Effect of the Centrally Acting Muscle Relaxant Tizanidine on Spinal Reflexes: Involvement of Descending Noradrenergic Systems.
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概要
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Experiments were performed on intact and spinalized rats anesthetized with urethane and α-chloralose. In intact rats, administration of tizanidine (0.1 mg/kg, i.v.) decreased the mono- (MSR) and polysynaptic reflex potentials (PSR). Blood pressure was initially elevated and then lowered by tizanidine. Although pretreatments with hexamethonium and phentolamine prevented the tizanidine-induced decrease in blood pressure, the depressant effects of tizanidine on the reflexes remained. The α<SUB>2</SUB>-antagonist idazoxan inhibited the tizanidine-induced decrease in spinal reflexes, suggesting that central α<SUB>2</SUB>-adrenoceptors are involved in the depression of the reflexes. In spinalized rats, tizanidine transiently increased the MSR and gradually decreased the PSR. Blood pressure was elevated transiently by tizanidine. Although the hypertensive effect of tizanidine was inhibited by phentolamine, the effect of tizanidine on the PSR did not change. Prazosin blocked the stimulatory effect of tizanidine on the MSR and caused a rapid decrease of the PSR, suggesting that spinal α<SUB>1</SUB>-adrenoceptors are involved in the enhancement of the reflexes. These results suggest that the depressant effects of tizanidine on spinal reflexes are due to the supraspinal and spinal effects of the drug, and not to changes in blood pressure.
- 公益社団法人 日本薬理学会の論文
著者
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Ono Hideki
Department Of Cardiology Ninon University Surugadai Hospital
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FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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FUKUSHIMA Chiharu
Department of Mechanical Systems Engineering, Hiroshima Institute of Technology
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Ono Hideki
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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