Roles of γ-Aminobutyric Acid_B (GABA_B) and γ-Hydroxybutyric Acid Receptors in Hippocampal Long-Term Potentiation and Pathogenesis of Absence Seizures
スポンサーリンク
概要
- 論文の詳細を見る
Experiments were performed to examine the roles of γ-aminobutyric acid_B (GABA_B) and γ-hydroxybutyric acid (GHB) receptors in long-term potentiation (LTP) of the hippocampal CA1 region in vivo and in the genesis of the spike and wave discharges (SWDs) associated with absence seizures. When tetanic stimulation was delivered to the CA3 region, stable LTP was observed in the CA1 region in saline-treated mice. In mice treated with 5 mg/kg baclofen, the population spike amplitude was significantly potentiated by tetanic stimulation and the degree of potentiation was the same as that induced in saline controls. However, this potentiation decayed to the baseline level about 90 min after stimulation. The decay was reversed by pretreatment with 200 mg/kg P-[3-aminopropyl]-P-diethoxymethylphosphinic acid (CGP 35348), a selective GABA_B receptor antagonist. In mice treated with 50 mg/kg γ-butyrolactone (GBL), a prodrug of GHB, stable LTP was observed 90 min after tetanic stimulation and was greater than that in saline controls. GBL-induced potentiation of LTP was antagonized by 50 mg/kg NCS 382,a putative GHB receptor antagonist. Administration of baclofen (20 mg/kg) or GBL (70 mg/kg) induced absence-like seizures associated with 3-6 Hz SWDs, and CGP 35348 suppressed both baclofen- and GBL-induced SWDs. NCS 382 also attenuated SWDs induced by GBL and baclofen. These results suggest that baclofen and GHB have different effects on LTP in the CA1 region of the hippocampus in vivo, although they have a common mode of action on the thalamocortical functions related to the pathogenesis of absence seizures.
- 公益社団法人日本薬学会の論文
- 1997-10-15
著者
-
Ito Yoshihisa
Department of Labolatory Medicine, Asahikawa Medical College
-
FUKUDA Hideomi
Department of Pharmacology, College of Pharmacy, Nihon University
-
Ito Yoshihisa
Department Of Pharmacology College Of Pharmacy Nihon University
-
Fukuda H
Department Of Pharmacology College Of Pharmacy Nihon University
-
Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
-
Ito Yoshihisa
Department Of Internal Medicine First Division School Of Medicine Kobe University
-
Fukuda H
Chiba Univ.
-
AIZAWA Masahiro
Department of Pharmacology, College of Pharmacy, Nihon University
-
Aizawa Masahiro
Department Of Pharmacology College Of Pharmacy Nihon University
-
FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
関連論文
- Clinical Detection of Heat Shock Protein 72 Expression and Cardiac Function in Acute Myocardial Infarction
- THE ROLE OF SYMPATHETIC ACTIVITY IN HYPERTENSIVE MECHANISM OF BRADYKININ : Hypertension : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- A PROTECTIVE EFFECT OF VERAPAMIL AND INTRACELLULAR CALCIUM IN HYPOXIC HEART MUSCLE : Cardiovascular Drugs : IV Auditorium : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- CARDIOVASCULAR RESPONSE AND TISSUE CYCLIC NUCLEOTIDE LEVELS : Pulmonary Circulation, Peripheral Circulation : IVth Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- Effect of a Nutritive-Tonic Drink on Scopolamine-Induced Memory Impairment in Mice(Pharmacology)
- EFFECT OF THYROID HORMONE ON MYOCARDIAL CONTRACTILITY AND SUBCELLULAR DISTRIBUTION OF CALCIUM IN RABBITS : Myocardial metabolism . Biochemistry : 46th Annual Scientific Meeting, Japanese Circulation Society
- RELATIONSHIP BETWEEN PLASMA PROLACTIN CONCENTRATION AND SYMPATHETIC ACTIVITY IN MALES WITH BORDERLINE HYPERTENSION, AND THE ROLE OF PROLACTIN IN CARDIOVASCULAR SYSTEM : Kidney・Hypertension : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, J
- S5-5 Potentiation of NMDA agonist-induced neuronal death by β-amyloid in rat organotypic hippocampal slice cultures : evidence for multiple cell death pathways(SYMPOSIUM 5: PHYSIOLOGY AND DISEASE OF GLUTAMATE IN NEURONAL AND GLIAL CELLS)(Proceedings of th
- N-acetylcysteine selectively protects cerebellar granule cells from 4-hydroxynonenal-induced cell death
- Modulation of Voltage-Gated Ca^ Current by 4-Hydroxynonenal in Dentate Granule Cells(Highlighted paper setected by Editor-in-cfiief)(Pharmacology)
- Protective effect of S-allyl-L-cysteine, a garlic compound, on amyloid β-protein-induced cell death in nerve growth factor-differentiated PC12 cells
- Morphine augments excitatory synaptic transmission in the dentate gyrus through GABAergic disinhibition
- Comparative study of survival signal withdrawal- and 4-hydroxynonenal-induced cell death in cerebellar granule cells
- EFFECTS OF VALPROIC ACID ON SPINAL REFLEXES AND [^3H]MUSCIMOL AND [^3H]DIAZEPAM BINDING IN BRAIN MEMBRANES IN RATS
- IMPAIRMENT OF VISUAL SYSTEM OF BEAGLES ORALLY INGESTING CLIOQUINOL
- DETERIORATION OF SPINAL REFLEX IN BEAGLES ORALLY INGESTING CLIOQUINOL
- Comparison of C-reactive Protein Levels between Serum and Plasma Samples on Long-term Frozen Storage after a 13.8 Year Interval : The JMS Cohort Study
- CENTRALLY SPECIFIC AND GABA-INSENSITIVE INHIBITION OF BENZODIAZEPINE BINDING BY PROSTAGLANDINS (A_1,A_2 AND B_2)
- γ-AMINOBUTYRIC ACID AND BENZODIAZEPINE RECEPTOR INTERACTION
- EFFECTS OF BARBITURATES ON THE DECEREBRATE RIGIDIIY IN RATS
- QT PRODACT : Evaluation of the Potential of Compounds to Cause QT Interval Prolongation by Action Potential Assays Using Guinea-Pig Papillary Muscles
- QT PRODACT : A Multi-site Study of In Vitro Action Potential Assays on 21 Compounds in Isolated Guinea-Pig Papillary Muscles
- Evaluation of Distribution Patterns for Copper and Zinc in Metallothionein and Superoxide Dismutase in Chronic Liver Diseases and Hepatocellular Carcinoma Using High-Performance Liquid Chromatography(HPLC)(Analytical Biochemistry)
- Natural drug extracts for a nutritive-tonic drink, promotes the induction of long-term potentiation in rat hippocampal dentate gyrus in vivo
- Structure-Activity Relationships of Phenylethylamine Analogs in Their Serotonergic Depressant Effects on the Spinal Monosynaptic Reflex in Rats
- Enhancement of Spinal Monosynaptic Reflexes with Phenylethylamine and Related Drugs through Descending Noradrenergic Neurons
- Immunohistochemical metallothionein expression in hepatocellular carcinoma : relation to tumor progression and chemoresistance to platinum agents
- Roles of γ-Aminobutyric Acid_B (GABA_B) and γ-Hydroxybutyric Acid Receptors in Hippocampal Long-Term Potentiation and Pathogenesis of Absence Seizures
- Pharmacological profiles of generalized absence seizures in lethargic, stargazer and γ-hydroxybutyrate-treated model mice
- PHARMACOLOGICAL EVALUATION OF GARENOXACIN, A NOVEL DES-F(6)-QUINOLONE ANTIMICROBIAL AGENT : EFFECTS ON THE CENTRAL NERVOUS SYSTEM
- EFFECT OF NMDA RECEPTOR ANTAGONISTS ON PROTEIN KINASE ACTIVATED BY CHRONIC MORPHINE TREATMENT
- INHIBITORY EFFECT OF THE NMDA RECEPTOR ANTAGONIST, DIZOCILPINE (MK-801), ON THE DEVELOPMENT OF MORPHINE DEPENDENCE
- SPINAL REFLEXES IN CHINOFORM-ADMINISTERED RATS
- SPINAL REFLEXES IN RATS SUFFERED FROM MOTOR INCOORDINATION BY CHINOFORM
- Measurement of Acoustic Property Distributions of Diseased Heart and Liver Tissues
- The Tissue Catecholamine Concentration of the Rabbit in Experimental Cardiac Failure
- Effects of quinolone antibacterial agents and related compounds on GABA_A receptor chloride ion channels.
- β_1-Adrenergic receptor mediation in the lichen glucan PB-2-induced enhancement of long-term potentiation in the rat dentate gyrus in vivo
- DETERIORATION OF SPINAL REFLEX IN QUAILS ORALLY INGESTING CLIOQUINOL
- An Improved Diagnostic Method for Chronic Hepatic Disorder : Analyses of Metallothionein Isoforms and Trace Metals in the Liver of Patients with Hepatocellular Carcinoma as Determined by Capillary Zone Electrophoresis and Inductively Coupled Plasma-Mass S
- The copper/zinc ratio in patients with hepatocellular carcinoma
- A New Diagnostic Method for Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma Based on Serum Metallothionein,Copper, and Zinc Levels
- Extraction of Quantitative Three-Dimensional Information from Ultrasonic Volumetric Images of Cirrhotic Liver
- EFFECTS OF METABOLIC INHIBITORS AND OUABAIN ON STATIC AFFERENT DISCHARGES FROM THE ISOLATED FROG MUSCLE SPINDLE
- EFFECTS OF CENTRALLY ACTING MUSCLE RELAXANTS ON THE ANEMIC DECEREBRATE RIGIDITY IN RATS
- EFFECT OF BACLOFEN ON THE γ-MOTOR ACTIVITY IN THE RAT
- MODE OF ACTION OF L-DOPA ON γ-MOTOR SYSTEM IN THE RAT
- Catecholamine in Congestive Heart Failure : Report II
- ANTICONVULSANT ACTION OF DIAZEPAM IN MICE PRETREATED WITH CAFFEINE
- Analyses of the Metallothioneins and Trace Metals in the Liver and Serum of the Patients with Hepatocellular Carcinoma
- POSTNATAL DEVELOPMENT OF THE BENZODIAZEPINE AND GABA RECEPTORS IN THE RAT SPINAL CORD
- POSTNATAL DEVELOPMENT OF THE GABA SYSTEM IN THE RAT SPINAL CORD
- EFFECTS OF ANTICHOLINERGICS ON THE AFFERENT DISCHARGES FROM THE MUSCLE SPINDLE OF THE BULLFROG IN VITRO
- EFFECTS OF ZOPICLONE AND BENZODIAZEPINES ON SPINAL REFLEXES, ANEMIC DECEREBRATE RIGIDITY AND BENZODIAZEPINE BINDING
- Muscle relaxation mediated by central alpha_2-agonistic action in decerebrate rigidity in rats
- PHARMACOLOGICAL EVALUATION OF MUSCLE RELAXANTS
- DECREASE IN EFFECTS OF MUSCIMOL ON THE DORSAL ROOT AFTER REPEATED ADMINISTRATION OF DIAZEPAM IN RATS
- MECHANISMS OF DEPRESSANT ACTION OF MUSCLE RELAXANTS ON SPINAL REFLEXES : PARTICIPATION OF MEMBRANE STABILIZING ACTION
- EXCITATION BY LYONIOL-A OF VAGAL AFFERENT NERVES AND THE REFLEX AUTONOMIC AND SOMATIC ACTIONS IN RATS
- EFFECTS OF EXCITATORY TRANSMITTER CANDIDATES ON FROG SPINAL MOTOR FUNCTION
- ALTERATIONS IN SPONTANEOUS ACTIVITY OF THE ISOLATED FROG SPINAL CORD IN CALCIUM-FREE ENVIRONMENT
- ALTERATION OF EXTRACELLULAR K+-ACTIVITY INDUCED BY AMINO ACIDS IN THE FROG SPINAL CORD
- RIGIDITY IN RATS DUE TO ANEMIC DECEREBRATION AND THE EFFECT OF CHLORPROMAZINE
- EFFECT OF LYONIOL-A ON DECEREBRATE RIGIDITY AND ELECTROENCEPHALOGRAM IN RATS
- SPONTANEOUS ELECTRICAL ACTIVITY OF THE BULLFROG SPINAL CORD AND SUSCEPTIBILITY TO SOME CENTRALLY ACTING DRUGS AND AMINO ACIDS
- The role of parasympathetic nerve activity in the pathogenesis of coronary vasospasm.
- Amphetamine-Antagonistic Property of 4-Phenyltetrahydroisoquinoline: Effect on Noradrenaline Release in Spinal Cord Slices.
- 2-Phenylethylamine and methamphetamine enhance the spinal monosynaptic reflex by releasing noradrenaline from the terminals of descending fibers.
- Effects of pentobarbital on (3H)diazepam binding in the cerebral cortex, cerebellum and spinal cord of developing rats.
- Effect of the Centrally Acting Muscle Relaxant Tizanidine on Spinal Reflexes: Involvement of Descending Noradrenergic Systems.
- Spinal .ALPHA.1- and .ALPHA.2-adrenoceptors mediate facilitation and inhibition of spinal motor transmission, respectively.