Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice
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概要
- 論文の詳細を見る
We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer’s disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice.
- 社団法人 日本薬理学会の論文
- 2007-09-20
著者
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NAKAJIMA Akira
Department of Computer Science and Electrical Engineering, Graduate School of Science and Technology
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NAKAGAWASAI Osamu
Department of Pharmacology, Tohoku Pharmaceutical University
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Tadano Takeshi
Department Of Pharmacology Tohoku Pharmaceutical University
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OHIZUMI Yasushi
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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Tadano Takeshi
Department Of Pharmacology Tohoku College Of Pharmacy
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三巻 祥浩
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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YAMAKUNI TOHRU
Departments of Neuropharmacology, Brain Research Institute, Niigata University
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Song Si-young
Institute Of Neuroscience Tokushima Bunri University At Kagawa
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Yamakuni Tohru
Tohoku Univ. Sendai Jpn
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Yamakuni Tohru
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Science Tohoku Univ
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Yokosuka Akihito
Lab. Of Medicinal Pharmacognosy School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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MIMAKI Yoshihiro
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Sci
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SASHIDA Yutaka
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Sci
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Yokosuka Akihito
Laboratory of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sci
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HARAGUCHI Mitsuya
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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OMAE Naoki
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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KATO Chieko
Institute of Neuroscience, Tokushima Bunri University at Kagawa
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Oshima Yasukatsu
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Mimaki Yoshihiro
Lab. Of Medicinal Plant Sci. School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sci. Jpn
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Mimaki Yoshihiro
Laboratory Of Medical Plant Science Tokyo University Of Pharmacy And Life Science
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Nakagawasai Osamu
Department Of Pharmacology Tohoku Pharmaceutical University
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Nakajima Akira
Department Of Pharmacotherapy Graduate School Of Pharmaceutical Sciences Tohoku University
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Omae Naoki
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Kato Chieko
Institute Of Neuroscience Tokushima Bunri University At Kagawa
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Kato Chieko
Institute Of Neuroscience Tokushima Bunri University
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Sashida Y
Laboratory Of Medicinal Plant Science School Of Pharmacy Tokyo University Of Pharmacy And Life Scien
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Sashida Yutaka
Laboratory Of Medical Plant Science Tokyo University Of Pharmacy And Life Science
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Sashida Yutaka
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Mimaki Yoshihiro
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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Nakajima Akira
Department Of Applied Electronics Tokyo Institute Of Technology
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Ohizumi Yasushi
Univ. Shizuoka Shizuoka Jpn
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Yokosuka Akihito
Laboratory Of Medicinal Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Scien
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Yokosuka Akihito
Laboratory Of Medicinal Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Scien
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Haraguchi Mitsuya
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Ohizumi Yasushi
Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Sashida Yutaka
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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TADANO Takeshi
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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