DECREASE IN EFFECTS OF MUSCIMOL ON THE DORSAL ROOT AFTER REPEATED ADMINISTRATION OF DIAZEPAM IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
In in situ experiments on spinal rats transected at the C1 level and on non-spinal rats, muscimol (3 mg/kg, i.v.) depolarized the primary afferent fibers and diazepam (3 mg/kg, i.v.) potentiated this effect of muscimol. When diazepam was given for 14 days, the effect of muscimol was significantly reduced in non-spinal, but not in spinal rats. These findings suggest that diazepam probably interacts with GABA-ergic mechanisms more closely in supraspinal regions of the rat.
- 公益社団法人日本薬学会の論文
著者
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Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
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Kaneko Tsugio
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Ono Hideki
Department Of Cardiology Ninon University Surugadai Hospital
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FUKUDA Hideomi
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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