Effect of a Nutritive-Tonic Drink on Scopolamine-Induced Memory Impairment in Mice(Pharmacology)

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概要

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• The effects of a liquid nutritive and tonic drug (NTD) selected from a modification of the "Kai-xin-shou-yu-shen-qi-wan" prescription, on scopolamine-induced amnesia in mice were investigated using the passive avoidance and water-maze tasks. A popular NTD in Japan that contains 17 crude (natural) drug extracts together with synthetic drugs such as taurine, caffeine, various vitamins and ethanol, and the natural drug extracts is based on a prescription of "Kampo" origin in Chinese medicine. Scopolamine (0.4mg/kg, i.p.) reduces the stepthrough latency of the passive avoidance test and fear reaction behavior at 24 and 48h after treatment. A single oral administration of the NTD (10ml/kg) increased the step-through latency and the fear reaction behavior score in scopolamine-treated mice. Administration of the natural drug extracts found in the NTD tended to extend the step-through latency in the retention test at 48h, but not 24h after the initial scopolamine trial. However, administration of the synthetic drugs found in the NTD did not improve either the step-through latency or the behavioral score. The NTD and the natural drug extracts also improved the scopolamine-induced spatial memory impairment as assessed using the Morris water-maze test. In contrast, the synthetic drugs did not affect the escape latencies. Both NTD and the synthetic drugs increased the locomotor activity in scopolamine-treated mice, whereas the natural drug extracts did not. These results suggest that NTD improves scopolamine-induced amnesia, and that this action is attributable to the natural drug extracts in the NTD.

• 社団法人日本薬学会の論文
• 2005-10-01

著者

• TADANO Takeshi

  Department of Pharmacology, Tohoku Pharmaceutical University

• Ito Yoshihisa

  Department of Labolatory Medicine, Asahikawa Medical College

• Tadano Takeshi

  Department Of Pharmacology Tohoku Pharmaceutical University

• Ishige Kumiko

  Department Of Pharmacology College Of Pharmacy Nihon University

• Tadano Takeshi

  Department Of Pharmacology Tohoku College Of Pharmacy

• SAKATA Yasuko

  Department of Pharmacology, College of Pharmacy, Nihon University

• CHIDA Rie

  Department of Pharmacology, College of Pharmacy, Nihon University

• EDAGAWA Yoshikuni

  Department of Pharmacology, College of Pharmacy, Nihon University

• Ito Yoshihisa

  日本大学 薬学部医療薬学系薬理学ユニット

• Chida Rie

  Department Of Pharmacology College Of Pharmacy Nihon University

• Edagawa Yoshikuni

  Department Of Pharmacology College Of Pharmacy Nihon University

• Ito Yoshihisa

  Department Of Internal Medicine First Division School Of Medicine Kobe University

• Sakata Yasuko

  Department Of Pharmacology College Of Pharmacy Nihon University

• TADANO Takeshi

  Department of Chemical Pharmacology, Tohoku College of Pharmacy

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