MECHANISMS OF DEPRESSANT ACTION OF MUSCLE RELAXANTS ON SPINAL REFLEXES : PARTICIPATION OF MEMBRANE STABILIZING ACTION
スポンサーリンク
概要
- 論文の詳細を見る
The participation of local anesthetic action in spinal reflex inhibition produced by mephenesin-type muscle relaxants was examined by comparing the local anesthetic effects (in vitro), the depressant effects on muscle afferent discharges (in situ) and the depressant effects on spinal reflexes (in situ) of the drugs in rats. At doses producing depression of spinal reflexes, mephenesin, tolperisone (mephenesin-type) and lidocaine (local anesthetic) reduced the frequency of afferent discharges from the muscle. The order of reducing afferent discharges by these drugs corresponded to that of their conduction blocking activities in the isolated sciatic nerve of rats. These results suggest the participation of a membrane stabilizing action in spinal reflex inhibition produced by mephenesin-type muscle relaxants. Baclofen (non-mephenesin-type) did not show any local anesthetic action.
- 公益社団法人日本薬学会の論文
著者
-
FUKUDA Hideomi
Department of Pharmacology, College of Pharmacy, Nihon University
-
Fukuda H
Department Of Pharmacology College Of Pharmacy Nihon University
-
Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
-
Kudo Yoshihisa
Laboratory Of Cellular Neurobiology School Of Life Science Tokyo University Of Pharmacy And Life Sci
-
Kudo Yoshihisa
Laboratory Of Neuropharmacology Mitsubishi-kasei Institute Of Life Sciences
-
Ono Hideki
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
-
Ono Hideki
Department Of Cardiology Ninon University Surugadai Hospital
-
FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
関連論文
- Comparative study of survival signal withdrawal- and 4-hydroxynonenal-induced cell death in cerebellar granule cells
- OE-016 Prognostic Value of Left Ventricular Hypertrophy on ECG in Single Photon Emission Computed Tomography(Nuclear Cardiology 1 (I) : OE3)(Oral Presentation (English))
- A Double-blind Study of Locally Applied 2% Aspirin Ointment in the Treatment for Painful Oral Mucous Ulcers
- EFFECTS OF VALPROIC ACID ON SPINAL REFLEXES AND [^3H]MUSCIMOL AND [^3H]DIAZEPAM BINDING IN BRAIN MEMBRANES IN RATS
- IMPAIRMENT OF VISUAL SYSTEM OF BEAGLES ORALLY INGESTING CLIOQUINOL
- DETERIORATION OF SPINAL REFLEX IN BEAGLES ORALLY INGESTING CLIOQUINOL
- CENTRALLY SPECIFIC AND GABA-INSENSITIVE INHIBITION OF BENZODIAZEPINE BINDING BY PROSTAGLANDINS (A_1,A_2 AND B_2)
- γ-AMINOBUTYRIC ACID AND BENZODIAZEPINE RECEPTOR INTERACTION
- EFFECTS OF BARBITURATES ON THE DECEREBRATE RIGIDIIY IN RATS
- QT PRODACT : Evaluation of the Potential of Compounds to Cause QT Interval Prolongation by Action Potential Assays Using Guinea-Pig Papillary Muscles
- QT PRODACT : A Multi-site Study of In Vitro Action Potential Assays on 21 Compounds in Isolated Guinea-Pig Papillary Muscles
- A mouse with a point mutation in plasma membrane Ca^-ATPase isoform 2 gene showed the reduced Ca^ influx in cerebellar neurons
- Structure-Activity Relationships of Phenylethylamine Analogs in Their Serotonergic Depressant Effects on the Spinal Monosynaptic Reflex in Rats
- Enhancement of Spinal Monosynaptic Reflexes with Phenylethylamine and Related Drugs through Descending Noradrenergic Neurons
- Prognostic value of normal myocardial perfusion SPECT in patients with relatively short exercise duration
- Measurement of Nitrogen Dissolution Rate into Molten Alloys by Isotope Exchange Technique (高温質量分析特集号)
- Pancreatic Injury Successfully Treated with Endoscopic Stenting for Major Pancreatic Duct Disruption
- Roles of γ-Aminobutyric Acid_B (GABA_B) and γ-Hydroxybutyric Acid Receptors in Hippocampal Long-Term Potentiation and Pathogenesis of Absence Seizures
- Pharmacological profiles of generalized absence seizures in lethargic, stargazer and γ-hydroxybutyrate-treated model mice
- PHARMACOLOGICAL EVALUATION OF GARENOXACIN, A NOVEL DES-F(6)-QUINOLONE ANTIMICROBIAL AGENT : EFFECTS ON THE CENTRAL NERVOUS SYSTEM
- EFFECT OF NMDA RECEPTOR ANTAGONISTS ON PROTEIN KINASE ACTIVATED BY CHRONIC MORPHINE TREATMENT
- INHIBITORY EFFECT OF THE NMDA RECEPTOR ANTAGONIST, DIZOCILPINE (MK-801), ON THE DEVELOPMENT OF MORPHINE DEPENDENCE
- SPINAL REFLEXES IN CHINOFORM-ADMINISTERED RATS
- SPINAL REFLEXES IN RATS SUFFERED FROM MOTOR INCOORDINATION BY CHINOFORM
- Transient Increase in Intracellular Calcium in Streptomyces alboniger Produced by Pamamycin-607, an Aerial Mycelium-inducing Substance
- Influence of Neodymium on the Deoxidation and Desulfurization Equilibria of Liquid Iron in the Fe-Nd-O-S(-Al) System at 1873K
- Adult Onset of Inflammatory Linear Verrucous Epidermal Nevus
- Expression of Group I Metabotropic Glutamate Receptors in Rat Hippocampal Cells in Culture and Their Characterization by Intracellular Calcium Ion Dynamics
- Effects of quinolone antibacterial agents and related compounds on GABA_A receptor chloride ion channels.
- DETERIORATION OF SPINAL REFLEX IN QUAILS ORALLY INGESTING CLIOQUINOL
- EFFECTS OF METABOLIC INHIBITORS AND OUABAIN ON STATIC AFFERENT DISCHARGES FROM THE ISOLATED FROG MUSCLE SPINDLE
- An Extended INDO-CI Theory of the General Relation between Bond Length and Bond Order
- Theory of the Relation between Bond Length and Bond Order by an Extended INDO Method
- NMDA receptor-mediated depolarizing after-potentials in the basal dendrites of CA1 pyramidal neurons
- Macroscale and microscale analyses of nitrification and denitrification in biofilms attached on membrane aerated biofilm reactors
- Effect of oxygen concentration on nitrification and denitrification in single activated sludge flocs
- EFFECTS OF CENTRALLY ACTING MUSCLE RELAXANTS ON THE ANEMIC DECEREBRATE RIGIDITY IN RATS
- EFFECT OF BACLOFEN ON THE γ-MOTOR ACTIVITY IN THE RAT
- MODE OF ACTION OF L-DOPA ON γ-MOTOR SYSTEM IN THE RAT
- Inhibitory Effect of the Phosphoinositide 3-Kinase Inhibitor LY294002 on Muscarinic Acetylcholine Receptor-Induced Calcium Entry in PC12h
- Studies on the Latex Agglutination Inhibition Method for Assay of Plasma Theophylline Concentration
- ANTICONVULSANT ACTION OF DIAZEPAM IN MICE PRETREATED WITH CAFFEINE
- POSTNATAL DEVELOPMENT OF THE BENZODIAZEPINE AND GABA RECEPTORS IN THE RAT SPINAL CORD
- POSTNATAL DEVELOPMENT OF THE GABA SYSTEM IN THE RAT SPINAL CORD
- A Novel Method to Quantify Calcium Response Pattern and Oscillation Using Fura2 and Acridine Orange
- EFFECTS OF ANTICHOLINERGICS ON THE AFFERENT DISCHARGES FROM THE MUSCLE SPINDLE OF THE BULLFROG IN VITRO
- EFFECTS OF ZOPICLONE AND BENZODIAZEPINES ON SPINAL REFLEXES, ANEMIC DECEREBRATE RIGIDITY AND BENZODIAZEPINE BINDING
- Muscle relaxation mediated by central alpha_2-agonistic action in decerebrate rigidity in rats
- Effects of Mannitol on Ischemia-Induced Degeneration in Rat Hippocampus
- Cyclic AMP Detection by Electrode Modified with 17mer Oligopeptide
- PHARMACOLOGICAL EVALUATION OF MUSCLE RELAXANTS
- DECREASE IN EFFECTS OF MUSCIMOL ON THE DORSAL ROOT AFTER REPEATED ADMINISTRATION OF DIAZEPAM IN RATS
- MECHANISMS OF DEPRESSANT ACTION OF MUSCLE RELAXANTS ON SPINAL REFLEXES : PARTICIPATION OF MEMBRANE STABILIZING ACTION
- EXCITATION BY LYONIOL-A OF VAGAL AFFERENT NERVES AND THE REFLEX AUTONOMIC AND SOMATIC ACTIONS IN RATS
- EFFECTS OF EXCITATORY TRANSMITTER CANDIDATES ON FROG SPINAL MOTOR FUNCTION
- ALTERATIONS IN SPONTANEOUS ACTIVITY OF THE ISOLATED FROG SPINAL CORD IN CALCIUM-FREE ENVIRONMENT
- ALTERATION OF EXTRACELLULAR K+-ACTIVITY INDUCED BY AMINO ACIDS IN THE FROG SPINAL CORD
- RIGIDITY IN RATS DUE TO ANEMIC DECEREBRATION AND THE EFFECT OF CHLORPROMAZINE
- EFFECT OF LYONIOL-A ON DECEREBRATE RIGIDITY AND ELECTROENCEPHALOGRAM IN RATS
- SPONTANEOUS ELECTRICAL ACTIVITY OF THE BULLFROG SPINAL CORD AND SUSCEPTIBILITY TO SOME CENTRALLY ACTING DRUGS AND AMINO ACIDS
- ANTAGONISTIC EFFECT OF 4-PHENYLTETRAHYDROISOQUINOLINE AGAINST AMPHETAMINES
- Amphetamine-Antagonistic Property of 4-Phenyltetrahydroisoquinoline: Effect on Noradrenaline Release in Spinal Cord Slices.
- 2-Phenylethylamine and methamphetamine enhance the spinal monosynaptic reflex by releasing noradrenaline from the terminals of descending fibers.
- Effects of pentobarbital on (3H)diazepam binding in the cerebral cortex, cerebellum and spinal cord of developing rats.
- Effect of the Centrally Acting Muscle Relaxant Tizanidine on Spinal Reflexes: Involvement of Descending Noradrenergic Systems.
- Spinal .ALPHA.1- and .ALPHA.2-adrenoceptors mediate facilitation and inhibition of spinal motor transmission, respectively.