convenient controlling apparatus simply realized with inexpensiveelectronic parts and its application to the temperature dependences of electroceramicmaterials
- Control of static and dynamic hydrophobicity of solid surface and its application
- Possible Applications of Electrophysiology in Ophthalmic Clinics(SYMPOSIUM ON ELECTRORETINOGRAPHY)
- A Preliminary Study of Some Ion-conductive Mixtures
- Shear Stress Analysis of EHL Oil Films Based on Thermal EHL Theory - Effect of Inlet Oil Temperature -
- Wetting Mode Transition of Water Droplets by Electrowetting on Highly Hydrophobic Surfaces Coated with Two Different Silanes
- SF6-Based Deep Reactive Ion Etching of (001) Rutile TiO2 Substrate for Photonic Crystal Structure with Wide Complete Photonic Band Gap
- Growth of Low-Dislocation-Density AlN under Ga Irradiation
- Studies on Luminescence Characteristics of Fine Semiconductor Particles in Glasses and Ceramics I. : Effect of Oxidation on the Luminescent Properties of Small Semiconductor Grains in Silicic Media
- Bronchial Schwannoma Masquerading as Cause of Hemoptysis in a Patient with Pulmonary Embolism
- Pott's Disease and Cold Abscesses
- Accumulation of Uranium by Chlorella Cells Grown under Autotrophic, Heterotrophic and Mixotrophic Culture Conditions
- Influences of Long-term Tolbutamide Administration on Diabetic Syndrome in Alloxan Rabbits
- Sliding Tribological Behaviors of Cu and Fe against Si3N4 under Electrolysis
- Preparative Studies of ZnO Varistors II. : Additive Effects of Some Metallic Oxides on the V-I Characteristics of ZnO Varistor Devices
- Dipolar Interaction in TEMPAD Biradical
- Studies of Ceramic Gas Sensors : Effects of Various Oxide Additives
- Pott's Disease and Cold Abscesses
- Study of Zinc Oxide Varistors with Relation to the Mode of Preparation andAddition of Transition Metal Oxides
- Magnetic Properties of Some Iminoxyl Polyradicals. II. TEMPOP Triradical and TEMPOS Tetraradical
- CD47 regulates the TGF-.BETA. signaling pathway in osteoblasts and is distributed in Meckel's cartilage