Executive Functions of Postweaning Protein Malnutrition in Mice
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概要
- 論文の詳細を見る
It is well known that nutritional status during the fetal and/or lactation period is important for the development of the central nervous system (CNS). In contrast, the effect of malnutrition on postweaning development has not yet been thoroughly investigated. In the present study, we analyzed the behavioral and neuroanatomical effects of protein malnutrition (PM) postweaning in mice. Starting at 20—21 d of age, male ddY mice were maintained on a 5% casein diet (PM group) or 20% casein diet (control group) for 20 d. On the 20th d, body and brain weights of PM mice were lower than those of the control group. PM mice exhibited excessive alertness and spontaneous activity under novel conditions in the Irwin test. In addition, PM mice showed increased open arm exploration in the elevated plus maze compared to control mice. These results suggest that hyperactivity and reduced anxiety behavior or higher impulsiveness in PM mice could be due to an immature brain.
著者
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NIIJIMA Fukie
Department of Pharmacology, Tohoku Pharmaceutical University
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TADANO Takeshi
Department of Pharmacology, Tohoku Pharmaceutical University
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Tan-no Koichi
東北薬科大学 薬理学
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Tan-no Koichi
東北薬科大学 薬理
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Tan-no Koichi
Department Of Pharmacology Tohoku College Of Pharmacy
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Tan‐no K
Dep. Of Pharmacology Tohoku Pharmaceutical Univ.
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Tan-no Koichi
東北大学 医系研究 分子薬理
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Tadano Takeshi
Department Of Pharmacology Tohoku College Of Pharmacy
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Nakagawasai Osamu
Department Of Pharmacology Tohoku Pharmaceutical University
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Sato Shoko
Department Of General Internal Medicine The Jikei University School Of Medicine
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Suzuki Tsuneyoshi
Department of Pharmaceutical Sciences, Tohoku Pharmaceutical University
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Suzuki Tsuneyoshi
Department of Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka
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TADANO Takeshi
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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Sato Shoko
Department of Pharmaceutical Sciences, Tohoku Pharmaceutical University
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