ANTICONVULSANT ACTION OF DIAZEPAM IN MICE PRETREATED WITH CAFFEINE
スポンサーリンク
概要
- 論文の詳細を見る
Anticonvulsant activities of diazepam in mice given pentylenetetrazol (PTZ), as well as effects of diazepam against potentiating activities of caffeine on these convulsions, were studied. Electroencephalographic (EEG) and electromyographic (EMG) recordings and behavioral observations were employed. First spike, clonic and tonic convulsions induced by PTZ were readily recognized from the EEF recording coupled with EMG recording. Pretreatment of mice with diazepam suppressed the incidence of clonic and tonic convulsions, but did not affect the development of first spike. These anticonvulsive effects of diazepam were also observed when PTZ-induced convulsions were potentiated with caffeine, except for clonic convulsion which was not suppressed with diazepam. The mechanisms of the antagonistic effects between diazepam and caffeine are discussed.
- 公益社団法人日本薬学会の論文
著者
-
Goto Masayoshi
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
-
Fukuda Hideomi
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
-
Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
-
Morishita Shin-ichi
Department Of Computational Biology Graduate School Of Frontier Science University Of Tokyo
-
Goto Masayoshi
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
-
Morishita Shin-ichi
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
-
FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
-
GOTO Masayoshi
Department of Biological Science, Research and Development Laboratories, Hoechst Japan Limited
関連論文
- Comparative study of survival signal withdrawal- and 4-hydroxynonenal-induced cell death in cerebellar granule cells
- MEDAKA GENOME SEQUENCING AND THE VERTEBRATE GENOME EVOLUTION(Genetics,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Draft Genome Sequence of Medaka (Orizias latipes) and Its Useful Applications(A Synthesis of the Molecular Phylogeny and the Comparative Genomics in Fishes,Symposium,PROCEEDING OF THE 76^ ANNUAL MEETING OF THE ZOOLOGICAL SOCIETY OF JAPAN)
- Medaka Genome Sequencing and the Comparative Genomics of Fishes(Comparative Genomics of Animals,Symposium,PROCEEDING OF THE 76^ ANNUAL MEETING OF THE ZOOLOGICAL SOCIETY OF JAPAN)
- EFFECTS OF VALPROIC ACID ON SPINAL REFLEXES AND [^3H]MUSCIMOL AND [^3H]DIAZEPAM BINDING IN BRAIN MEMBRANES IN RATS
- IMPAIRMENT OF VISUAL SYSTEM OF BEAGLES ORALLY INGESTING CLIOQUINOL
- DETERIORATION OF SPINAL REFLEX IN BEAGLES ORALLY INGESTING CLIOQUINOL
- DETERIORATION OF SPINAL REFLEX IN BEAGLES ORALLY INGESTING CHINOFORM
- CENTRALLY SPECIFIC AND GABA-INSENSITIVE INHIBITION OF BENZODIAZEPINE BINDING BY PROSTAGLANDINS (A_1,A_2 AND B_2)
- γ-AMINOBUTYRIC ACID AND BENZODIAZEPINE RECEPTOR INTERACTION
- EFFECTS OF BARBITURATES ON THE DECEREBRATE RIGIDIIY IN RATS
- QT PRODACT : Evaluation of the Potential of Compounds to Cause QT Interval Prolongation by Action Potential Assays Using Guinea-Pig Papillary Muscles
- QT PRODACT : A Multi-site Study of In Vitro Action Potential Assays on 21 Compounds in Isolated Guinea-Pig Papillary Muscles
- Structure-Activity Relationships of Phenylethylamine Analogs in Their Serotonergic Depressant Effects on the Spinal Monosynaptic Reflex in Rats
- Enhancement of Spinal Monosynaptic Reflexes with Phenylethylamine and Related Drugs through Descending Noradrenergic Neurons
- A facile synthesis of Tyrian purple based on a biosynthetic pathway
- Roles of γ-Aminobutyric Acid_B (GABA_B) and γ-Hydroxybutyric Acid Receptors in Hippocampal Long-Term Potentiation and Pathogenesis of Absence Seizures
- Pharmacological profiles of generalized absence seizures in lethargic, stargazer and γ-hydroxybutyrate-treated model mice
- PHARMACOLOGICAL EVALUATION OF GARENOXACIN, A NOVEL DES-F(6)-QUINOLONE ANTIMICROBIAL AGENT : EFFECTS ON THE CENTRAL NERVOUS SYSTEM
- EFFECT OF NMDA RECEPTOR ANTAGONISTS ON PROTEIN KINASE ACTIVATED BY CHRONIC MORPHINE TREATMENT
- INHIBITORY EFFECT OF THE NMDA RECEPTOR ANTAGONIST, DIZOCILPINE (MK-801), ON THE DEVELOPMENT OF MORPHINE DEPENDENCE
- SPINAL REFLEXES IN CHINOFORM-ADMINISTERED RATS
- SPINAL REFLEXES IN RATS SUFFERED FROM MOTOR INCOORDINATION BY CHINOFORM
- Effects of quinolone antibacterial agents and related compounds on GABA_A receptor chloride ion channels.
- DETERIORATION OF SPINAL REFLEX IN QUAILS ORALLY INGESTING CLIOQUINOL
- EFFECTS OF METABOLIC INHIBITORS AND OUABAIN ON STATIC AFFERENT DISCHARGES FROM THE ISOLATED FROG MUSCLE SPINDLE
- EFFECTS OF CENTRALLY ACTING MUSCLE RELAXANTS ON THE ANEMIC DECEREBRATE RIGIDITY IN RATS
- EFFECT OF BACLOFEN ON THE γ-MOTOR ACTIVITY IN THE RAT
- MODE OF ACTION OF L-DOPA ON γ-MOTOR SYSTEM IN THE RAT
- ANTICONVULSANT ACTION OF DIAZEPAM IN MICE PRETREATED WITH CAFFEINE
- IMPAIRMENT OF MOTOR SYSTEM IN QUAILS GIVEN CHINOFORM
- POSTNATAL DEVELOPMENT OF THE BENZODIAZEPINE AND GABA RECEPTORS IN THE RAT SPINAL CORD
- POSTNATAL DEVELOPMENT OF THE GABA SYSTEM IN THE RAT SPINAL CORD
- EFFECTS OF ANTICHOLINERGICS ON THE AFFERENT DISCHARGES FROM THE MUSCLE SPINDLE OF THE BULLFROG IN VITRO
- EFFECTS OF ZOPICLONE AND BENZODIAZEPINES ON SPINAL REFLEXES, ANEMIC DECEREBRATE RIGIDITY AND BENZODIAZEPINE BINDING
- Muscle relaxation mediated by central alpha_2-agonistic action in decerebrate rigidity in rats
- PHARMACOLOGICAL EVALUATION OF MUSCLE RELAXANTS
- DECREASE IN EFFECTS OF MUSCIMOL ON THE DORSAL ROOT AFTER REPEATED ADMINISTRATION OF DIAZEPAM IN RATS
- MECHANISMS OF DEPRESSANT ACTION OF MUSCLE RELAXANTS ON SPINAL REFLEXES : PARTICIPATION OF MEMBRANE STABILIZING ACTION
- EXCITATION BY LYONIOL-A OF VAGAL AFFERENT NERVES AND THE REFLEX AUTONOMIC AND SOMATIC ACTIONS IN RATS
- EFFECTS OF EXCITATORY TRANSMITTER CANDIDATES ON FROG SPINAL MOTOR FUNCTION
- ALTERATIONS IN SPONTANEOUS ACTIVITY OF THE ISOLATED FROG SPINAL CORD IN CALCIUM-FREE ENVIRONMENT
- ALTERATION OF EXTRACELLULAR K+-ACTIVITY INDUCED BY AMINO ACIDS IN THE FROG SPINAL CORD
- RIGIDITY IN RATS DUE TO ANEMIC DECEREBRATION AND THE EFFECT OF CHLORPROMAZINE
- EFFECT OF LYONIOL-A ON DECEREBRATE RIGIDITY AND ELECTROENCEPHALOGRAM IN RATS
- SPONTANEOUS ELECTRICAL ACTIVITY OF THE BULLFROG SPINAL CORD AND SUSCEPTIBILITY TO SOME CENTRALLY ACTING DRUGS AND AMINO ACIDS
- Effects of propentofylline on disorder of learning and memory in rodents.
- Amphetamine-Antagonistic Property of 4-Phenyltetrahydroisoquinoline: Effect on Noradrenaline Release in Spinal Cord Slices.
- 2-Phenylethylamine and methamphetamine enhance the spinal monosynaptic reflex by releasing noradrenaline from the terminals of descending fibers.
- Effects of pentobarbital on (3H)diazepam binding in the cerebral cortex, cerebellum and spinal cord of developing rats.
- Effect of the Centrally Acting Muscle Relaxant Tizanidine on Spinal Reflexes: Involvement of Descending Noradrenergic Systems.
- Spinal .ALPHA.1- and .ALPHA.2-adrenoceptors mediate facilitation and inhibition of spinal motor transmission, respectively.